Defining the condensate landscape of fusion oncoproteins
Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates, the generality of this phenomenon is unknown. W...
Uloženo v:
| Vydáno v: | Nature communications Ročník 14; číslo 1; s. 6008 - 25 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
28.09.2023
Nature Publishing Group Nature Portfolio |
| Témata: | |
| ISSN: | 2041-1723, 2041-1723 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates, the generality of this phenomenon is unknown. We explored this question by testing 166 FOs in HeLa cells and found that 58% formed condensates. The condensate-forming FOs displayed physicochemical features distinct from those of condensate-negative FOs and segregated into distinct feature-based groups that aligned with their sub-cellular localization and biological function. Using Machine Learning, we developed a predictor of FO condensation behavior, and discovered that 67% of ~3000 additional FOs likely form condensates, with 35% of those predicted to function by altering gene expression. 47% of the predicted condensate-negative FOs were associated with cell signaling functions, suggesting a functional dichotomy between condensate-positive and -negative FOs. Our Datasets and reagents are rich resources to interrogate FO condensation in the future.
Many fusion oncoproteins (FOs) form condensates, some form in the nucleus and regulate gene expression while others form in the cytoplasm and promote cell signaling. In this work, the authors report the analysis of physicochemical features to enable prediction of FO condensation behavior. |
|---|---|
| AbstractList | Abstract Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates, the generality of this phenomenon is unknown. We explored this question by testing 166 FOs in HeLa cells and found that 58% formed condensates. The condensate-forming FOs displayed physicochemical features distinct from those of condensate-negative FOs and segregated into distinct feature-based groups that aligned with their sub-cellular localization and biological function. Using Machine Learning, we developed a predictor of FO condensation behavior, and discovered that 67% of ~3000 additional FOs likely form condensates, with 35% of those predicted to function by altering gene expression. 47% of the predicted condensate-negative FOs were associated with cell signaling functions, suggesting a functional dichotomy between condensate-positive and -negative FOs. Our Datasets and reagents are rich resources to interrogate FO condensation in the future. Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates, the generality of this phenomenon is unknown. We explored this question by testing 166 FOs in HeLa cells and found that 58% formed condensates. The condensate-forming FOs displayed physicochemical features distinct from those of condensate-negative FOs and segregated into distinct feature-based groups that aligned with their sub-cellular localization and biological function. Using Machine Learning, we developed a predictor of FO condensation behavior, and discovered that 67% of ~3000 additional FOs likely form condensates, with 35% of those predicted to function by altering gene expression. 47% of the predicted condensate-negative FOs were associated with cell signaling functions, suggesting a functional dichotomy between condensate-positive and -negative FOs. Our Datasets and reagents are rich resources to interrogate FO condensation in the future. Many fusion oncoproteins (FOs) form condensates, some form in the nucleus and regulate gene expression while others form in the cytoplasm and promote cell signaling. In this work, the authors report the analysis of physicochemical features to enable prediction of FO condensation behavior. Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates, the generality of this phenomenon is unknown. We explored this question by testing 166 FOs in HeLa cells and found that 58% formed condensates. The condensate-forming FOs displayed physicochemical features distinct from those of condensate-negative FOs and segregated into distinct feature-based groups that aligned with their sub-cellular localization and biological function. Using Machine Learning, we developed a predictor of FO condensation behavior, and discovered that 67% of ~3000 additional FOs likely form condensates, with 35% of those predicted to function by altering gene expression. 47% of the predicted condensate-negative FOs were associated with cell signaling functions, suggesting a functional dichotomy between condensate-positive and -negative FOs. Our Datasets and reagents are rich resources to interrogate FO condensation in the future. Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates, the generality of this phenomenon is unknown. We explored this question by testing 166 FOs in HeLa cells and found that 58% formed condensates. The condensate-forming FOs displayed physicochemical features distinct from those of condensate-negative FOs and segregated into distinct feature-based groups that aligned with their sub-cellular localization and biological function. Using Machine Learning, we developed a predictor of FO condensation behavior, and discovered that 67% of ~3000 additional FOs likely form condensates, with 35% of those predicted to function by altering gene expression. 47% of the predicted condensate-negative FOs were associated with cell signaling functions, suggesting a functional dichotomy between condensate-positive and -negative FOs. Our Datasets and reagents are rich resources to interrogate FO condensation in the future. Many fusion oncoproteins (FOs) form condensates, some form in the nucleus and regulate gene expression while others form in the cytoplasm and promote cell signaling. In this work, the authors report the analysis of physicochemical features to enable prediction of FO condensation behavior. Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates, the generality of this phenomenon is unknown. We explored this question by testing 166 FOs in HeLa cells and found that 58% formed condensates. The condensate-forming FOs displayed physicochemical features distinct from those of condensate-negative FOs and segregated into distinct feature-based groups that aligned with their sub-cellular localization and biological function. Using Machine Learning, we developed a predictor of FO condensation behavior, and discovered that 67% of ~3000 additional FOs likely form condensates, with 35% of those predicted to function by altering gene expression. 47% of the predicted condensate-negative FOs were associated with cell signaling functions, suggesting a functional dichotomy between condensate-positive and -negative FOs. Our Datasets and reagents are rich resources to interrogate FO condensation in the future.Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates, the generality of this phenomenon is unknown. We explored this question by testing 166 FOs in HeLa cells and found that 58% formed condensates. The condensate-forming FOs displayed physicochemical features distinct from those of condensate-negative FOs and segregated into distinct feature-based groups that aligned with their sub-cellular localization and biological function. Using Machine Learning, we developed a predictor of FO condensation behavior, and discovered that 67% of ~3000 additional FOs likely form condensates, with 35% of those predicted to function by altering gene expression. 47% of the predicted condensate-negative FOs were associated with cell signaling functions, suggesting a functional dichotomy between condensate-positive and -negative FOs. Our Datasets and reagents are rich resources to interrogate FO condensation in the future. |
| ArticleNumber | 6008 |
