Validation of computational fluid dynamics models for airway deposition with SPECT data of the same population

This study compared computational fluid dynamic (CFD) model predictions on aerosol deposition in six asthmatic patients to the in-vivo results of the same group. Patient-specific ventilation and internal air distribution were prescribed using inspiratory and expiratory CT scans of each patient, acco...

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Vydáno v:	Scientific reports Ročník 14; číslo 1; s. 5492 - 10
Hlavní autoři:	Sadafi, Hosein, Monshi Tousi, Navid, De Backer, Wilfried, De Backer, Jan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 06.03.2024 Nature Publishing Group Nature Portfolio
Témata:	639/166/988 639/705/1042 692/699/1785 Aerosols Air flow Asthma Asthma - diagnostic imaging Boundary conditions Clinical trials Computed tomography Computer applications Fluid dynamics Humanities and Social Sciences Humans Hydrodynamics Larynx multidisciplinary Nose Population studies Respiration Respiratory Aerosols and Droplets Respiratory tract Science Science (multidisciplinary) Single photon emission computed tomography Tomography, Emission-Computed, Single-Photon Turbulence models
ISSN:	2045-2322, 2045-2322
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Shrnutí:	This study compared computational fluid dynamic (CFD) model predictions on aerosol deposition in six asthmatic patients to the in-vivo results of the same group. Patient-specific ventilation and internal air distribution were prescribed using inspiratory and expiratory CT scans of each patient, accounting for individual lobar air flow distribution. Moreover, the significant influence of realistic mouth and throat geometries on regional deposition is demonstrated. The in-vivo data were obtained from single photon emission computed tomography (SPECT) in 6 subjects with mild asthma selected from a database of historical clinical trials. The governing flow and particle tracking equations were solved numerically using a commercial CFD tool, and the modeled deposition results were compared to the SPECT data. Good agreement was found between the CFD model, applying k-ω SST turbulence model, and SPECT in terms of aerosol deposition. The average difference for the lobar deposition obtained from CFD model and SPECT/CT data was 2.1%. The high level of agreement is due to applying patient specific airway geometries and inspiratory/expiratory CT images, anatomical upper airways, and realistic airway trees. The results of this study show that CFD is a powerful tool to simulate patient-specific deposition if correct boundary conditions are applied and can generate similar information obtained with functional imaging tools, such as SPECT.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-024-56033-1