Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis

•Cerebral small vessel disease may lead to stroke, dementia, and depression.•We did a systematic review/meta-analysis of studies on these associations.•Strong and consistent associations were found.•In particular for combined MRI features of small vessel disease.•A substantial burden of disease is a...

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Veröffentlicht in:	Neuroscience and biobehavioral reviews Jg. 90; S. 164 - 173
Hauptverfasser:	Rensma, Sytze P., van Sloten, Thomas T., Launer, Lenore J., Stehouwer, Coen D.A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Ltd 01.07.2018
Schlagworte:	Cerebral atrophy Cerebral small vessel disease Cerebral Small Vessel Diseases - complications Cerebral Small Vessel Diseases - mortality Dementia Dementia - complications Dementia - mortality Depression Depression - mortality Depressive Disorder - complications Depressive Disorder - mortality Humans Lacunes Meta-analysis Microbleeds Mortality Perivascular spaces Risk Stroke Stroke - complications Stroke - mortality Systematic review White matter hyperintensities White matter hyperintensities Stroke Mortality Depression Systematic review Microbleeds Lacunes Perivascular spaces Cerebral atrophy Cerebral small vessel disease Dementia Meta-analysis
ISSN:	0149-7634, 1873-7528, 1873-7528
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Abstract	•Cerebral small vessel disease may lead to stroke, dementia, and depression.•We did a systematic review/meta-analysis of studies on these associations.•Strong and consistent associations were found.•In particular for combined MRI features of small vessel disease.•A substantial burden of disease is attributable to small vessel disease. MRI features of cerebral small vessel disease (CSVD), i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. We conducted a systematic review and meta-analysis on the association between these features and incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. For the association with stroke, 36 studies were identified (number of individuals/events [n] = 38,432/4,136), for dementia 28 (n = 16,458/1,709), for depression nine (n = 9,538/1,746), and for mortality 28 (n = 23,031/2,558). Only two studies evaluated perivascular spaces; these results were not pooled. Pooled analyses showed that all other features were associated with all outcomes (hazard ratios ranged 1.22–2.72). Combinations of two features were more strongly associated with stroke than any individual feature. Individual features and combinations of CSVD features are strongly associated with incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. If these associations are causal, the strength of these associations suggests that a substantial burden of disease is attributable to CSVD.
AbstractList	MRI features of cerebral small vessel disease (CSVD), i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. We conducted a systematic review and meta-analysis on the association between these features and incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. For the association with stroke, 36 studies were identified (number of individuals/events [n] = 38,432/4,136), for dementia 28 (n = 16,458/1,709), for depression nine (n = 9,538/1,746), and for mortality 28 (n = 23,031/2,558). Only two studies evaluated perivascular spaces; these results were not pooled. Pooled analyses showed that all other features were associated with all outcomes (hazard ratios ranged 1.22–2.72). Combinations of two features were more strongly associated with stroke than any individual feature. Individual features and combinations of CSVD features are strongly associated with incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. If these associations are causal, the strength of these associations suggests that a substantial burden of disease is attributable to CSVD. MRI features of cerebral small vessel disease (CSVD), i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. We conducted a systematic review and meta-analysis on the association between these features and incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. For the association with stroke, 36 studies were identified (number of individuals/events [n] = 38,432/4,136), for dementia 28 (n = 16,458/1,709), for depression nine (n = 9,538/1,746), and for mortality 28 (n = 23,031/2,558). Only two studies evaluated perivascular spaces; these results were not pooled. Pooled analyses showed that all other features were associated with all outcomes (hazard ratios ranged 1.22-2.72). Combinations of two features were more strongly associated with stroke than any individual feature. Individual features and combinations of CSVD features are strongly associated with incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. If these associations are causal, the strength of these associations suggests that a substantial burden of disease is attributable to CSVD.MRI features of cerebral small vessel disease (CSVD), i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. We conducted a systematic review and meta-analysis on the association between these features and incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. For the association with stroke, 36 studies were identified (number of individuals/events [n] = 38,432/4,136), for dementia 28 (n = 16,458/1,709), for depression nine (n = 9,538/1,746), and for mortality 28 (n = 23,031/2,558). Only two studies evaluated perivascular spaces; these results were not pooled. Pooled analyses showed that all other features were associated with all outcomes (hazard ratios ranged 1.22-2.72). Combinations of two features were more strongly associated with stroke than any individual feature. Individual features and combinations of CSVD features are strongly associated with incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. If these associations are causal, the strength of these associations suggests that a substantial burden of disease is attributable to CSVD. •Cerebral small vessel disease may lead to stroke, dementia, and depression.