| Author | Jarosz, Daniel F. Babu, M. Madan Edmonson, Michael N. White, Michael R. Park, Cheon-Gil Rice, Stephen V. Li, Yongsheng Baggett, David W. Bollinger, John Zhang, Jinghui Pioso, Brittany J. Iacobucci, Ilaria Mitrea, Diana M. Somjee, Ramiz Hosseini, Seyed Mohammad Hadi Mullighan, Charles G. McGrail, Daniel J. Sahni, Nidhi Shirnekhi, Hazheen K. Zhou, Xin Lang, Benjamin Gao, Qingsong Tripathi, Swarnendu Yi, S. Stephen Kriwacki, Richard W. Gorman, Scott D. Chandra, Bappaditya |
| Author_xml | – sequence: 1 givenname: Swarnendu surname: Tripathi fullname: Tripathi, Swarnendu organization: Department of Structural Biology, St. Jude Children’s Research Hospital – sequence: 2 givenname: Hazheen K. orcidid: 0000-0002-6685-2586 surname: Shirnekhi fullname: Shirnekhi, Hazheen K. organization: Department of Structural Biology, St. Jude Children’s Research Hospital – sequence: 3 givenname: Scott D. orcidid: 0000-0002-0601-6383 surname: Gorman fullname: Gorman, Scott D. organization: Department of Structural Biology, St. Jude Children’s Research Hospital, Arrakis Therapeutics – sequence: 4 givenname: Bappaditya surname: Chandra fullname: Chandra, Bappaditya organization: Department of Structural Biology, St. Jude Children’s Research Hospital – sequence: 5 givenname: David W. surname: Baggett fullname: Baggett, David W. organization: Department of Structural Biology, St. Jude Children’s Research Hospital – sequence: 6 givenname: Cheon-Gil surname: Park fullname: Park, Cheon-Gil organization: Department of Structural Biology, St. Jude Children’s Research Hospital – sequence: 7 givenname: Ramiz orcidid: 0000-0003-1721-1616 surname: Somjee fullname: Somjee, Ramiz organization: Department of Structural Biology, St. Jude Children’s Research Hospital, Rhodes College, Washington University School of Medicine – sequence: 8 givenname: Benjamin orcidid: 0000-0001-6358-8380 surname: Lang fullname: Lang, Benjamin organization: Department of Structural Biology, St. Jude Children’s Research Hospital, Center of Excellence for Data-Driven Discovery, Department of Structural Biology, St. Jude Children’s Research Hospital – sequence: 9 givenname: Seyed Mohammad Hadi surname: Hosseini fullname: Hosseini, Seyed Mohammad Hadi organization: Department of Structural Biology, St. Jude Children’s Research Hospital, Center of Excellence for Data-Driven Discovery, Department of Structural Biology, St. Jude Children’s Research Hospital – sequence: 10 givenname: Brittany J. orcidid: 0000-0002-0123-8905 surname: Pioso fullname: Pioso, Brittany J. organization: Department of Structural Biology, St. Jude Children’s Research Hospital – sequence: 11 givenname: Yongsheng orcidid: 0000-0001-6047-9592 surname: Li fullname: Li, Yongsheng organization: Livestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin – sequence: 12 givenname: Ilaria orcidid: 0000-0003-2008-1365 surname: Iacobucci fullname: Iacobucci, Ilaria organization: Department of Pathology, St. Jude Children’s Research Hospital – sequence: 13 givenname: Qingsong surname: Gao fullname: Gao, Qingsong organization: Department of Pathology, St. Jude Children’s Research Hospital – sequence: 14 givenname: Michael N. orcidid: 0000-0003-0339-700X surname: Edmonson fullname: Edmonson, Michael N. organization: Department of Computational Biology, St. Jude Children’s Research Hospital – sequence: 15 givenname: Stephen V. surname: Rice fullname: Rice, Stephen V. organization: Department of Computational Biology, St. Jude Children’s Research Hospital – sequence: 16 givenname: Xin surname: Zhou fullname: Zhou, Xin organization: Department of Computational Biology, St. Jude Children’s Research Hospital – sequence: 17 givenname: John surname: Bollinger fullname: Bollinger, John organization: Department of Structural Biology, St. Jude Children’s Research Hospital – sequence: 18 givenname: Diana M. surname: Mitrea fullname: Mitrea, Diana M. organization: Department of Structural Biology, St. Jude Children’s Research Hospital, Dewpoint Therapeutics – sequence: 19 givenname: Michael R. surname: White fullname: White, Michael R. organization: Department of Structural Biology, St. Jude Children’s Research Hospital, IDEXX Laboratories, Inc – sequence: 20 givenname: Daniel J. orcidid: 0000-0002-6669-6069 surname: McGrail fullname: McGrail, Daniel J. organization: Center for Immunotherapy and Precision Immuno-Oncology, Cleveland Clinic, Lerner Research Institute, Cleveland Clinic – sequence: 21 givenname: Daniel F. orcidid: 0000-0003-3497-5888 surname: Jarosz fullname: Jarosz, Daniel F. organization: Department of Chemical and Systems Biology, Stanford University School of Medicine, Department of Developmental Biology, Stanford University School of Medicine – sequence: 22 givenname: S. Stephen orcidid: 0000-0003-0047-8103 surname: Yi fullname: Yi, S. Stephen organization: Livestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Department of Biomedical Engineering, and Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin – sequence: 23 givenname: M. Madan orcidid: 0000-0003-0556-6196 surname: Babu fullname: Babu, M. Madan organization: Department of Structural Biology, St. Jude Children’s Research Hospital, Center of Excellence for Data-Driven Discovery, Department of Structural Biology, St. Jude Children’s Research Hospital – sequence: 24 givenname: Charles G. orcidid: 0000-0002-1871-1850 surname: Mullighan fullname: Mullighan, Charles G. organization: Department of Pathology, St. Jude Children’s Research Hospital – sequence: 25 givenname: Jinghui orcidid: 0000-0003-3350-9682 surname: Zhang fullname: Zhang, Jinghui organization: Department of Computational Biology, St. Jude Children’s Research Hospital – sequence: 26 givenname: Nidhi orcidid: 0000-0002-9155-5882 surname: Sahni fullname: Sahni, Nidhi organization: Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Program in Quantitative and Computational Biosciences, Baylor College of Medicine – sequence: 27 givenname: Richard W. orcidid: 0000-0002-9798-6018 surname: Kriwacki fullname: Kriwacki, Richard W. email: richard.kriwacki@stjude.org organization: Department of Structural Biology, St. Jude Children’s Research Hospital, Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37770423$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Uk1vFSEUJabG1to_4MJM4sbNKJ8DrIypX02auNE14cHllZd58ATGxH8vdmptuygbCJxz7uHe8xwdpZwAoZcEvyWYqXeVEz7JEVM2cjIJMdIn6IRiTkYiKTu6cz5GZ7XucF9ME8X5M3TMpJSYU3aC1EcIMcW0HdoVDC4nD6naBsNsk6_OHmDIYQhLjTkNObl8KLlBTPUFehrsXOHsZj9FPz5_-n7-dbz89uXi_MPl6AQnbbTOgdLWOxrYhgahNz5wTTGlBNyEqVdeBa6EI0DBM-mk99aB5NoRKZxlp-hi1fXZ7syhxL0tv0220Vxf5LI1trToZjAqMOG6xhSk5cqSXk8zIZW1mJINTF3r_ap1WDZ78A5SK3a-J3r_JcUrs82_DMGCaUZFV3hzo1DyzwVqM_tYHcy9W5CXaqiSWGsiJtWhrx9Ad3kpqfeqoyatMJ0m0lGv7lq69fJvQh1AV4ArudYC4RZCsPmbBLMmwfQkmOskGNpJ6gHJxWZbn2H_Vpwfp7KVWnudtIXy3_YjrD8uNceO |
| CitedBy_id | crossref_primary_10_1038_s43018_024_00777_2 crossref_primary_10_1016_j_jmb_2025_169449 crossref_primary_10_1002_ijc_35424 crossref_primary_10_1016_j_jmb_2024_168835 crossref_primary_10_1016_j_gde_2024_102203 crossref_primary_10_1093_procel_pwad057 crossref_primary_10_1016_j_gde_2024_102285 crossref_primary_10_1016_j_cell_2025_04_002 crossref_primary_10_1038_s41467_024_53451_7 crossref_primary_10_1007_s00441_025_03974_2 crossref_primary_10_1016_j_tibs_2023_10_002 crossref_primary_10_1038_s41586_025_09141_5 crossref_primary_10_1126_sciadv_ads7876 crossref_primary_10_1016_j_bbcan_2024_189245 crossref_primary_10_1038_s41592_025_02726_y crossref_primary_10_3390_cells14130947 crossref_primary_10_1038_s41556_025_01745_3 crossref_primary_10_1038_s41557_024_01655_1 crossref_primary_10_1038_s41580_024_00789_x crossref_primary_10_1038_s41576_025_00816_3 crossref_primary_10_3390_cancers16071351 crossref_primary_10_1080_0035919X_2025_2519206 crossref_primary_10_1016_j_molcel_2025_03_004 crossref_primary_10_1073_pnas_2417920122 crossref_primary_10_26508_lsa_202402602 crossref_primary_10_3390_cancers16091622 crossref_primary_10_1038_s41467_024_47055_4 crossref_primary_10_1152_physiol_00013_2024 crossref_primary_10_3390_ijms26115156 crossref_primary_10_1038_s41576_024_00780_4 crossref_primary_10_1158_0008_5472_CAN_23_2769 crossref_primary_10_3389_fimmu_2025_1604015 crossref_primary_10_1158_2159_8290_CD_24_0417 crossref_primary_10_1038_s41467_025_58872_6 crossref_primary_10_1158_2159_8290_CD_23_1551 |
