Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline are not understood. Here, we performed quantitative proteomic analysis from skeletal muscle collected from 58 healthy persons aged 20 to 87...

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Bibliographic Details
Published in:	eLife Vol. 8
Main Authors:	Ubaida-Mohien, Ceereena, Lyashkov, Alexey, Gonzalez-Freire, Marta, Tharakan, Ravi, Shardell, Michelle, Moaddel, Ruin, Semba, Richard D, Chia, Chee W, Gorospe, Myriam, Sen, Ranjan, Ferrucci, Luigi
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications Ltd 23.10.2019 eLife Sciences Publications, Ltd
Subjects:	Adaptive immunity Adult Age Aged Aged, 80 and over Aging Aging - pathology Alternative splicing Animal models Biopsy Epidemiology and Global Health Experiments Female Glycolysis Human Biology and Medicine Humans Inflammation Male Mass spectrometry Medical research Middle Aged Mitochondria Mitochondria - pathology Molecular modelling Muscle Cells Muscle strength Muscle, Skeletal - immunology Muscle, Skeletal - pathology Musculoskeletal system Peptides Proteins Proteolysis Proteome - analysis Proteomics Proteostasis Ribonucleic acid Ribosomal proteins RNA Scientific imaging Skeletal muscle spliceosome Spliceosomes - metabolism Tools and Resources Tricarboxylic acid cycle Young Adult United States > US Baltimore Maryland global health human biology epidemiology proteomics mitochondria medicine aging spliceosome proteostasis skeletal muscle human
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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