Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis

•Cerebral small vessel disease may lead to stroke, dementia, and depression.•We did a systematic review/meta-analysis of studies on these associations.•Strong and consistent associations were found.•In particular for combined MRI features of small vessel disease.•A substantial burden of disease is a...

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Bibliographic Details
Published in:	Neuroscience and biobehavioral reviews Vol. 90; pp. 164 - 173
Main Authors:	Rensma, Sytze P., van Sloten, Thomas T., Launer, Lenore J., Stehouwer, Coen D.A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 01.07.2018
Subjects:	Cerebral atrophy Cerebral small vessel disease Cerebral Small Vessel Diseases - complications Cerebral Small Vessel Diseases - mortality Dementia Dementia - complications Dementia - mortality Depression Depression - mortality Depressive Disorder - complications Depressive Disorder - mortality Humans Lacunes Meta-analysis Microbleeds Mortality Perivascular spaces Risk Stroke Stroke - complications Stroke - mortality Systematic review White matter hyperintensities White matter hyperintensities Stroke Mortality Depression Systematic review Microbleeds Lacunes Perivascular spaces Cerebral atrophy Cerebral small vessel disease Dementia Meta-analysis
ISSN:	0149-7634, 1873-7528, 1873-7528
Online Access:	Get full text
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