| Cites_doi | 10.1093/nar/28.1.235 10.1182/blood.2021012806 10.2174/092986608785849164 10.1080/01621459.1963.10500845 10.1038/s41592-022-01507-1 10.1093/bioinformatics/btv153 10.1093/nar/gkaa977 10.1021/acs.jpclett.0c00288 10.1016/S0022-5193(05)80054-2 10.1093/bioinformatics/btu310 10.1186/s13059-020-02043-x 10.1146/annurev-cancerbio-061421-122050 10.1186/1471-2105-10-202 10.1093/database/baw027 10.1073/pnas.1119366109 10.1021/jacs.6b10272 10.1073/pnas.1304749110 10.1126/sciadv.abb5924 10.1093/nar/gkaa980 10.1016/j.cell.2017.07.036 10.1063/1.4929391 10.1038/nrm.2017.7 10.1038/s41573-021-00371-6 10.1093/nar/gkw282 10.1016/0022-2836(82)90515-0 10.1093/bioinformatics/btu031 10.1016/j.molcel.2022.06.024 10.1158/2643-3230.BCD-20-0229 10.1093/nar/gkz991 10.1146/annurev-cellbio-100913-013325 10.1073/pnas.0706251104 10.1038/s41588-018-0315-5 10.1038/s41421-021-00270-5 10.1101/gr.1239303 10.1038/ncomms5846 10.1093/nar/gkz778 10.1016/j.ccell.2016.10.019 10.1016/j.celrep.2018.03.050 10.1016/j.bpj.2016.11.3200 10.1016/j.celrep.2016.05.076 10.1101/2022.12.19.521099 10.1016/S0076-6879(96)66035-2 10.1126/science.aar2555 10.1002/pro.4127 10.1093/nar/gkz1027 10.1186/s13046-022-02248-x 10.1016/j.molcel.2016.07.008 10.1038/s41418-022-00955-8 10.1093/nar/gkv1189 10.1038/nrc.2017.36 10.1247/csf.19033 10.1038/ng.2287 10.1016/j.ymeth.2016.09.016 10.1093/nar/25.17.3389 10.5808/GI.2019.17.3.e26 10.7554/eLife.31486 10.1016/j.str.2016.07.007 10.1158/2159-8290.CD-21-0674 10.1038/nrc1567 10.1038/s41598-018-28948-z 10.1038/s41588-022-01159-z 10.1038/s41568-019-0132-x 10.1016/j.cell.2022.12.013 10.1110/ps.4210102 10.1186/s12964-015-0125-7 10.1073/pnas.0911107107 10.1016/j.celrep.2016.06.088 10.1016/j.molcel.2015.01.013 10.1093/nar/gkx965 10.1038/s41586-021-03662-5 10.1242/jcs.258578 10.1126/science.aar3958 10.1126/science.aaz4427 10.1093/nar/gkz847 10.1158/2159-8290.CD-20-1230 10.1016/j.cell.2021.03.031 10.1158/2159-8290.CD-20-1631 10.1093/nar/gkx1018 10.1073/pnas.2007670117 10.1016/j.cell.2018.06.006 10.1016/j.cell.2018.10.042 10.1093/nar/gkac240 10.1093/nar/gkaa1100 10.1021/jacs.7b01380 10.1021/acs.jpcb.0c11479 10.1093/nar/gky384 10.1038/s41594-020-00550-w 10.1038/srep15686 10.1016/j.bpj.2019.08.030 10.1016/j.ccell.2019.11.001 10.1093/bioinformatics/btl117 10.1073/pnas.2019053118 10.1093/bib/bbaa408 10.1038/nmeth.2019 10.15252/embr.202153693 10.1261/rna.078827.121 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2023 2023. Springer Nature Limited. The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Springer Nature Limited 2023 |
| Copyright_xml | – notice: The Author(s) 2023 – notice: 2023. Springer Nature Limited. – notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Springer Nature Limited 2023 |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 5PM DOA |
| DOI | 10.1038/s41467-023-41655-2 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic ProQuest Publicly Available Content ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE MEDLINE - Academic Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2041-1723 |
| EndPage | 25 |
| ExternalDocumentID | oai_doaj_org_article_8f35cd376f7a48a1b2f93578aa021be6 PMC10539325 37770423 10_1038_s41467_023_41655_2 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) – fundername: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) grantid: R35 GM133658; P30 CA021765; R35 CA197695; R01 CA246125; U54 CA243124; R01 CA216391; T32 CA236748; P30 CA021765; K99 CA240689 funderid: https://doi.org/10.13039/100000054 – fundername: Susan G. Komen (Susan G. Komen Breast Cancer Foundation) grantid: CCR19609287; PDF17483544 funderid: https://doi.org/10.13039/100009634 – fundername: Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) grantid: RR160021; RP220292 funderid: https://doi.org/10.13039/100004917 – fundername: NIGMS NIH HHS grantid: R35 GM137836 – fundername: NIGMS NIH HHS grantid: R35 GM133658 – fundername: NCI NIH HHS grantid: R35 CA197695 – fundername: NCI NIH HHS grantid: R01 CA216391 – fundername: NCI NIH HHS grantid: U54 CA243124 – fundername: NCI NIH HHS grantid: P30 CA021765 – fundername: NIGMS NIH HHS grantid: F32 GM143847 – fundername: NCI NIH HHS grantid: K99 CA240689 – fundername: NCI NIH HHS grantid: T32 CA236748 – fundername: NCI NIH HHS grantid: R01 CA246125 – fundername: ; – fundername: ; grantid: CCR19609287; PDF17483544 – fundername: ; grantid: R35 GM133658; P30 CA021765; R35 CA197695; R01 CA246125; U54 CA243124; R01 CA216391; T32 CA236748; P30 CA021765; K99 CA240689 – fundername: ; grantid: RR160021; RP220292 |
| GroupedDBID | --- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LGEZI LK8 LOTEE M1P M48 M7P M~E NADUK NAO NXXTH O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX AFFHD CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 SOI 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c541t-acce89adc2f3b2f59bdf4920221ec602d8d8f485c1e2ed37c7ddace749c175ca3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 38 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001080410400020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2041-1723 |
| IngestDate | Tue Oct 14 18:57:51 EDT 2025 Tue Nov 04 02:06:22 EST 2025 Fri Sep 05 12:30:26 EDT 2025 Tue Oct 07 07:16:13 EDT 2025 Mon Jul 21 05:57:15 EDT 2025 Tue Nov 18 22:00:48 EST 2025 Sat Nov 29 03:29:27 EST 2025 Fri Feb 21 02:40:02 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | 2023. Springer Nature Limited. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c541t-acce89adc2f3b2f59bdf4920221ec602d8d8f485c1e2ed37c7ddace749c175ca3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-0601-6383 0000-0003-3497-5888 0000-0002-9798-6018 0000-0002-9155-5882 0000-0002-6685-2586 0000-0001-6047-9592 0000-0003-0556-6196 0000-0001-6358-8380 0000-0002-1871-1850 0000-0002-6669-6069 0000-0003-1721-1616 0000-0002-0123-8905 0000-0003-0339-700X 0000-0003-2008-1365 0000-0003-3350-9682 0000-0003-0047-8103 |
| OpenAccessLink | https://doaj.org/article/8f35cd376f7a48a1b2f93578aa021be6 |
| PMID | 37770423 |
| PQID | 2869802661 |
| PQPubID | 546298 |
| PageCount | 25 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_8f35cd376f7a48a1b2f93578aa021be6 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10539325 proquest_miscellaneous_2870991568 proquest_journals_2869802661 pubmed_primary_37770423 crossref_primary_10_1038_s41467_023_41655_2 crossref_citationtrail_10_1038_s41467_023_41655_2 springer_journals_10_1038_s41467_023_41655_2 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-09-28 |
| PublicationDateYYYYMMDD | 2023-09-28 |
| PublicationDate_xml | – month: 09 year: 2023 text: 2023-09-28 day: 28 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature communications |
| PublicationTitleAbbrev | Nat Commun |
| PublicationTitleAlternate | Nat Commun |
