CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry

Most vertebrate and plant RNA and small DNA viruses suppress genomic CpG and UpA dinucleotide frequencies, apparently mimicking host mRNA composition. Artificially increasing CpG/UpA dinucleotides attenuates viruses through an entirely unknown mechanism. Using the echovirus 7 (E7) model in several c...

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Bibliographic Details
Published in:	eLife Vol. 6
Main Authors:	Fros, Jelke Jan, Dietrich, Isabelle, Alshaikhahmed, Kinda, Passchier, Tim Casper, Evans, David John, Simmonds, Peter
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications Ltd 29.09.2017 eLife Sciences Publications, Ltd
Subjects:	Animals Antiviral drugs Antiviral state Bias Cell culture Cell Line codon bias CpG CpG islands dinucleotides DNA methylation DNA viruses enterovirus Enterovirus B, Human - genetics Enterovirus B, Human - physiology Genes Genomes Host-Pathogen Interactions Humans Immunology and Inflammation Infections Influenza Microbiology and Infectious Disease Mimicry mRNA Nucleotides - genetics Plant viruses Replication initiation RNA viruses RNA, Viral - genetics UpA Virions Virus Replication Viruses codon bias enterovirus infectious disease UpA dinucleotides microbiology CpG immunology virus
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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