Prime editing for precise and highly versatile genome manipulation

Programmable gene-editing tools have transformed the life sciences and have shown potential for the treatment of genetic disease. Among the CRISPR-Cas technologies that can currently make targeted DNA changes in mammalian cells, prime editors offer an unusual combination of versatility, specificity...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nature reviews. Genetics Jg. 24; H. 3; S. 161 - 177
Hauptverfasser:	Chen, Peter J, Liu, David R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.03.2023
Schlagworte:	Animals CRISPR CRISPR-Cas Systems Deoxyribonucleic acid DNA DNA - genetics DNA Breaks, Double-Stranded DNA damage Gene Editing Genetic disorders Genome Genome editing Genomes Mammalian cells Mammals - genetics
ISSN:	1471-0056, 1471-0064, 1471-0064
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!