| PublicationYear | 2023 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Ahmed (CR27) 2021; 27 Sampson, Richards, Choi, Fry, Bayliss (CR17) 2021; 22 Berman (CR31) 2000; 28 McLeod (CR68) 2021; 11 CR38 CR37 Lyons (CR29) 2023; 186 Latysheva, Babu (CR14) 2016; 44 Wootton, Federhen (CR76) 1996; 266 Grau, Grosse, Keilwagen (CR103) 2015; 31 Qin (CR18) 2021; 7 Wang (CR35) 2018; 174 Hariri, Weber, Olmsted (CR75) 1990; 147 Dannenhoffer-Lafage, Best (CR78) 2021; 125 Meszaros (CR90) 2020; 48 Schindelin (CR100) 2012; 9 Campen (CR73) 2008; 15 Newman (CR69) 2021; 11 Li (CR91) 2020; 48 CR47 Iconaru (CR49) 2015; 5 Dang, Reddy, Shokat, Soucek (CR56) 2017; 17 CR46 Kashiwagi (CR53) 2019; 44 Chong (CR28) 2018; 361 Tian (CR64) 2020; 21 Ning (CR89) 2020; 48 Meszaros, Erdos, Dosztanyi (CR81) 2018; 46 Sawle, Ghosh (CR83) 2015; 143 Klein (CR55) 2020; 368 Davis, Kaur, Moosa, Banerjee (CR10) 2021; 30 Tinevez (CR99) 2017; 115 Conicella, Zerze, Mittal, Fawzi (CR25) 2016; 24 Toombs (CR84) 2012; 109 CR54 O’Leary (CR66) 2016; 44 CR51 Békés, Langley, Crews (CR57) 2022; 21 Hardenberg, Horvath, Ambrus, Fuxreiter, Vendruscolo (CR41) 2020; 117 Hu (CR3) 2018; 46 Ren (CR52) 2005; 5 Holehouse, Das, Ahad, Richardson, Pappu (CR24) 2017; 112 Lu (CR43) 2020; 48 Ahn (CR6) 2021; 595 Saar (CR40) 2021; 118 CR65 Somjee, Mitrea, Kriwacki (CR33) 2020; 25 Das, Pappu (CR74) 2013; 110 Hyman, Weber, Julicher (CR21) 2014; 30 CR60 Krivtsov (CR59) 2019; 36 Lee (CR61) 2017; 45 Mitrea, Kriwacki (CR42) 2016; 14 Banani, Lee, Hyman, Rosen (CR20) 2017; 18 Schmidt, Rohatgi (CR26) 2016; 16 Brien, Stegmaier, Armstrong (CR2) 2019; 19 Shannon (CR45) 2003; 13 Sarkans (CR71) 2018; 46 You (CR88) 2020; 48 Jevtic (CR19) 2022; 41 Tweedie (CR93) 2021; 49 Bolognesi (CR39) 2016; 16 Stransky, Cerami, Schalm, Kim, Lengauer (CR5) 2014; 5 Martin (CR80) 2016; 138 Altschul (CR70) 1997; 25 Downing (CR67) 2012; 44 Xu (CR13) 2016; 30 Ban, Iconaru, Ramanathan, Zuo, Kriwacki (CR50) 2017; 139 Burge (CR44) 2012; 2012 Boulay (CR7) 2017; 171 Cheng (CR9) 2022; 13 CR8 Uversky (CR85) 2002; 11 Tulpule (CR16) 2021; 184 Kyte, Doolittle (CR77) 1982; 157 Brady (CR104) 2022; 54 Lancaster, Nutter-Upham, Lindquist, King (CR23) 2014; 30 Shirnekhi, Chandra, Kriwacki (CR48) 2023; 7 Ruff (CR32) 2022; 82 CR11 Ward (CR87) 1963; 58 CR97 Kim, Salzberg (CR62) 2011; 12 CR94 Mao, Crick, Vitalis, Chicoine, Pappu (CR79) 2010; 107 Jeha (CR105) 2021; 2 Auton, Holthauzen, Bolen (CR72) 2007; 104 Gao (CR1) 2018; 23 Vernon (CR22) 2018; 7 Latysheva (CR15) 2016; 63 UniProt (CR92) 2021; 49 Heikamp (CR58) 2022; 139 Klopfenstein (CR98) 2018; 8 Kim, Jang, Lee (CR63) 2019; 17 Blum (CR96) 2021; 49 CR102 Zheng, Dignon, Brown, Kim, Mittal (CR86) 2020; 11 Jones (CR95) 2014; 30 CR101 Terlecki-Zaniewicz (CR12) 2021; 28 Gu (CR4) 2019; 51 Suzuki, Shimodaira (CR34) 2006; 22 Taylor, Wei, Stone, Brangwynne (CR36) 2019; 117 Nott (CR30) 2015; 57 Nguyen Ba, Pogoutse, Provart, Moses (CR82) 2009; 10 41655_CR47 HK Shirnekhi (41655_CR48) 2023; 7 W Ning (41655_CR89) 2020; 48 C UniProt (41655_CR92) 2021; 49 M Békés (41655_CR57) 2022; 21 41655_CR46 D Ban (41655_CR50) 2017; 139 C McLeod (41655_CR68) 2021; 11 J Wang (41655_CR35) 2018; 174 R Suzuki (41655_CR34) 2006; 22 41655_CR37 41655_CR38 U Sarkans (41655_CR71) 2018; 46 K You (41655_CR88) 2020; 48 AH Mao (41655_CR79) 2010; 107 SF Altschul (41655_CR70) 1997; 25 AA Hyman (41655_CR21) 2014; 30 M Auton (41655_CR72) 2007; 104 41655_CR101 DM Mitrea (41655_CR42) 2016; 14 H Xu (41655_CR13) 2016; 30 P Jones (41655_CR95) 2014; 30 41655_CR102 QS Gao (41655_CR1) 2018; 23 41655_CR8 AE Conicella (41655_CR25) 2016; 24 EB Heikamp (41655_CR58) 2022; 139 M Hardenberg (41655_CR41) 2020; 117 T Dannenhoffer-Lafage (41655_CR78) 2021; 125 S Burge (41655_CR44) 2012; 2012 JH Ahn (41655_CR6) 2021; 595 KM Ruff (41655_CR32) 2022; 82 X Hu (41655_CR3) 2018; 46 Z Gu (41655_CR4) 2019; 51 S Terlecki-Zaniewicz (41655_CR12) 2021; 28 NO Taylor (41655_CR36) 2019; 117 AV Krivtsov (41655_CR59) 2019; 36 41655_CR94 AN Nguyen Ba (41655_CR82) 2009; 10 W Zheng (41655_CR86) 2020; 11 41655_CR97 41655_CR11 TJ Nott (41655_CR30) 2015; 57 JR Downing (41655_CR67) 2012; 44 S Kashiwagi (41655_CR53) 2019; 44 J Schindelin (41655_CR100) 2012; 9 L Tian (41655_CR64) 2020; 21 B Bolognesi (41655_CR39) 2016; 16 NA O’Leary (41655_CR66) 2016; 44 P Shannon (41655_CR45) 2003; 13 NS Ahmed (41655_CR27) 2021; 27 NS Latysheva (41655_CR14) 2016; 44 GL Brien (41655_CR2) 2019; 19 Y Cheng (41655_CR9) 2022; 13 KL Saar (41655_CR40) 2021; 118 Q Li (41655_CR91) 2020; 48 SW Brady (41655_CR104) 2022; 54 JY Tinevez (41655_CR99) 2017; 115 Z Qin (41655_CR18) 2021; 7 M Blum (41655_CR96) 2021; 49 LI Iconaru (41655_CR49) 2015; 5 R Somjee (41655_CR33) 2020; 25 M Lee (41655_CR61) 2017; 45 HB Schmidt (41655_CR26) 2016; 16 RM Vernon (41655_CR22) 2018; 7 J Sampson (41655_CR17) 2021; 22 AK Lancaster (41655_CR23) 2014; 30 JA Toombs (41655_CR84) 2012; 109 G Boulay (41655_CR7) 2017; 171 S Chong (41655_CR28) 2018; 361 HM Berman (41655_CR31) 2000; 28 N Stransky (41655_CR5) 2014; 5 B Meszaros (41655_CR90) 2020; 48 H Lyons (41655_CR29) 2023; 186 VN Uversky (41655_CR85) 2002; 11 L Sawle (41655_CR83) 2015; 143 A Hariri (41655_CR75) 1990; 147 S Newman (41655_CR69) 2021; 11 Z Jevtic (41655_CR19) 2022; 41 JC Wootton (41655_CR76) 1996; 266 41655_CR65 S Jeha (41655_CR105) 2021; 2 RK Das (41655_CR74) 2013; 110 S Lu (41655_CR43) 2020; 48 EW Martin (41655_CR80) 2016; 138 A Tulpule (41655_CR16) 2021; 184 AS Holehouse (41655_CR24) 2017; 112 41655_CR60 S Tweedie (41655_CR93) 2021; 49 B Meszaros (41655_CR81) 2018; 46 NS Latysheva (41655_CR15) 2016; 63 DV Klopfenstein (41655_CR98) 2018; 8 J Grau (41655_CR103) 2015; 31 A Campen (41655_CR73) 2008; 15 41655_CR51 D Kim (41655_CR62) 2011; 12 41655_CR54 SF Banani (41655_CR20) 2017; 18 P Kim (41655_CR63) 2019; 17 R Ren (41655_CR52) 2005; 5 CV Dang (41655_CR56) 2017; 17 J Kyte (41655_CR77) 1982; 157 RB Davis (41655_CR10) 2021; 30 IA Klein (41655_CR55) 2020; 368 JH Ward Jr (41655_CR87) 1963; 58 |
| References_xml | – volume: 266 start-page: 554 year: 1996 end-page: 571 ident: CR76 article-title: Analysis of compositionally biased regions in sequence databases publication-title: Methods Enzymol. – volume: 21 start-page: 181 year: 2022 end-page: 200 ident: CR57 article-title: PROTAC targeted protein degraders: the past is prologue publication-title: Nat. Rev. Drug Discov. – ident: CR97 – volume: 13 year: 2022 ident: CR9 article-title: Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas publication-title: Nat. Commun. – ident: CR51 – volume: 48 start-page: D288 year: 2020 end-page: D295 ident: CR89 article-title: DrLLPS: a data resource of liquid-liquid phase separation in eukaryotes publication-title: Nucleic Acids Res. – volume: 17 start-page: e26 year: 2019 ident: CR63 article-title: FusionScan: accurate prediction of fusion genes from RNA-Seq data publication-title: Genomics Inf. – volume: 186 start-page: 327 year: 2023 end-page: 345.e328 ident: CR29 article-title: Functional partitioning of transcriptional regulators by patterned charge blocks publication-title: Cell – ident: CR54 – volume: 58 start-page: 236 year: 1963 end-page: 244 ident: CR87 article-title: Hierarchical grouping to optimize an objective function publication-title: J. Am. Stat. Assoc. – volume: 2 start-page: 326 year: 2021 end-page: 337 ident: CR105 article-title: Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy publication-title: Blood Cancer Discov. – ident: CR8 – volume: 23 start-page: 227 year: 2018 end-page: 238.e223 ident: CR1 article-title: Driver fusions and their implications in the development and treatment of human cancers publication-title: Cell Rep. – volume: 11 start-page: 739 year: 2002 end-page: 756 ident: CR85 article-title: Natively unfolded proteins: a point where biology waits for physics publication-title: Protein Sci. – volume: 41 start-page: 34 year: 2022 ident: CR19 article-title: SMARCA5 interacts with NUP98-NSD1 oncofusion protein and sustains hematopoietic cells transformation publication-title: J. Exp. Clin. Cancer Res. – volume: 51 start-page: 296 year: 2019 end-page: 307 ident: CR4 article-title: PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia publication-title: Nat. Genet. – ident: CR101 – volume: 30 start-page: 2501 year: 2014 end-page: 2502 ident: CR23 article-title: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition publication-title: Bioinformatics – volume: 48 start-page: D360 year: 2020 end-page: