Widespread chromatin context-dependencies of DNA double-strand break repair proteins

DNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining (MMEJ). The balance of these pathways is dependent on the local chromatin context, but the underlying mechanisms are poorly understood. By combining knockout...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 5334 - 14
Main Authors:	Vergara, Xabier, Manjón, Anna G., de Haas, Marcel, Morris, Ben, Schep, Ruben, Leemans, Christ, Friskes, Anoek, Beijersbergen, Roderick L., Sanders, Mathijs A., Medema, René H., van Steensel, Bas
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 22.06.2024 Nature Publishing Group Nature Portfolio
Subjects:	45/23 45/77 49 49/47 49/56 631/337/1427 631/553/2711 Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - metabolism BRCA2 protein BRCA2 Protein - genetics BRCA2 Protein - metabolism Breast cancer Chromatin Chromatin - genetics Chromatin - metabolism Context Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA damage DNA End-Joining Repair DNA Repair Double-strand break repair Euchromatin Euchromatin - genetics Euchromatin - metabolism Heterochromatin Heterochromatin - genetics Heterochromatin - metabolism Humanities and Social Sciences Humans multidisciplinary Non-homologous end joining Proteins Science Science (multidisciplinary) Synergism Yeast
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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