Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline are not understood. Here, we performed quantitative proteomic analysis from skeletal muscle collected from 58 healthy persons aged 20 to 87...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	eLife Ročník 8
Hlavní autori:	Ubaida-Mohien, Ceereena, Lyashkov, Alexey, Gonzalez-Freire, Marta, Tharakan, Ravi, Shardell, Michelle, Moaddel, Ruin, Semba, Richard D, Chia, Chee W, Gorospe, Myriam, Sen, Ranjan, Ferrucci, Luigi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England eLife Sciences Publications Ltd 23.10.2019 eLife Sciences Publications, Ltd
Predmet:	Adaptive immunity Adult Age Aged Aged, 80 and over Aging Aging - pathology Alternative splicing Animal models Biopsy Epidemiology and Global Health Experiments Female Glycolysis Human Biology and Medicine Humans Inflammation Male Mass spectrometry Medical research Middle Aged Mitochondria Mitochondria - pathology Molecular modelling Muscle Cells Muscle strength Muscle, Skeletal - immunology Muscle, Skeletal - pathology Musculoskeletal system Peptides Proteins Proteolysis Proteome - analysis Proteomics Proteostasis Ribonucleic acid Ribosomal proteins RNA Scientific imaging Skeletal muscle spliceosome Spliceosomes - metabolism Tools and Resources Tricarboxylic acid cycle Young Adult United States > US Baltimore Maryland global health human biology epidemiology proteomics mitochondria medicine aging spliceosome proteostasis skeletal muscle human
ISSN:	2050-084X, 2050-084X
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!