D367 ident: CR90 article-title: PhaSePro: the database of proteins driving liquid-liquid phase separation publication-title: Nucleic Acids Res. – volume: 117 start-page: 1285 year: 2019 end-page: 1300 ident: CR36 article-title: Quantifying dynamics in phase-separated condensates using fluorescence recovery after photobleaching publication-title: Biophys. J. – volume: 28 start-page: 190 year: 2021 end-page: 201 ident: CR12 article-title: Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression publication-title: Nat. Struct. Mol. Biol. – volume: 5 start-page: 172 year: 2005 end-page: 183 ident: CR52 article-title: Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia publication-title: Nat. Rev. Cancer – volume: 14 year: 2016 ident: CR42 article-title: Phase separation in biology; functional organization of a higher order publication-title: Cell Commun. Signal. – volume: 9 start-page: 676 year: 2012 end-page: 682 ident: CR100 article-title: Fiji: an open-source platform for biological-image analysis publication-title: Nat. Methods – ident: CR11 – volume: 30 start-page: 1236 year: 2014 end-page: 1240 ident: CR95 article-title: InterProScan 5: genome-scale protein function classification publication-title: Bioinformatics – ident: CR60 – volume: 17 start-page: 502 year: 2017 end-page: 508 ident: CR56 article-title: Drugging the ‘undruggable’ cancer targets publication-title: Nat. Rev. Cancer – volume: 48 start-page: D354 year: 2020 end-page: D359 ident: CR88 article-title: PhaSepDB: a database of liquid-liquid phase separation related proteins publication-title: Nucleic Acids Res. – volume: 104 start-page: 15317 year: 2007 end-page: 15322 ident: CR72 article-title: Anatomy of energetic changes accompanying urea-induced protein denaturation publication-title: Proc. Natl Acad. Sci. USA – volume: 13 start-page: 2498 year: 2003 end-page: 2504 ident: CR45 article-title: Cytoscape: a software environment for integrated models of biomolecular interaction networks publication-title: Genome Res. – volume: 138 start-page: 15323 year: 2016 end-page: 15335 ident: CR80 article-title: Sequence determinants of the conformational properties of an intrinsically disordered protein prior to and upon multisite phosphorylation publication-title: J. Am. Chem. Soc. – ident: CR47 – volume: 368 start-page: 1386 year: 2020 end-page: 1392 ident: CR55 article-title: Partitioning of cancer therapeutics in nuclear condensates publication-title: Science – volume: 595 start-page: 591 year: 2021 end-page: 595 ident: CR6 article-title: Phase separation drives aberrant chromatin looping and cancer development publication-title: Nature – volume: 63 start-page: 579 year: 2016 end-page: 592 ident: CR15 article-title: Molecular principles of gene fusion mediated rewiring of protein interaction networks in cancer publication-title: Mol. Cell – volume: 54 start-page: 1376 year: 2022 end-page: 1389 ident: CR104 article-title: The genomic landscape of pediatric acute lymphoblastic leukemia publication-title: Nat. Genet. – volume: 15 start-page: 956 year: 2008 end-page: 963 ident: CR73 article-title: TOP-IDP-scale: a new amino acid scale measuring propensity for intrinsic disorder publication-title: Protein Pept. Lett. – volume: 5 year: 2014 ident: CR5 article-title: The landscape of kinase fusions in cancer publication-title: Nat. Commun. – volume: 8 year: 2018 ident: CR98 article-title: GOATOOLS: a Python library for Gene Ontology analyses publication-title: Sci. Rep. – volume: 30 start-page: 1454 year: 2021 end-page: 1466 ident: CR10 article-title: FUS oncofusion protein condensates recruit mSWI/SNF chromatin remodeler via heterotypic interactions between prion-like domains publication-title: Protein Sci. – volume: 25 start-page: 3389 year: 1997 end-page: 3402 ident: CR70 article-title: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs publication-title: Nucleic Acids Res. – volume: 22 start-page: 1540 year: 2006 end-page: 1542 ident: CR34 article-title: Pvclust: an R package for assessing the uncertainty in hierarchical clustering publication-title: Bioinformatics – volume: 125 start-page: 4046 year: 2021 end-page: 4056 ident: CR78 article-title: A data-driven hydrophobicity scale for predicting liquid-liquid phase separation of proteins publication-title: J. Phys. Chem. B – volume: 174 start-page: 688 year: 2018 end-page: 699.e616 ident: CR35 article-title: A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins publication-title: Cell – volume: 16 start-page: 1228 year: 2016 end-page: 1236 ident: CR26 article-title: In vivo formation of vacuolated multi-phase compartments lacking membranes publication-title: Cell Rep. – volume: 5 year: 2015 ident: CR49 article-title: Discovery of small molecules that inhibit the disordered protein, p27(Kip1) publication-title: Sci. Rep. – volume: 46 start-page: D1144 year: 2018 end-page: D1149 ident: CR3 article-title: TumorFusions: an integrative resource for cancer-associated transcript fusions publication-title: Nucleic Acids Res. – ident: CR94 – volume: 44 start-page: 4487 year: 2016 end-page: 4503 ident: CR14 article-title: Discovering and understanding oncogenic gene fusions through data intensive computational approaches publication-title: Nucleic Acids Res. – volume: 48 start-page: D265 year: 2020 end-page: D268 ident: CR43 article-title: CDD/SPARCLE: the conserved domain database in 2020 publication-title: Nucleic Acids Res. – volume: 10 year: 2009 ident: CR82 article-title: NLStradamus: a simple Hidden Markov Model for nuclear localization signal prediction publication-title: BMC Bioinform. – volume: 46 start-page: D1266 year: 2018 end-page: D1270 ident: CR71 article-title: The BioStudies database-one stop shop for all data supporting a life sciences study publication-title: Nucleic Acids Res. – volume: 171 start-page: 163 year: 2017 end-page: 178.e119 ident: CR7 article-title: Cancer-specific retargeting of BAF complexes by a prion-like domain publication-title: Cell – ident: CR38 – volume: 82 start-page: 3193 year: 2022 end-page: 3208.e3198 ident: CR32 article-title: Sequence grammar underlying the unfolding and phase separation of globular proteins publication-title: Mol. Cell – volume: 115 start-page: 80 year: 2017 end-page: 90 ident: CR99 article-title: TrackMate: an open and extensible platform for single-particle tracking publication-title: Methods – volume: 30 start-page: 39 year: 2014 end-page: 58 ident: CR21 article-title: Liquid-liquid phase separation in biology publication-title: Annu. Rev. Cell Dev. Biol. – volume: 139 start-page: 13692 year: 2017 end-page: 13700 ident: CR50 article-title: A small molecule causes a population shift in the conformational landscape of an intrinsically disordered protein publication-title: J. Am. Chem. Soc. – volume: 57 start-page: 936 year: 2015 end-page: 947 ident: CR30 article-title: Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles publication-title: Mol. Cell – volume: 22 start-page: e53693 year: 2021 ident: CR17 article-title: Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation publication-title: EMBO Rep. – volume: 117 start-page: 33254 year: 2020 end-page: 33262 ident: CR41 article-title: Widespread occurrence of the droplet state of proteins in the human proteome publication-title: Proc. Natl Acad. Sci. USA – ident: CR102 – volume: 157 start-page: 105 year: 1982 end-page: 132 ident: CR77 article-title: A simple method for displaying the hydropathic character of a protein publication-title: J. Mol. Biol. – volume: 25 start-page: 207 year: 2020 end-page: 218 ident: CR33 article-title: Exploring relationships between the density of charged tracts within disordered regions and phase separation publication-title: Pac. Symp. Biocomput. – volume: 12 year: 2011 ident: CR62 article-title: TopHat-Fusion: an algorithm for