Single-cell chromatin state analysis with Signac

The recent development of experimental methods for measuring chromatin state at single-cell resolution has created a need for computational tools capable of analyzing these datasets. Here we developed Signac, a comprehensive toolkit for the analysis of single-cell chromatin data. Signac enables an e...

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Bibliographic Details
Published in:	Nature methods Vol. 18; no. 11; pp. 1333 - 1341
Main Authors:	Stuart, Tim, Srivastava, Avi, Madad, Shaista, Lareau, Caleb A, Satija, Rahul
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.11.2021
Subjects:	Bone Marrow Cells - chemistry Bone Marrow Cells - metabolism Chromatin Chromatin - chemistry Chromatin - genetics Chromatin - metabolism Clustering Computational Biology - methods Computer applications Datasets Deoxyribonucleic acid DNA Experimental methods Gene expression Gene Expression Profiling Genotypes Humans Interoperability Leukocytes, Mononuclear - chemistry Leukocytes, Mononuclear - metabolism Measurement methods Mitochondria Mitochondria - genetics Quality control Sequence Analysis, DNA Single-Cell Analysis - methods Software
ISSN:	1548-7091, 1548-7105, 1548-7105
Online Access:	Get full text
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