Prime editing for precise and highly versatile genome manipulation

Programmable gene-editing tools have transformed the life sciences and have shown potential for the treatment of genetic disease. Among the CRISPR-Cas technologies that can currently make targeted DNA changes in mammalian cells, prime editors offer an unusual combination of versatility, specificity...

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Bibliographic Details

Published in:	Nature reviews. Genetics Vol. 24; no. 3; pp. 161 - 177
Main Authors:	Chen, Peter J, Liu, David R
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.03.2023
Subjects:	Animals CRISPR CRISPR-Cas Systems Deoxyribonucleic acid DNA DNA - genetics DNA Breaks, Double-Stranded DNA damage Gene Editing Genetic disorders Genome Genome editing Genomes Mammalian cells Mammals - genetics
ISSN:	1471-0056, 1471-0064, 1471-0064
Online Access:	Get full text
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