discovery of novel fusion transcripts publication-title: Genome Biol. – volume: 48 start-page: D320 year: 2020 end-page: D327 ident: CR91 article-title: LLPSDB: a database of proteins undergoing liquid-liquid phase separation in vitro publication-title: Nucleic Acids Res. – volume: 36 start-page: 660 year: 2019 end-page: 673.e611 ident: CR59 article-title: A Menin-MLL inhibitor induces specific chromatin changes and eradicates disease in models of MLL-rearranged leukemia publication-title: Cancer Cell – volume: 49 start-page: D939 year: 2021 end-page: D946 ident: CR93 article-title: Genenames.org: the HGNC and VGNC resources in 2021 publication-title: Nucleic Acids Res. – volume: 143 start-page: 085101 year: 2015 ident: CR83 article-title: A theoretical method to compute sequence dependent configurational properties in charged polymers and proteins publication-title: J. Chem. Phys. – volume: 49 start-page: D344 year: 2021 end-page: D354 ident: CR96 article-title: The InterPro protein families and domains database: 20 years on publication-title: Nucleic Acids Res. – volume: 31 start-page: 2595 year: 2015 end-page: 2597 ident: CR103 article-title: PRROC: computing and visualizing precision-recall and receiver operating characteristic curves in R publication-title: Bioinformatics – ident: CR46 – volume: 30 start-page: 863 year: 2016 end-page: 878 ident: CR13 article-title: NUP98 fusion proteins interact with the NSL and MLL1 complexes to drive leukemogenesis publication-title: Cancer Cell – volume: 147 start-page: 235 year: 1990 end-page: 254 ident: CR75 article-title: On the validity of Shannon-information calculations for molecular biological sequences publication-title: J. Theor. Biol. – volume: 49 start-page: D480 year: 2021 end-page: D489 ident: CR92 article-title: UniProt: the universal protein knowledgebase in 2021 publication-title: Nucleic Acids Res. – volume: 27 start-page: 920 year: 2021 end-page: 932 ident: CR27 article-title: Fusion protein EWS-FLI1 is incorporated into a protein granule in cells publication-title: RNA – volume: 28 start-page: 235 year: 2000 end-page: 242 ident: CR31 article-title: The protein data bank publication-title: Nucleic Acids Res. – volume: 139 start-page: 894 year: 2022 end-page: 906 ident: CR58 article-title: The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML publication-title: Blood – volume: 7 start-page: 33 year: 2021 ident: CR18 article-title: Phase separation of EML4-ALK in firing downstream signaling and promoting lung tumorigenesis publication-title: Cell Discov. – volume: 44 start-page: 619 year: 2012 end-page: 622 ident: CR67 article-title: The pediatric cancer genome project publication-title: Nat. Genet – volume: 7 start-page: e31486 year: 2018 ident: CR22 article-title: Pi-Pi contacts are an overlooked protein feature relevant to phase separation publication-title: Elife – volume: 112 start-page: 16 year: 2017 end-page: 21 ident: CR24 article-title: CIDER: resources to analyze sequence-ensemble relationships of intrinsically disordered proteins publication-title: Biophys. J. – volume: 2012 start-page: bar068 year: 2012 ident: CR44 article-title: Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation publication-title: Database – volume: 19 start-page: 255 year: 2019 end-page: 269 ident: CR2 article-title: Targeting chromatin complexes in fusion protein-driven malignancies publication-title: Nat. Rev. Cancer – volume: 361 start-page: eaar2555 year: 2018 ident: CR28 article-title: Imaging dynamic and selective low-complexity domain interactions that control gene transcription publication-title: Science – volume: 44 start-page: 195 year: 2019 end-page: 204 ident: CR53 article-title: Localization of BCR-ABL to stress granules contributes to its oncogenic function publication-title: Cell Struct. Funct. – volume: 118 start-page: e2019053118 year: 2021 ident: CR40 article-title: Learning the molecular grammar of protein condensates from sequence determinants and embeddings publication-title: Proc. Natl Acad. Sci. USA – ident: CR37 – volume: 45 start-page: D784 year: 2017 end-page: D789 ident: CR61 article-title: ChimerDB 3.0: an enhanced database for fusion genes from cancer transcriptome and literature data mining publication-title: Nucleic Acids Res. – volume: 18 start-page: 285 year: 2017 end-page: 298 ident: CR20 article-title: Biomolecular condensates: organizers of cellular biochemistry publication-title: Nat. Rev. Mol. Cell Biol. – volume: 11 start-page: 3408 year: 2020 end-page: 3415 ident: CR86 article-title: Hydropathy patterning complements charge patterning to describe conformational preferences of disordered proteins publication-title: J. Phys. Chem. Lett. – volume: 109 start-page: 6519 year: 2012 end-page: 6524 ident: CR84 article-title: De novo design of synthetic prion domains publication-title: Proc. Natl Acad. Sci. USA – volume: 46 start-page: W329 year: 2018 end-page: W337 ident: CR81 article-title: IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding publication-title: Nucleic Acids Res. – volume: 16 start-page: 222 year: 2016 end-page: 231 ident: CR39 article-title: A concentration-dependent liquid phase separation can cause toxicity upon increased protein expression publication-title: Cell Rep. – volume: 24 start-page: 1537 year: 2016 end-page: 1549 ident: CR25 article-title: ALS mutations disrupt phase separation mediated by alpha-helical structure in the TDP-43 low-complexity C-terminal domain publication-title: Structure – volume: 107 start-page: 8183 year: 2010 end-page: 8188 ident: CR79 article-title: Net charge per residue modulates conformational ensembles of intrinsically disordered proteins publication-title: Proc. Natl Acad. Sci. USA – ident: CR65 – volume: 110 start-page: 13392 year: 2013 end-page: 13397 ident: CR74 article-title: Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues publication-title: Proc. Natl Acad. Sci. USA – volume: 11 start-page: 1082 year: 2021 end-page: 1099 ident: CR68 article-title: St. Jude cloud: a pediatric cancer genomic data-sharing ecosystem publication-title: Cancer Discov. – volume: 184 start-page: 2649 year: 2021 end-page: 2664.e2618 ident: CR16 article-title: Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules publication-title: Cell – volume: 11 start-page: 3008 year: 2021 end-page: 3027 ident: CR69 article-title: Genomes for kids: the scope of pathogenic mutations in pediatric cancer revealed by comprehensive DNA and RNA sequencing publication-title: Cancer Discov. – volume: 21 year: 2020 ident: CR64 article-title: CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data publication-title: Genome Biol. – volume: 44 start-page: D733 year: 2016 end-page: D745 ident: CR66 article-title: Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation publication-title: Nucleic Acids Res. – volume: 7 start-page: 73 year: 2023 end-page: 91 ident: CR48 article-title: The role of phase separated condensates in fusion oncoprotein driven cancers publication-title: Annu. Rev. Cancer Biol. – volume: 28 start-page: 235 year: 2000 ident: 41655_CR31 publication-title: Nucleic Acids Res. doi: 10.1093/nar/28.1.235 – volume: 139 start-page: 894 year: 2022 ident: 41655_CR58 publication-title: Blood doi: 10.1182/blood.2021012806 – volume: 15 start-page: 956 year: 2008 ident: 41655_CR73 publication-title: Protein Pept. Lett. doi: 10.2174/092986608785849164 – volume: 58 start-page: 236 year: 1963 ident: 41655_CR87 publication-title: J. Am. Stat. Assoc. doi: 10.1080/01621459.1963.10500845 – volume: 48 start-page: D360 year: 2020 ident: 41655_CR90 publication-title: Nucleic Acids Res. – ident: 41655_CR101 doi: 10.1038/s41592-022-01507-1 – volume: 31 start-page: 2595 year: 2015 ident: 41655_CR103 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv153 – volume: 49 start-page: D344 