Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality

Mitochondria carry their own circular genome and disruption of the mitochondrial genome is associated with various aging-related diseases. Unlike the nuclear genome, mitochondrial DNA (mtDNA) can be present at 1000 s to 10,000 s copies in somatic cells and variants may exist in a state of heteroplas...

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Vydáno v:	Nature communications Ročník 14; číslo 1; s. 6113 - 16
Hlavní autoři:	Hong, Yun Soo, Battle, Stephanie L., Shi, Wen, Puiu, Daniela, Pillalamarri, Vamsee, Xie, Jiaqi, Pankratz, Nathan, Lake, Nicole J., Lek, Monkol, Rotter, Jerome I., Rich, Stephen S., Kooperberg, Charles, Reiner, Alex P., Auer, Paul L., Heard-Costa, Nancy, Liu, Chunyu, Lai, Meng, Murabito, Joanne M., Levy, Daniel, Grove, Megan L., Alonso, Alvaro, Gibbs, Richard, Dugan-Perez, Shannon, Gondek, Lukasz P., Guallar, Eliseo, Arking, Dan E.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 30.09.2023 Nature Publishing Group Nature Portfolio
Témata:	631/208/721 631/67/1990/283 631/80/642/333 692/308/2056 Age related diseases Biobanks Cancer Deoxyribonucleic acid DNA DNA, Mitochondrial - genetics Genomes Heterogeneity Heteroplasmy Humanities and Social Sciences Humans Leukemia Leukemia - genetics Mitochondria Mitochondria - genetics Mitochondrial DNA Mortality multidisciplinary Mutation Nucleotides Science Science (multidisciplinary) Somatic cells United Kingdom > UK
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
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