•We did a systematic review/meta-analysis of studies on these associations.•Strong and consistent associations were found.•In particular for combined MRI features of small vessel disease.•A substantial burden of disease is attributable to small vessel disease. MRI features of cerebral small vessel disease (CSVD), i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. We conducted a systematic review and meta-analysis on the association between these features and incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. For the association with stroke, 36 studies were identified (number of individuals/events [n] = 38,432/4,136), for dementia 28 (n = 16,458/1,709), for depression nine (n = 9,538/1,746), and for mortality 28 (n = 23,031/2,558). Only two studies evaluated perivascular spaces; these results were not pooled. Pooled analyses showed that all other features were associated with all outcomes (hazard ratios ranged 1.22–2.72). Combinations of two features were more strongly associated with stroke than any individual feature. Individual features and combinations of CSVD features are strongly associated with incident ischaemic and haemorrhagic stroke, all-cause dementia and depression, and all-cause mortality. If these associations are causal, the strength of these associations suggests that a substantial burden of disease is attributable to CSVD.
Author	van Sloten, Thomas T. Rensma, Sytze P. Stehouwer, Coen D.A. Launer, Lenore J.
AuthorAffiliation	a CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre+, PO Box 616, 6200 MD, Maastricht, The Netherlands b Department of Internal Medicine, Maastricht University Medical Centre+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands c Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD, USA
AuthorAffiliation_xml	– name: a CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre+, PO Box 616, 6200 MD, Maastricht, The Netherlands – name: b Department of Internal Medicine, Maastricht University Medical Centre+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands – name: c Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD, USA
Author_xml	– sequence: 1 givenname: Sytze P. surname: Rensma fullname: Rensma, Sytze P. email: s.rensma@maastrichtuniversity.nl organization: CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre+, PO Box 616, 6200 MD, Maastricht, The Netherlands – sequence: 2 givenname: Thomas T. surname: van Sloten fullname: van Sloten, Thomas T. email: t.vansloten@maastrichtuniversity.nl organization: CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre+, PO Box 616, 6200 MD, Maastricht, The Netherlands – sequence: 3 givenname: Lenore J. surname: Launer fullname: Launer, Lenore J. email: LaunerL@nia.nih.gov organization: Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Bethesda, MD, USA – sequence: 4 givenname: Coen D.A. surname: Stehouwer fullname: Stehouwer, Coen D.A. email: cda.stehouwer@mumc.nl organization: CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre+, PO Box 616, 6200 MD, Maastricht, The Netherlands
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29656031$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1038/jcbfm.2015.113 10.1212/WNL.0000000000004259 10.1001/jamapsychiatry.2017.0984 10.1016/S0140-6736(10)60903-8 10.1161/STROKEAHA.108.538629 10.1016/j.jstrokecerebrovasdis.2015.08.003 10.1161/STROKEAHA.111.000038 10.1002/sim.1186 10.1161/CIRCULATIONAHA.104.501163 10.1016/S1474-4422(11)70188-0 10.1038/jhh.2013.22 10.2337/dc11-1162 10.1159/000330019 10.1111/j.1532-5415.2007.01233.x 10.1056/NEJMoa1310799 10.1016/S1474-4422(10)70104-6 10.1161/CIRCULATIONAHA.115.016261 10.1177/0271678X16647396 10.1136/bmj.c3666 10.1016/j.jpsychires.2014.05.005 10.1161/01.STR.0000014421.15948.67 10.3389/fnagi.2013.00072 10.1111/j.0006-341X.2000.00455.x 10.1161/STROKEAHA.117.017839 10.1001/jama.283.15.2008 10.1016/S1474-4422(13)70124-8 10.1212/01.WNL.0000140291.86406.D1 10.1177/1747493017751931 10.1016/j.jcjd.2014.11.006 10.1002/gps.2572 10.1177/0271678X15606723 10.1001/archpsyc.1997.01830220033006 10.1001/jamainternmed.2013.13656
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ISSN	0149-7634 1873-7528
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Keywords	White matter hyperintensities Stroke Mortality Depression Systematic review Microbleeds Lacunes Perivascular spaces Cerebral atrophy Cerebral small vessel disease Dementia Meta-analysis
Language	English
License	This is an open access article under the CC BY license. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 These authors contributed equally to the manuscript.