year: 2021 ident: 41655_CR96 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkaa977 – volume: 11 start-page: 3408 year: 2020 ident: 41655_CR86 publication-title: J. Phys. Chem. Lett. doi: 10.1021/acs.jpclett.0c00288 – volume: 147 start-page: 235 year: 1990 ident: 41655_CR75 publication-title: J. Theor. Biol. doi: 10.1016/S0022-5193(05)80054-2 – volume: 30 start-page: 2501 year: 2014 ident: 41655_CR23 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu310 – ident: 41655_CR38 – volume: 21 year: 2020 ident: 41655_CR64 publication-title: Genome Biol. doi: 10.1186/s13059-020-02043-x – volume: 7 start-page: 73 year: 2023 ident: 41655_CR48 publication-title: Annu. Rev. Cancer Biol. doi: 10.1146/annurev-cancerbio-061421-122050 – volume: 10 year: 2009 ident: 41655_CR82 publication-title: BMC Bioinform. doi: 10.1186/1471-2105-10-202 – volume: 2012 start-page: bar068 year: 2012 ident: 41655_CR44 publication-title: Database – ident: 41655_CR97 doi: 10.1093/database/baw027 – volume: 109 start-page: 6519 year: 2012 ident: 41655_CR84 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1119366109 – volume: 138 start-page: 15323 year: 2016 ident: 41655_CR80 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.6b10272 – volume: 110 start-page: 13392 year: 2013 ident: 41655_CR74 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1304749110 – ident: 41655_CR51 doi: 10.1126/sciadv.abb5924 – volume: 49 start-page: D939 year: 2021 ident: 41655_CR93 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkaa980 – volume: 171 start-page: 163 year: 2017 ident: 41655_CR7 publication-title: Cell doi: 10.1016/j.cell.2017.07.036 – volume: 143 start-page: 085101 year: 2015 ident: 41655_CR83 publication-title: J. Chem. Phys. doi: 10.1063/1.4929391 – volume: 18 start-page: 285 year: 2017 ident: 41655_CR20 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2017.7 – volume: 21 start-page: 181 year: 2022 ident: 41655_CR57 publication-title: Nat. Rev. Drug Discov. doi: 10.1038/s41573-021-00371-6 – volume: 44 start-page: 4487 year: 2016 ident: 41655_CR14 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw282 – volume: 157 start-page: 105 year: 1982 ident: 41655_CR77 publication-title: J. Mol. Biol. doi: 10.1016/0022-2836(82)90515-0 – volume: 30 start-page: 1236 year: 2014 ident: 41655_CR95 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu031 – volume: 82 start-page: 3193 year: 2022 ident: 41655_CR32 publication-title: Mol. Cell doi: 10.1016/j.molcel.2022.06.024 – volume: 2 start-page: 326 year: 2021 ident: 41655_CR105 publication-title: Blood Cancer Discov. doi: 10.1158/2643-3230.BCD-20-0229 – volume: 48 start-page: D265 year: 2020 ident: 41655_CR43 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz991 – volume: 30 start-page: 39 year: 2014 ident: 41655_CR21 publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev-cellbio-100913-013325 – volume: 104 start-page: 15317 year: 2007 ident: 41655_CR72 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0706251104 – ident: 41655_CR37 – volume: 51 start-page: 296 year: 2019 ident: 41655_CR4 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0315-5 – volume: 13 year: 2022 ident: 41655_CR9 publication-title: Nat. Commun. – volume: 7 start-page: 33 year: 2021 ident: 41655_CR18 publication-title: Cell Discov. doi: 10.1038/s41421-021-00270-5 – volume: 13 start-page: 2498 year: 2003 ident: 41655_CR45 publication-title: Genome Res. doi: 10.1101/gr.1239303 – volume: 5 year: 2014 ident: 41655_CR5 publication-title: Nat. Commun. doi: 10.1038/ncomms5846 – volume: 48 start-page: D320 year: 2020 ident: 41655_CR91 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz778 – volume: 30 start-page: 863 year: 2016 ident: 41655_CR13 publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.10.019 – volume: 23 start-page: 227 year: 2018 ident: 41655_CR1 publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.03.050 – volume: 112 start-page: 16 year: 2017 ident: 41655_CR24 publication-title: Biophys. J. doi: 10.1016/j.bpj.2016.11.3200 – volume: 16 start-page: 222 year: 2016 ident: 41655_CR39 publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.05.076 – ident: 41655_CR54 doi: 10.1101/2022.12.19.521099 – volume: 266 start-page: 554 year: 1996 ident: 41655_CR76 publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(96)66035-2 – volume: 361 start-page: eaar2555 year: 2018 ident: 41655_CR28 publication-title: Science doi: 10.1126/science.aar2555 – volume: 30 start-page: 1454 year: 2021 ident: 41655_CR10 publication-title: Protein Sci. doi: 10.1002/pro.4127 – volume: 48 start-page: D288 year: 2020 ident: 41655_CR89 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz1027 – volume: 41 start-page: 34 year: 2022 ident: 41655_CR19 publication-title: J. Exp. Clin. Cancer Res. doi: 10.1186/s13046-022-02248-x – volume: 63 start-page: 579 year: 2016 ident: 41655_CR15 publication-title: Mol. Cell doi: 10.1016/j.molcel.2016.07.008 – ident: 41655_CR60 doi: 10.1038/s41418-022-00955-8 – volume: 44 start-page: D733 year: 2016 ident: 41655_CR66 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv1189 – volume: 17 start-page: 502 year: 2017 ident: 41655_CR56 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc.2017.36 – volume: 44 start-page: 195 year: 2019 ident: 41655_CR53 publication-title: Cell Struct. Funct. doi: 10.1247/csf.19033 – volume: 44 start-page: 619 year: 2012 ident: 41655_CR67 publication-title: Nat. Genet doi: 10.1038/ng.2287 – volume: 115 start-page: 80 year: 2017 ident: 41655_CR99 publication-title: Methods doi: 10.1016/j.ymeth.2016.09.016 – volume: 25 start-page: 3389 year: 1997 ident: 41655_CR70 publication-title: Nucleic Acids Res. doi: 10.1093/nar/25.17.3389 – volume: 17 start-page: e26 year: 2019 ident: 41655_CR63 publication-title: Genomics Inf. doi: 10.5808/GI.2019.17.3.e26 – volume: 7 start-page: e31486 year: 2018 ident: 41655_CR22 publication-title: Elife doi: 10.7554/eLife.31486 – volume: 24 start-page: 1537 year: 2016 ident: 41655_CR25 publication-title: Structure doi: 10.1016/j.str.2016.07.007 – ident: 41655_CR8 doi: 10.1158/2159-8290.CD-21-0674 – volume: 5 start-page: 172 year: 2005 ident: 41655_CR52 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1567 – volume: 8 year: 2018 ident: 41655_CR98 publication-title: Sci. Rep. doi: 10.1038/s41598-018-28948-z – volume: 54 start-page: 1376 year: 2022 ident: 41655_CR104 publication-title: Nat. Genet. doi: 10.1038/s41588-022-01159-z – volume: 19 start-page: 255 year: 2019 ident: 41655_CR2 publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0132-x – volume: 186 start-page: 327 year: 2023 ident: 41655_CR29 publication-title: Cell doi: 10.1016/j.cell.2022.12.013 – volume: 11 start-page: 739 year: 2002 ident: 41655_CR85 publication-title: Protein Sci. doi: 10.1110/ps.4210102 – volume: 14 year: 2016 ident: 41655_CR42 publication-title: Cell Commun. Signal. doi: 10.1186/s12964-015-0125-7 – volume: 107 start-page: 8183 year: 2010 ident: 41655_CR79 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0911107107 – volume: 16 start-page: 1228 year: 2016 ident: 41655_CR26 publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.06.088 – volume: 25 start-page: 207 year: 2020 ident: 41655_CR33 publication-title: Pac. Symp. Biocomput. – volume: 57 start-page: 936 year: 2015 ident: 41655_CR30 publication-title: Mol. Cell doi: 10.1016/j.molcel.2015.01.013 – volume: 46 start-page: D1266 year: 2018 ident: 41655_CR71 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx965 – volume: 12 year: 2011 ident: 41655_CR62 publication-title: Genome Biol. – volume: 595 start-page: 591 year: 2021 ident: 41655_CR6 publication-title: Nature doi: 10.1038/s41586-021-03662-5 – ident: 41655_CR11 doi: 10.1242/jcs.258578 – ident: 41655_CR46 doi: 10.1126/science.aar3958 – volume: 368 start-page: 1386 year: 2020 ident: 41655_CR55 