A simple method for developing lysine targeted covalent protein reagents

Peptide-based covalent probes can target shallow protein surfaces not typically addressable using small molecules, yet there is a need for versatile approaches to convert native peptide sequences into covalent binders that can target a broad range of residues. Here we report protein-based thio-metha...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Nature communications Ročník 14; číslo 1; s. 7933 - 16
Hlavní autori:	Gabizon, Ronen, Tivon, Barr, Reddi, Rambabu N., van den Oetelaar, Maxime C. M., Amartely, Hadar, Cossar, Peter J., Ottmann, Christian, London, Nir
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.12.2023 Nature Publishing Group Nature Portfolio
Predmet:	14-3-3 protein 631/92/2783 631/92/611 631/92/96 82/16 82/29 82/58 82/80 82/83 Binders Binding Colicin E9 Covalence Cysteine Cysteine - chemistry Deoxyribonuclease Esters Humanities and Social Sciences Indicators and Reagents Lysates Lysine Lysine - metabolism Methacrylates multidisciplinary Peptides Peptides - chemistry Proteins Reagents Residues Science Science (multidisciplinary) Thermal stability
ISSN:	2041-1723, 2041-1723
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!