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PublicationTitle	Neuroscience and biobehavioral reviews
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References	Verdecchia, Reboldi, Angeli, Schillaci, Schwartz, Pickering, Imai, Ohkubo, Kario (bib0140) 2005; 45 Wang, Leonards, Sterzer, Ebinger (bib0150) 2014; 56 Huijts, Duits, van Oostenbrugge, Kroon, de Leeuw, Staals (bib0085) 2013; 5 Benjamin, Zeestraten, Lambert, Ster, Williams, Lawrence, Patel, MacKinnon, Barrick, Markus (bib0020) 2016; 36 Alexopoulos, Meyers, Young, Campbell, Silbersweig, Charlson (bib0010) 1997; 54 Barengo, Antikainen, Kastarinen, Laatikainen, Tuomilehto (bib0015) 2013; 27 Booth, Clarke, Ghersi, Moher, Petticrew, Stewart (bib0025) 2011; 377 De Guio, Jouvent, Biessels, Black, Brayne, Chen, Cordonnier, De Leeuw, Dichgans, Doubal, Duering, Dufouil, Duzel, Fazekas, Hachinski, Ikram, Linn, Matthews, Mazoyer, Mok, Norrving, O’Brien, Pantoni, Ropele, Sachdev, Schmidt, Seshadri, Smith, Sposato, Stephan, Swartz, Tzourio, van Buchem, van der Lugt, van Oostenbrugge, Vernooij, Viswanathan, Werring, Wollenweber, Wardlaw, Chabriat (bib0045) 2016; 36 Prasad, Wiryasaputra, Ng, Kandiah (bib0115) 2011; 31 Duval, Tweedie (bib0065) 2000; 56 Ostergaard, Engedal, Moreton, Hansen, Wardlaw, Dalkara, Markus, Muir (bib0105) 2016; 36 Williamson, Launer, Bryan, Coker, Lazar, Gerstein, Murray, Sullivan, Horowitz, Ding, Marcovina, Lovato, Lovato, Margolis, Davatzikos, Barzilay, Ginsberg, Linz, Miller, Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes, I (bib0160) 2014; 174 Akoudad, Portegies, Koudstaal, Hofman, Van Der Lugt, Ikram, Vernooij (bib0005) 2015; 132 Pantoni (bib0110) 2010; 9 Yu, Zhang, Lu, Fang (bib0170) 2015; 39 Debette, Markus (bib0055) 2010; 341 Charidimou, Shams, Romero, Ding, Veltkamp, Horstmann, Eiriksdottir, van Buchem, Gudnason, Himali, Gurol, Viswanathan, Imaizumi, Vernooij, Seshadri, Greenberg, Benavente, Launer, Shoamanesh, International (bib0040) 2018 Wang, Hou, Yang, Lin, Shi, Wang (bib0145) 2015; 24 Launer, Miller, Williamson, Lazar, Gerstein, Murray, Sullivan, Horowitz, Ding, Marcovina, Lovato, Lovato, Margolis, O’Connor, Lipkin, Hirsch, Coker, Maldjian, Sunshine, Truwit, Davatzikos, Bryan, investigators (bib0095) 2011; 10 Higgins, Thompson (bib0080) 2002; 21 Sharp, Aarsland, Day, Sonnesyn, Ballard, Syst (bib0125) 2011; 26 Charidimou, Imaizumi, Moulin, Biffi, Samarasekera, Yakushiji, Peeters, Vandermeeren, Laloux, Baron, Hernandez-Guillamon, Montaner, Casolla, Gregoire, Kang, Kim, Naka, Smith, Viswanathan, Jager, Al-Shahi Salman, Greenberg, Cordonnier, Werring (bib0030) 2017; 89 Charidimou, Kakar, Fox, Werring (bib0035) 2013; 44 Imano, Kitamura, Sato, Kiyama, Ohira, Yamagishi, Noda, Tanigawa, Iso, Shimamoto (bib0090) 2009; 40 Puy, De Guio, Godin, Duering, Dichgans, Chabriat, Jouvent (bib0120) 2017; 48 van Agtmaal, Houben, Pouwer, Stehouwer, Schram (bib0135) 2017 Gregg, Li, Wang, Burrows, Ali, Rolka, Williams, Geiss (bib0075) 2014; 370 Gregg, Cheng, Saydah, Cowie, Garfield, Geiss, Barker (bib0070) 2012; 35 Li, Rhew, Shofer, Kukull, Breitner, Peskind, Bowen, McCormick, Teri, Crane, Larson (bib0100) 2007; 55 Dufouil, Chalmers, Coskun, Besancon, Bousser, Guillon, MacMahon, Mazoyer, Neal, Woodward, Tzourio-Mazoyer, Tzourio, Investigators (bib0060) 2005; 112 Wardlaw, Smith, Biessels, Cordonnier, Fazekas, Frayne, Lindley, O’Brien, Barkhof, Benavente, Black, Brayne, Breteler, Chabriat, Decarli, de Leeuw, Doubal, Duering, Fox, Greenberg, Hachinski, Kilimann, Mok, Oostenbrugge, Pantoni, Speck, Stephan, Teipel, Viswanathan, Werring, Chen, Smith, van Buchem, Norrving, Gorelick, Dichgans (bib0155) 2013; 12 Xu, Qiu, Wahlin, Winblad, Fratiglioni (bib0165) 2004; 63 Stroup, Berlin, Morton, Olkin, Williamson, Rennie, Moher, Becker, Sipe, Thacker (bib0130) 2000; 283 de la Torre (bib0050) 2002; 33 Xu (10.1016/j.neubiorev.2018.04.003_bib0165) 2004; 63 Akoudad (10.1016/j.neubiorev.2018.04.003_bib0005) 2015; 132 Wardlaw (10.1016/j.neubiorev.2018.04.003_bib0155) 2013; 12 Wang (10.1016/j.neubiorev.2018.04.003_bib0145) 2015; 24 Barengo (10.1016/j.neubiorev.2018.04.003_bib0015) 2013; 27 Ostergaard (10.1016/j.neubiorev.2018.04.003_bib0105) 2016; 36 Prasad (10.1016/j.neubiorev.2018.04.003_bib0115) 2011; 31 Pantoni (10.1016/j.neubiorev.2018.04.003_bib0110) 2010; 9 Wang (10.1016/j.neubiorev.2018.04.003_bib0150) 2014; 56 van Agtmaal (10.1016/j.neubiorev.2018.04.003_bib0135) 2017 De Guio (10.1016/j.neubiorev.2018.04.003_bib0045) 2016; 36 Debette (10.1016/j.neubiorev.2018.04.003_bib0055) 2010; 341 Huijts (10.1016/j.neubiorev.2018.04.003_bib0085) 2013; 5 Puy (10.1016/j.neubiorev.2018.04.003_bib0120) 2017; 48 Launer (10.1016/j.neubiorev.2018.04.003_bib0095) 2011; 10 Booth (10.1016/j.neubiorev.2018.04.003_bib0025) 2011; 377 Li (10.1016/j.neubiorev.2018.04.003_bib0100) 2007; 55 Gregg (10.1016/j.neubiorev.2018.04.003_bib0070) 2012; 35 Benjamin (10.1016/j.neubiorev.2018.04.003_bib0020) 2016; 36 Alexopoulos (10.1016/j.neubiorev.2018.04.003_bib0010) 1997; 54 Stroup (10.1016/j.neubiorev.2018.04.003_bib0130) 2000; 283 de la Torre (10.1016/j.neubiorev.2018.04.003_bib0050) 2002; 33 Gregg (10.1016/j.neubiorev.2018.04.003_bib0075) 2014; 370 Duval (10.1016/j.neubiorev.2018.04.003_bib0065) 2000; 56 Verdecchia (10.1016/j.neubiorev.2018.04.003_bib0140) 2005; 45 Williamson (10.1016/j.neubiorev.2018.04.003_bib0160) 2014; 174 Yu (10.1016/j.neubiorev.2018.04.003_bib0170) 2015; 39 Charidimou (10.1016/j.neubiorev.2018.04.003_bib0040) 2018 Dufouil (10.1016/j.neubiorev.2018.04.003_bib0060) 2005; 112 Higgins (10.1016/j.neubiorev.2018.04.003_bib0080) 2002; 21 Charidimou (10.1016/j.neubiorev.2018.04.003_bib0035) 2013; 44 Charidimou (10.1016/j.neubiorev.2018.04.003_bib0030) 2017; 89 Imano (10.1016/j.neubiorev.2018.04.003_bib0090) 2009; 40 Sharp (10.1016/j.neubiorev.2018.04.003_bib0125) 2011; 26
References_xml	– volume: 63 start-page: 1181 year: 2004 end-page: 1186 ident: bib0165 article-title: Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study publication-title: Neurology – volume: 39 start-page: 266 year: 2015 end-page: 272 ident: bib0170 article-title: Depression and risk for diabetes: a meta-analysis publication-title: Can. J. Diabetes – volume: 35 start-page: 1252 year: 2012 end-page: 1257 ident: bib0070 article-title: Trends in death rates among U.S. Adults with and without diabetes between 1997 and 2006: findings from the national health interview survey publication-title: Diabetes Care – volume: 31 start-page: 431 year: 2011 end-page: 434 ident: bib0115 article-title: White matter disease independently predicts progression from mild cognitive impairment to Alzheimer’s disease in a clinic cohort publication-title: Dement Geriatr Cogn. Disord. – volume: 56 start-page: 56 year: 2014 end-page: 64 ident: bib0150 article-title: White matter lesions and depression: a systematic review and meta-analysis publication-title: J. Psychiatr Res. – volume: 36 start-page: 302 year: 2016 end-page: 325 ident: bib0105 article-title: Cerebral small vessel disease: capillary pathways to stroke and cognitive decline publication-title: J. Cereb. Blood Flow. Metab. – volume: 27 start-page: 693 year: 2013 end-page: 697 ident: bib0015 article-title: The effects of control of systolic and diastolic hypertension on cardiovascular and all-cause mortality in a community-based population cohort publication-title: J. Hum. Hypertens. – volume: 370 start-page: 1514 year: 2014 end-page: 1523 ident: bib0075 article-title: Changes in diabetes-related complications in the United States publication-title: N Engl. J. Med. – volume: 24 start-page: 2728 year: 2015 end-page: 2737 ident: bib0145 article-title: Quantity of cerebral microbleeds, antiplatelet therapy, and intracerebral hemorrhage outcomes: a systematic review and meta-analysis publication-title: J. Stroke Cerebrovasc. Dis. – volume: 48 start-page: 2699 year: 2017 end-page: 2703 ident: bib0120 article-title: Cerebral microbleeds and the risk of incident ischemic stroke in CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) publication-title: Stroke – volume: 9 start-page: 689 year: 2010 end-page: 701 ident: bib0110 article-title: Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges publication-title: Lancet Neurol – volume: 44 start-page: 995 year: 2013 end-page: 1001 ident: bib0035 article-title: Cerebral microbleeds and recurrent stroke risk: systematic review and meta-analysis of prospective ischemic stroke and transient ischemic attack cohorts publication-title: Stroke – volume: 283 start-page: 2008 year: 2000 end-page: 2012 ident: bib0130 article-title: Meta-analysis of observational studies in epidemiology: a proposal for reporting. meta-analysis of observational studies in epidemiology (MOOSE) group publication-title: JAMA – volume: 341 start-page: c3666 year: 2010 ident: bib0055 article-title: The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis publication-title: BMJ – volume: 40 start-page: 1571 year: 2009 end-page: 1577 ident: bib0090 article-title: Trends for blood pressure and its contribution to stroke incidence in the middle-aged Japanese population: the circulatory risk in communities study (CIRCS) publication-title: Stroke – year: 2017 ident: bib0135 article-title: Association of microvascular dysfunction with late-life depression: a systematic review and meta-analysis publication-title: JAMA Psychiatry – volume: 33 start-page: 1152 year: 2002 end-page: 1162 ident: bib0050 article-title: Alzheimer disease as a vascular disorder: nosological evidence publication-title: Stroke – volume: 26 start-page: 661 year: 2011 end-page: 669 ident: bib0125 article-title: Hypertension is a potential risk factor for vascular dementia: systematic review publication-title: Int. J. Geriatr Psychiatry – volume: 21 start-page: 1539 year: 2002 end-page: 1558 ident: bib0080 article-title: Quantifying heterogeneity in a meta-analysis publication-title: Stat Med. – year: 2018 ident: bib0040 article-title: Clinical significance of cerebral microbleeds on MRI: a comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1) publication-title: Int. J. Stroke – volume: 56 start-page: 455 year: 2000 end-page: 463 ident: bib0065 article-title: Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis publication-title: Biometrics – volume: 112 start-page: 1644 year: 2005 end-page: 1650 ident: bib0060 article-title: Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: the PROGRESS (Perindopril protection against recurrent stroke study) magnetic resonance imaging substudy publication-title: Circulation – volume: 132 start-page: 509 year: 2015 end-page: 516 ident: bib0005 article-title: Cerebral microbleeds are associated with an increased risk of stroke: the Rotterdam study publication-title: Circulation – volume: 36 start-page: 228 year: 2016 end-page: 240 ident: bib0020 article-title: Progression of MRI markers in cerebral small vessel disease: sample size considerations for clinical trials publication-title: J. Cereb. Blood Flow. Metab. – volume: 54 start-page: 915 year: 1997 end-page: 922 ident: bib0010 article-title: Vascular depression’ hypothesis publication-title: Arch. Gen. Psychiatry – volume: 45 start-page: 203 year: 2005 end-page: 208 ident: bib0140 article-title: Short- and long-term incidence of stroke in white-coat hypertension publication-title: Hyperfine Interactions – volume: 174 start-page: 324 year: 2014 end-page: 333 ident: bib0160 article-title: Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial publication-title: JAMA Intern. Med. – volume: 10 start-page: 969 year: 2011 end-page: 977 ident: bib0095 article-title: Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy publication-title: Lancet Neurol – volume: 12 start-page: 822 year: 2013 end-page: 838 ident: bib0155 article-title: Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration publication-title: Lancet Neurol – volume: 36 start-page: 1319 year: 2016 end-page: 1337 ident: bib0045 article-title: Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease publication-title: J. Cereb. Blood Flow. Metab. – volume: 377 start-page: 108 year: 2011 end-page: 109 ident: bib0025 article-title: An international registry of systematic-review protocols publication-title: Lancet – volume: 5 start-page: 72 year: 2013 ident: bib0085 article-title: Accumulation of MRI markers of cerebral small vessel disease is associated with decreased cognitive function. A study first-ever lacunar stroke hypertensive patients publication-title: Front. Aging Neurosci. – volume: 89 start-page: 820 year: 2017 end-page: 829 ident: bib0030 article-title: Brain hemorrhage recurrence, small vessel disease type, and cerebral microbleeds: a meta-analysis publication-title: Neurology – volume: 55 start-page: 1161 year: 2007 end-page: 1167 ident: bib0100 article-title: Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study publication-title: J. Am. Geriatr Soc. – volume: 36 start-page: 228 year: 2016 ident: 10.1016/j.neubiorev.2018.04.003_bib0020 article-title: Progression of MRI markers in cerebral small vessel disease: sample size considerations for clinical trials publication-title: J. Cereb. Blood Flow. Metab. doi: 10.1038/jcbfm.2015.113 – volume: 89 start-page: 820 year: 2017 ident: 10.1016/j.neubiorev.2018.04.003_bib0030 article-title: Brain hemorrhage recurrence, small vessel disease type, and cerebral microbleeds: a meta-analysis publication-title: Neurology doi: 10.1212/WNL.0000000000004259 – year: 2017 ident: 10.1016/j.neubiorev.2018.04.003_bib0135 article-title: Association of microvascular dysfunction with late-life depression: a systematic review and meta-analysis publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2017.0984 – volume: 377 start-page: 108 year: 2011 ident: 10.1016/j.neubiorev.2018.04.003_bib0025 article-title: An international registry of systematic-review protocols publication-title: Lancet doi: 10.1016/S0140-6736(10)60903-8 – volume: 40 start-page: 1571 year: 2009 ident: 10.1016/j.neubiorev.2018.04.003_bib0090 article-title: Trends for blood pressure and its contribution to stroke incidence in the middle-aged Japanese population: the circulatory risk in communities study (CIRCS) publication-title: Stroke doi: 10.1161/STROKEAHA.108.538629 – volume: 24 start-page: 2728 year: 2015 ident: 10.1016/j.neubiorev.2018.04.003_bib0145 article-title: Quantity of cerebral microbleeds, antiplatelet therapy, and intracerebral hemorrhage outcomes: a systematic review and meta-analysis publication-title: J. Stroke Cerebrovasc. Dis. doi: 10.1016/j.jstrokecerebrovasdis.2015.08.003 – volume: 44 start-page: 995 year: 2013 ident: 10.1016/j.neubiorev.2018.04.003_bib0035 article-title: Cerebral microbleeds and recurrent stroke risk: systematic review and meta-analysis of prospective ischemic stroke and transient ischemic attack cohorts publication-title: Stroke doi: 10.1161/STROKEAHA.111.000038 – volume: 21 start-page: 1539 year: 2002 ident: 10.1016/j.neubiorev.2018.04.003_bib0080 article-title: Quantifying heterogeneity in a meta-analysis publication-title: Stat Med. doi: 10.1002/sim.1186 – volume: 112 start-page: 1644 year: 2005 ident: 10.1016/j.neubiorev.2018.04.003_bib0060 article-title: Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: the PROGRESS (Perindopril protection against recurrent stroke study) magnetic resonance imaging substudy publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.104.501163 – volume: 10 start-page: 969 year: 2011 ident: 10.1016/j.neubiorev.2018.04.003_bib0095 article-title: Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy publication-title: Lancet Neurol doi: 10.1016/S1474-4422(11)70188-0 – volume: 27 start-page: 693 year: 2013 ident: 10.1016/j.neubiorev.2018.04.003_bib0015 article-title: The effects of control of systolic and diastolic hypertension on cardiovascular and all-cause mortality in a community-based population cohort publication-title: J. Hum. Hypertens. doi: 10.1038/jhh.2013.22 – volume: 35 start-page: 1252 year: 2012 ident: 10.1016/j.neubiorev.2018.04.003_bib0070 article-title: Trends in death rates among U.S. Adults with and without diabetes between 1997 and 2006: findings from the national health interview survey publication-title: Diabetes Care doi: 10.2337/dc11-1162 – volume: 31 start-page: 431 year: 2011 ident: 10.1016/j.neubiorev.2018.04.003_bib0115 article-title: White matter disease independently predicts progression from mild cognitive impairment to Alzheimer’s disease in a clinic cohort publication-title: Dement Geriatr Cogn. Disord. doi: 10.1159/000330019 – volume: 55 start-page: 1161 year: 2007 ident: 10.1016/j.neubiorev.2018.04.003_bib0100 article-title: Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study publication-title: J. Am. Geriatr Soc. doi: 10.1111/j.1532-5415.2007.01233.x – volume: 370 start-page: 1514 issue: 1990-2010 year: 2014 ident: 10.1016/j.neubiorev.2018.04.003_bib0075 article-title: Changes in diabetes-related complications in the United States publication-title: N Engl. J. Med. doi: 10.1056/NEJMoa1310799 – volume: 9 start-page: 689 year: 2010 ident: 10.1016/j.neubiorev.2018.04.003_bib0110 article-title: Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges publication-title: Lancet Neurol doi: 10.1016/S1474-4422(10)70104-6 – volume: 132 start-page: 509 year: 2015 ident: 10.1016/j.neubiorev.2018.04.003_bib0005 article-title: Cerebral microbleeds are associated with an increased risk of stroke: the Rotterdam study publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.115.016261 – volume: 36 start-page: 1319 year: 2016 ident: 10.1016/j.neubiorev.2018.04.003_bib0045 article-title: Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease publication-title: J. Cereb. Blood Flow. Metab. doi: 10.1177/0271678X16647396 – volume: 341 start-page: c3666 year: 2010 ident: 10.1016/j.neubiorev.2018.04.003_bib0055 article-title: The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis publication-title: BMJ doi: 10.1136/bmj.c3666 – volume: 56 start-page: 56 year: 2014 ident: 10.1016/j.neubiorev.2018.04.003_bib0150 article-title: White matter lesions and depression: a systematic review and meta-analysis publication-title: J. Psychiatr Res. doi: 10.1016/j.jpsychires.2014.05.005 – volume: 33 start-page: 1152 year: 2002 ident: 10.1016/j.neubiorev.2018.04.003_bib0050 article-title: Alzheimer disease as a vascular disorder: nosological evidence publication-title: Stroke doi: 10.1161/01.STR.0000014421.15948.67 – volume: 5 start-page: 72 year: 2013 ident: 10.1016/j.neubiorev.2018.04.003_bib0085 article-title: Accumulation of MRI markers of cerebral small vessel disease is associated with decreased cognitive function. A study first-ever lacunar stroke hypertensive patients publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2013.00072 – volume: 56 start-page: 455 year: 2000 ident: 10.1016/j.neubiorev.2018.04.003_bib0065 article-title: Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis publication-title: Biometrics doi: 10.1111/j.0006-341X.2000.00455.x – volume: 48 start-page: 2699 year: 2017 ident: 10.1016/j.neubiorev.2018.04.003_bib0120 article-title: Cerebral microbleeds and the risk of incident ischemic stroke in CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) publication-title: Stroke doi: 10.1161/STROKEAHA.117.017839 – volume: 283 start-page: 2008 year: 2000 ident: 10.1016/j.neubiorev.2018.04.003_bib0130 article-title: Meta-analysis of observational studies in epidemiology: a proposal for reporting. meta-analysis of observational studies in epidemiology (MOOSE) group publication-title: JAMA doi: 10.1001/jama.283.15.2008 – volume: 12 start-page: 822 year: 2013 ident: 10.1016/j.neubiorev.2018.04.003_bib0155 article-title: Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration publication-title: Lancet Neurol doi: 10.1016/S1474-4422(13)70124-8 – volume: 63 start-page: 1181 year: 2004 ident: 10.1016/j.neubiorev.2018.04.003_bib0165 article-title: Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study publication-title: Neurology doi: 10.1212/01.WNL.0000140291.86406.D1 – year: 2018 ident: 10.1016/j.neubiorev.2018.04.003_bib0040 article-title: Clinical significance of cerebral microbleeds on MRI: a comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1) publication-title: Int. J. Stroke doi: 10.1177/1747493017751931 – volume: 39 start-page: 266 year: 2015 ident: 10.1016/j.neubiorev.2018.04.003_bib0170 article-title: Depression and risk for diabetes: a meta-analysis publication-title: Can. J. Diabetes doi: 10.1016/j.jcjd.2014.11.006 – volume: 26 start-page: 661 year: 2011 ident: 10.1016/j.neubiorev.2018.04.003_bib0125 article-title: Hypertension is a potential risk factor for vascular dementia: systematic review publication-title: Int. J. Geriatr Psychiatry doi: 10.1002/gps.2572 – volume: 36 start-page: 302 year: 2016 ident: 10.1016/j.neubiorev.2018.04.003_bib0105 article-title: Cerebral small vessel disease: capillary pathways to stroke and cognitive decline publication-title: J. Cereb. Blood Flow. Metab. doi: 10.1177/0271678X15606723 – volume: 54 start-page: 915 year: 1997 ident: 10.1016/j.neubiorev.2018.04.003_bib0010 article-title: Vascular depression’ hypothesis publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.1997.01830220033006 – volume: 174 start-page: 324 year: 2014 ident: 10.1016/j.neubiorev.2018.04.003_bib0160 article-title: Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial publication-title: JAMA Intern. Med. doi: 10.1001/jamainternmed.2013.13656 – volume: 45 start-page: 203 year: 2005 ident: 10.1016/j.neubiorev.2018.04.003_bib0140 article-title: Short- and long-term incidence of stroke in white-coat hypertension publication-title: Hyperfine Interactions
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Snippet	•Cerebral small vessel disease may lead to stroke, dementia, and depression.•We did a systematic review/meta-analysis of studies on these associations.•Strong... MRI features of cerebral small vessel disease (CSVD), i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may...
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SubjectTerms	Cerebral atrophy Cerebral small vessel disease Cerebral Small Vessel Diseases - complications Cerebral Small Vessel Diseases - mortality Dementia Dementia - complications Dementia - mortality Depression Depression - mortality Depressive Disorder - complications Depressive Disorder - mortality Humans Lacunes Meta-analysis Microbleeds Mortality Perivascular spaces Risk Stroke Stroke - complications Stroke - mortality Systematic review White matter hyperintensities
Title	Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis
URI	https://dx.doi.org/10.1016/j.neubiorev.2018.04.003 https://www.ncbi.nlm.nih.gov/pubmed/29656031 https://www.proquest.com/docview/2025807781 https://pubmed.ncbi.nlm.nih.gov/PMC6123527
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