Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study

Understanding the associations and potential drivers of long-term disability in Multiple Sclerosis (MS) is of clinical and prognostic value. Previous data have suggested a link between depression and disability accrual in MS. We aimed to determine whether depression in early MS predicts subsequent a...

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Vydáno v:Scientific reports Ročník 13; číslo 1; s. 8227 - 6
Hlavní autoři: Jacobs, Benjamin M., Daruwalla, Cyrus, McKeon, Mollie O., Al-Najjar, Raghda, Simcock-Davies, Andrea, Tuite-Dalton, Katherine, Brown, J. William L., Dobson, Ruth, Rodgers, Jeff, Middleton, Rod
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 24.05.2023
Nature Publishing Group
Nature Portfolio
Témata:
692/308/174
692/617/375/1411/1666
Anxiety
Anxiety - epidemiology
Anxiety Disorders
Autoimmune diseases
Depression - epidemiology
Humanities and Social Sciences
Humans
Mental depression
multidisciplinary
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - epidemiology
Science
Science (multidisciplinary)
United Kingdom - epidemiology
United Kingdom
United Kingdom > UK
ISSN:2045-2322, 2045-2322
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Shrnutí:Understanding the associations and potential drivers of long-term disability in Multiple Sclerosis (MS) is of clinical and prognostic value. Previous data have suggested a link between depression and disability accrual in MS. We aimed to determine whether depression in early MS predicts subsequent accrual of disability. Using data from the UK MS Register, we identified individuals with and without symptoms of depression and anxiety close to disease onset. We used Cox proportional hazards regression to evaluate whether early depressive or anxiety symptoms predict subsequent physical disability worsening, measured using the Expanded Disability Status Scale (EDSS). We analysed data from 862 people with MS of whom 134 (15.5%) reached an EDSS of ≥ 6.0. Early depressive symptoms were associated with an increased risk of reaching an EDSS of 6.0 (HR 2.42, 95% CI 1.49–3.95, p < 0.001), however this effect dissipated when adjusting for baseline EDSS (HR 1.40, 95% CI 0.84–2.32, p = 0.2). These data suggest that early depressive symptoms in MS are associated with subsequent disability accrual, but are likely the result of disability rather than its cause.
Bibliografie:ObjectType-Article-1
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-34545-6