Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

The Carbohydrate Response Element Binding Protein (ChREBP) is a glucose-responsive transcription factor (TF) with two major splice isoforms (α and β). In chronic hyperglycemia and glucolipotoxicity, ChREBPα-mediated ChREBPβ expression surges, leading to insulin-secreting β-cell dedifferentiation and...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 2110 - 16
Main Authors:	Katz, Liora S., Visser, Emira J., Plitzko, Kathrin F., Pennings, Marloes A. M., Cossar, Peter J., Tse, Isabelle L., Kaiser, Markus, Brunsveld, Luc, Ottmann, Christian, Scott, Donald K.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02.03.2025 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/2 14-3-3 protein 14-3-3 Proteins - genetics 14-3-3 Proteins - metabolism 14/1 14/34 14/35 14/63 38/77 42/35 42/44 45/77 45/88 45/90 631/45/612/822 631/92/613 Adhesives Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - chemistry Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Beta cells Carbohydrates Cell death Cytoplasm Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Glucose - metabolism Glucose - toxicity Glues Humanities and Social Sciences Humans Hyperglycemia Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Isoforms Mice multidisciplinary Protein Binding Protein interaction Proteins Science Science (multidisciplinary) Transcription factors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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