publication-title: Science doi: 10.1126/science.aaz4427 – volume: 48 start-page: D354 year: 2020 ident: 41655_CR88 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz847 – volume: 11 start-page: 1082 year: 2021 ident: 41655_CR68 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-20-1230 – volume: 184 start-page: 2649 year: 2021 ident: 41655_CR16 publication-title: Cell doi: 10.1016/j.cell.2021.03.031 – volume: 11 start-page: 3008 year: 2021 ident: 41655_CR69 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-20-1631 – volume: 46 start-page: D1144 year: 2018 ident: 41655_CR3 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx1018 – volume: 117 start-page: 33254 year: 2020 ident: 41655_CR41 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.2007670117 – volume: 174 start-page: 688 year: 2018 ident: 41655_CR35 publication-title: Cell doi: 10.1016/j.cell.2018.06.006 – ident: 41655_CR47 doi: 10.1016/j.cell.2018.10.042 – ident: 41655_CR65 doi: 10.1093/nar/gkac240 – volume: 45 start-page: D784 year: 2017 ident: 41655_CR61 publication-title: Nucleic Acids Res. – volume: 49 start-page: D480 year: 2021 ident: 41655_CR92 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkaa1100 – ident: 41655_CR94 – volume: 139 start-page: 13692 year: 2017 ident: 41655_CR50 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.7b01380 – volume: 125 start-page: 4046 year: 2021 ident: 41655_CR78 publication-title: J. Phys. Chem. B doi: 10.1021/acs.jpcb.0c11479 – volume: 46 start-page: W329 year: 2018 ident: 41655_CR81 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky384 – volume: 28 start-page: 190 year: 2021 ident: 41655_CR12 publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/s41594-020-00550-w – volume: 5 year: 2015 ident: 41655_CR49 publication-title: Sci. Rep. doi: 10.1038/srep15686 – volume: 117 start-page: 1285 year: 2019 ident: 41655_CR36 publication-title: Biophys. J. doi: 10.1016/j.bpj.2019.08.030 – volume: 36 start-page: 660 year: 2019 ident: 41655_CR59 publication-title: Cancer Cell doi: 10.1016/j.ccell.2019.11.001 – volume: 22 start-page: 1540 year: 2006 ident: 41655_CR34 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl117 – volume: 118 start-page: e2019053118 year: 2021 ident: 41655_CR40 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.2019053118 – ident: 41655_CR102 doi: 10.1093/bib/bbaa408 – volume: 9 start-page: 676 year: 2012 ident: 41655_CR100 publication-title: Nat. Methods doi: 10.1038/nmeth.2019 – volume: 22 start-page: e53693 year: 2021 ident: 41655_CR17 publication-title: EMBO Rep. doi: 10.15252/embr.202153693 – volume: 27 start-page: 920 year: 2021 ident: 41655_CR27 publication-title: RNA doi: 10.1261/rna.078827.121 |
| SSID | ssj0000391844 |
| Score | 2.5849779 |
| Snippet | Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis... Abstract Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 6008 |
| SubjectTerms | 13/106 14/19 631/114/663/2009 631/57/2269 Biomolecular Condensates Carcinogenesis Cell signaling Cell Transformation, Neoplastic Chromosome translocations Condensates Condensation Cytoplasm Functionals Gene expression HeLa Cells Humanities and Social Sciences Humans Liquid phases Localization Machine learning multidisciplinary Oncogene Proteins, Fusion Oncoproteins Phase separation Reagents Science Science (multidisciplinary) Tumorigenesis |
| SummonAdditionalLinks | – databaseName: Advanced Technologies & Aerospace Database dbid: P5Z link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BAYkLb2igoCBxg6gbP-LxCfGqOFU9gFRxsRw_YCWUlM1uJf49Yyebann0wmUPG0fyeF6fPc43AC-ij7Rfa5pKNJ5-bIiVjoyCoWiiki0XLYu52YQ6PsbTU30yHbgN07XKbUzMgdr3Lp2RHzJsNC5SOnl99qNKXaNSdXVqoXEVriWWhOSYJ_LLfMaS2M9RiOlbmQXHw0HkyECJqiIkImXFdvJRpu3_G9b888rkb3XTnI6Obv-vIHfg1gREyzej5dyFK6G7BzfG1pQ_7wO-DzH3jigJIZa0aab4NBAuLfO3wenWVNnHMm7SYVvZd67PhA_LbngAn48-fHr3sZq6LFROinpdWecCausdi5wUI3Xro9CMcnsdXLNgHj1GgdLVgQXPlVPeWxeU0I6gh7P8Iex1fRf2ofScK4WSQAV60WqvZRsWhA8dWudbxALq7VobN1GQp04Y300uhXM0o34M6cdk_RhWwMv5nbORgOPS0W-TCueRiTw7_9GvvprJFw1GLh1JQtZoBdqapNaJ9MdaAjxtaAo42GrOTB49mAu1FfB8fky-mAostgv9Jo1RBLhpR0ySPhrtZZ4JrYxKd5AKwB1L2pnq7pNu-S3zfRME5gSzZQGvtkZ3Ma9_r8Xjy8V4AjdZ8oNUYcMD2FuvNuEpXHfn6-WwepYd6RcQaSVs priority: 102 providerName: ProQuest |
| Title | Defining the condensate landscape of fusion oncoproteins |
| URI | https://link.springer.com/article/10.1038/s41467-023-41655-2 https://www.ncbi.nlm.nih.gov/pubmed/37770423 https://www.proquest.com/docview/2869802661 https://www.proquest.com/docview/2870991568 https://pubmed.ncbi.nlm.nih.gov/PMC10539325 https://doaj.org/article/8f35cd376f7a48a1b2f93578aa021be6 |
| Volume | 14 |
| WOSCitedRecordID | wos001080410400020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: P5Z dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M7P dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: BENPR dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: 7X7 dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: PIMPY dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwEB7BAhIXxJvAUgWJG0TbxHY8PrKwKzhQRQikwsVy_NBWQgnatEj8e8ZOWrY8L1x8qB3J_Tz2fBNPvgF4GlygeK2uC147aowPhQoVHYa8DlK0jLdVSMUm5GKBy6VqLpT6ijlhozzwCNwRBiaso20QpOFoSnpWRYUWY8g7tT6JbRPruRBMpTOYKQpd-PSVzJzh0cDTmUAuqiAOIkRR7XmiJNj_O5b5a7LkTzemyRGd3oQbE4PMX4wzvwWXfHcbro01Jb_dAXzlQyr6kBO1yynapYNlIEKZp496Y7pT3oc8bOJbsrzvbJ-UGlbdcBc-nJ68f_m6mMojFFbwcl0Yaz0q42wVGKEiVOsCVxU55dLbel45dBg4Clv6yhOCVjpnrJdcWeIM1rB7cND1nX8AuWNMShTEBtDxVjklWj8nYmfRWNciZlBuodJ20g6PJSw-63SHzVCP8GqCVyd4dZXBs90zX0bljL-OPo4rsBsZVa_TD2QLerIF_S9byOBwu3562oqDrrBWOI88JIMnu27aRPFmxHS-38QxkpgyhbL0T--Py72bCSEjY_JQBrhnCHtT3e_pVmdJqJu4KyN-LDJ4vrWZH_P6MxYP_wcWj-B6FY09XqDhIRyszzf-MVy1X9er4XwGl-VSphZncOX4ZNG8m6UdNIvJrw21jfhEPc2bt83H7_KYHls |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAioX3o9AgSDBCaJu_IidA0JAqVq1rDgUaW-u4wddCSVlswvqn-I3MnaSrZZHbz1w2cPGuxo7n-fhGc8H8Nxbj_FaUWSssPihnc9KT1AZssILXlFWER_JJsR4LCeT8tMa_BzuwoSyykEnRkVtGxPOyLeILEo5Cubkzcm3LLBGhezqQKHRwWLfnf7AkK19vbeN7_cFITsfDt_vZj2rQGY4y-eZNsbJUltDPEVBeFlZz0qCtix3phgRK630THKTO-IsFUZYq40TrDRoao2m-L-X4DLqcRFKyMRELM90Qrd1yVh_N2dE5VbLoiZCw5ih58N5RlbsX6QJ-Jtv-2eJ5m952mj-dm78bwt3E673jnb6ttsZt2DN1bfhake9eXoH5LbzkRsjRQ84NU0gAm7R707j3edQFZY2PvWLcJiYNrVpYkOLad3ehc8XIvY9WK-b2j2A1FIqhOToNEnLqtKWvHIj9H-N1MZWUiaQD-9Wmb7FemD6-Kpiqp9K1eFBIR5UxIMiCbxc_uakazBy7uh3ATLLkaE5ePyimX1Rva5R0lNucCa42zSTOsdZl6Gpkdbo0FWuSGBzQIrqNVarzmCSwLPlY9Q1IYGka9cswhiBAQVG_DjT-x0-l5LgyohQY5WAXEHuiqirT-rpcexnji4-xTCCJ_BqAPmZXP9ei4fnT-MpbOwefjxQB3vj_UdwjYQ9GLKJchPW57OFewxXzPf5tJ09iZs4haOLBv8vfrOF2g |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAhUX3o9AgSDBCaLdOHbsHBAClhVV0WoPIFVcXMcPuhJKymYX1L_Gr2PsPKrl0VsPXHJInGjsfJ75xh7PADx1xqG_lucJzQ1elHVJ4QgqQ5o7zsqMlsSFYhN8NhMHB8V8C372Z2F8WGWvE4OiNrX2a-QjIvJCjL05GbkuLGI-mb46_pb4ClJ-p7Uvp9FCZN-e_ED3rXm5N8F__YyQ6buPb98nXYWBRDOarhKltRWFMpq4DIViRWkcLQjatdTqfEyMMMJRwXRqiTUZ19wYpS2nhUazq1WG370AFzn6mN7xm7PPw_qOz7wuKO3O6YwzMWpo0EpoJBNkQYwlZMMWhpIBf-O5f4Zr_rZnG0zh9Nr_PIjX4WpHwOPX7Yy5AVu2ugmX25KcJ7dATKwLNTNiZMaxrn2B4Ab5eBzORPtosbh2sVv7Rca4rnQdEl0squY2fDoXse_AdlVX9h7EJss4FwzJlDC0LEzBSjtGXqyF0qYUIoK0_89Sd6nXfQWQrzKEAGRCttiQiA0ZsCFJBM-Hd47bxCNntn7j4TO09EnDw416-UV2OkgKlzGNPcFZqKhQKfa68MmOlEKiV9o8gt0eNbLTZI08hUwET4bHqIP8xpKqbL32bTg6GinLsad3W6wOkuDIcB97FYHYQPGGqJtPqsVRyHOO1D9D94JF8KIH_Klc_x6L-2d34zHsIOblh73Z_gO4Qvx09JuMYhe2V8u1fQiX9PfVolk-CvM5hsPzxv4vC3GOzQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Defining+the+condensate+landscape+of+fusion+oncoproteins&rft.jtitle=Nature+communications&rft.au=Swarnendu+Tripathi&rft.au=Hazheen+K.+Shirnekhi&rft.au=Scott+D.+Gorman&rft.au=Bappaditya+Chandra&rft.date=2023-09-28&rft.pub=Nature+Portfolio&rft.eissn=2041-1723&rft.volume=14&rft.issue=1&rft.spage=1&rft.epage=25&rft_id=info:doi/10.1038%2Fs41467-023-41655-2&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_8f35cd376f7a48a1b2f93578aa021be6 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon |