The association between urinary lead concentration and the likelihood of kidney stones in US adults: a population-based study

The negative effects of lead exposure on human health have attracted widespread attention. Our present study focused on assessing the relationship between urinary lead levels (ULL) and the risk of kidney stones in US adults. We used data from NHANES 2007–2018 for this cross-sectional study, where pa...

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Vydáno v:Scientific reports Ročník 15; číslo 1; s. 1653 - 9
Hlavní autoři: Liang, Dan, Liu, Chang, Yang, Mei
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 11.01.2025
Nature Publishing Group
Nature Portfolio
Témata:
692/308
692/700
Adult
Aged
Calculi
Clinical trials
Cross-Sectional Studies
Cross-sectional study
Female
Humanities and Social Sciences
Humans
Kidney Calculi - epidemiology
Kidney Calculi - urine
Kidney diseases
Kidney stones
Kidneys
Lead - urine
Lead content
Male
Middle Aged
multidisciplinary
Nephrolithiasis
NHANES
Nutrition Surveys
Pathogenesis
Population studies
Population-based studies
Prevalence
Regression analysis
Risk Factors
Science
Science (multidisciplinary)
United States - epidemiology
Urinary lead
Urine
United States
United States > US
NHANES
Cross-sectional study
Urinary lead
Kidney stones
ISSN:2045-2322, 2045-2322
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Shrnutí:The negative effects of lead exposure on human health have attracted widespread attention. Our present study focused on assessing the relationship between urinary lead levels (ULL) and the risk of kidney stones in US adults. We used data from NHANES 2007–2018 for this cross-sectional study, where participants had complete data on ULL and kidney stones. The correlation between ULL and kidney stones was explored by weighted multiple logistic regression analysis. In addition, we also performed subgroup analysis and interaction tests. A total of 8325 subjects were included, and the prevalence of kidney stones was 9.90%. In the fully adjusted model, we observed a positive association between ULL and the risk of kidney stones (OR:1.07, 95% CI: 1.01–1.14, p = 0.03). Participants in the highest quartile of ULL had a 64% higher risk of kidney stones than those in the lowest quartile of ULL (OR:1.64, 95% CI: 1.05–2.57, p = 0.03). Subgroup analysis and interaction test indicated that the association between ULL and the risk of kidney stones was similar in different population settings. The findings of this study indicate a positive correlation between urine lead concentration and the risk of kidney stones. The potential prognostic value of the urine lead concentration for kidney stone outcomes was another new area investigated in this study. However, further prospective clinical trials are needed to confirm the role of urine lead in the pathogenesis of kidney disease and to validate urine lead as a reliable predictor of kidney stone risk.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-025-86086-9