A whole lifespan mouse multi-tissue DNA methylation clock

Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks, have been developed for humans and extended to several other species. Three currently available versions of mouse DNAm clocks were either created for individual tissues or tuned toward young ages. Here, we const...

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Veröffentlicht in:	eLife Jg. 7
Hauptverfasser:	Meer, Margarita V, Podolskiy, Dmitriy I, Tyshkovskiy, Alexander, Gladyshev, Vadim N
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Sciences Publications Ltd 14.11.2018 eLife Sciences Publications, Ltd
Schlagworte:	Age Age Factors Aging Animals biological age Biomarkers Chromosomes and Gene Expression clock CpG Islands Datasets Datasets as Topic Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA Methylation Epigenesis, Genetic Female Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Gene expression Genomes Hippocampus - chemistry Hippocampus - metabolism Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Life span lifespan Liver Liver - chemistry Liver - metabolism Longevity - genetics Lung - chemistry Lung - metabolism Male Mice Mice, Inbred Strains Mice, Transgenic Myocardium - chemistry Myocardium - metabolism Organ Specificity Rejuvenation - physiology Tools and Resources United States > US mouse biological age lifespan chromosomes DNA methylation aging clock gene expression
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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