Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality

Mitochondria carry their own circular genome and disruption of the mitochondrial genome is associated with various aging-related diseases. Unlike the nuclear genome, mitochondrial DNA (mtDNA) can be present at 1000 s to 10,000 s copies in somatic cells and variants may exist in a state of heteroplas...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 6113 - 16
Main Authors:	Hong, Yun Soo, Battle, Stephanie L., Shi, Wen, Puiu, Daniela, Pillalamarri, Vamsee, Xie, Jiaqi, Pankratz, Nathan, Lake, Nicole J., Lek, Monkol, Rotter, Jerome I., Rich, Stephen S., Kooperberg, Charles, Reiner, Alex P., Auer, Paul L., Heard-Costa, Nancy, Liu, Chunyu, Lai, Meng, Murabito, Joanne M., Levy, Daniel, Grove, Megan L., Alonso, Alvaro, Gibbs, Richard, Dugan-Perez, Shannon, Gondek, Lukasz P., Guallar, Eliseo, Arking, Dan E.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.09.2023 Nature Publishing Group Nature Portfolio
Subjects:	631/208/721 631/67/1990/283 631/80/642/333 692/308/2056 Age related diseases Biobanks Cancer Deoxyribonucleic acid DNA DNA, Mitochondrial - genetics Genomes Heterogeneity Heteroplasmy Humanities and Social Sciences Humans Leukemia Leukemia - genetics Mitochondria Mitochondria - genetics Mitochondrial DNA Mortality multidisciplinary Mutation Nucleotides Science Science (multidisciplinary) Somatic cells United Kingdom > UK
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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