Comparison of intraocular pressure fluctuation and glaucoma progression rate between phakic and pseudophakic eyes in pseudoexfoliation glaucoma

The management of patients with concurrent pseudoexfoliation glaucoma (PXG) and cataract is challenging given its worse prognosis compared to other glaucoma types and the increased risk associated with cataract surgery. In this retrospective study, we investigated the long-term outcomes of cataract...

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Vydáno v:Scientific reports Ročník 14; číslo 1; s. 6 - 8
Hlavní autoři: Kang, Edward, Park, Ji-Hye, Yoo, Chungkwon, Kim, Yong Yeon
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 02.01.2024
Nature Publishing Group
Nature Portfolio
Témata:
692/308/409
692/699/3161/3172
Cataract - complications
Cataracts
Exfoliation Syndrome - complications
Exfoliation Syndrome - surgery
Eye
Eye surgery
Glaucoma
Glaucoma - complications
Glaucoma, Open-Angle - surgery
Humanities and Social Sciences
Humans
Intraocular Pressure
multidisciplinary
Multivariate analysis
Retrospective Studies
Science
Science (multidisciplinary)
Surgery
ISSN:2045-2322, 2045-2322
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Shrnutí:The management of patients with concurrent pseudoexfoliation glaucoma (PXG) and cataract is challenging given its worse prognosis compared to other glaucoma types and the increased risk associated with cataract surgery. In this retrospective study, we investigated the long-term outcomes of cataract surgery in patients with PXG. We enrolled patients with PXG who had undergone cataract surgery at least 2 years previously and compared them with mean deviation (MD) matched patients with phakic eyes. The results showed that both groups experienced a decrease in MD, with the group of pseudophakic eyes exhibiting a significantly higher rate of decline (−2.15 ± 2.66 dB/year vs. −0.86 ± 0.95 dB/year; P  = 0.040). Similarly, there was a trend towards more rapid thinning of the retinal nerve fiber layer in the pseudophakic group (−2.92 ± 2.34 μm/year vs. −1.79 ± 1.71 μm/year; P  = 0.074). No significant differences in the intraocular pressure parameters were observed between the two groups. Multivariate analysis revealed that pseudophakic lens status was significantly associated with a faster rate of MD decline in patients with PXG (regression coefficient, −1.391; P  = 0.022). These findings underscore the importance of close monitoring of patients with pseudophakic PXG to effectively manage glaucoma progression.
Bibliografie:ObjectType-Article-1
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-49099-w