Comparison of infection and human immune responses of two SARS-CoV-2 strains in a humanized hACE2 NIKO mouse model

The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized hACE2 (adenovirus expressing hACE2) NOD-SCID IL2R...

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Published in:Scientific reports Vol. 13; no. 1; pp. 12484 - 10
Main Authors: Yong, Kylie Su Mei, Anderson, Danielle E., Zheng, Adrian Kang Eng, Liu, Min, Tan, Sue Yee, Tan, Wilson Wei Sheng, Chen, Qingfeng, Wang, Lin-Fa
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.08.2023
Nature Publishing Group
Nature Portfolio
Subjects:
631/250
631/326
Adenoviruses
Animal models
Animals
Antigens
Chemokines
COVID-19
Cytokines
Cytomegalovirus
Disease
Disease Models, Animal
Experimental infection
Experiments
Global economy
Histology
Humanities and Social Sciences
Humans
Immune response
Immune system
Immunology
Infections
Inflammation
Lung
Lung cancer
Mice
Mice, Inbred NOD
Mice, SCID
Mice, Transgenic
multidisciplinary
Mutants
Pandemics
Pathogenesis
Plasmids
Proteins
SARS-CoV-2
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Spleen
Stem cells
Therapeutic applications
ISSN:2045-2322, 2045-2322
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Abstract The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized hACE2 (adenovirus expressing hACE2) NOD-SCID IL2Rγ −/− (NIKO) mouse model and compare infection with ancestral and mutant (SARS-CoV-2-∆382) strains of SARS-CoV-2. Immune cell infiltration, inflammation, lung damage and pro-inflammatory cytokines and chemokines was observed in humanized hACE2 NIKO mice. Humanized hACE2 NIKO mice infected with the ancestral and mutant SARS-CoV-2 strain had lung inflammation and production of pro-inflammatory cytokines and chemokines. This model can aid in examining the pathological basis of SARS-CoV-2 infection in a human immune environment and evaluation of therapeutic interventions.
AbstractList The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized hACE2 (adenovirus expressing hACE2) NOD-SCID IL2Rγ −/− (NIKO) mouse model and compare infection with ancestral and mutant (SARS-CoV-2-∆382) strains of SARS-CoV-2. Immune cell infiltration, inflammation, lung damage and pro-inflammatory cytokines and chemokines was observed in humanized hACE2 NIKO mice. Humanized hACE2 NIKO mice infected with the ancestral and mutant SARS-CoV-2 strain had lung inflammation and production of pro-inflammatory cytokines and chemokines. This model can aid in examining the pathological basis of SARS-CoV-2 infection in a human immune environment and evaluation of therapeutic interventions.
The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized hACE2 (adenovirus expressing hACE2) NOD-SCID IL2Rγ-/- (NIKO) mouse model and compare infection with ancestral and mutant (SARS-CoV-2-∆382) strains of SARS-CoV-2. Immune cell infiltration, inflammation, lung damage and pro-inflammatory cytokines and chemokines was observed in humanized hACE2 NIKO mice. Humanized hACE2 NIKO mice infected with the ancestral and mutant SARS-CoV-2 strain had lung inflammation and production of pro-inflammatory cytokines and chemokines. This model can aid in examining the pathological basis of SARS-CoV-2 infection in a human immune environment and evaluation of therapeutic interventions.The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized hACE2 (adenovirus expressing hACE2) NOD-SCID IL2Rγ-/- (NIKO) mouse model and compare infection with ancestral and mutant (SARS-CoV-2-∆382) strains of SARS-CoV-2. Immune cell infiltration, inflammation, lung damage and pro-inflammatory cytokines and chemokines was observed in humanized hACE2 NIKO mice. Humanized hACE2 NIKO mice infected with the ancestral and mutant SARS-CoV-2 strain had lung inflammation and production of pro-inflammatory cytokines and chemokines. This model can aid in examining the pathological basis of SARS-CoV-2 infection in a human immune environment and evaluation of therapeutic interventions.
Abstract The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized hACE2 (adenovirus expressing hACE2) NOD-SCID IL2Rγ−/− (NIKO) mouse model and compare infection with ancestral and mutant (SARS-CoV-2-∆382) strains of SARS-CoV-2. Immune cell infiltration, inflammation, lung damage and pro-inflammatory cytokines and chemokines was observed in humanized hACE2 NIKO mice. Humanized hACE2 NIKO mice infected with the ancestral and mutant SARS-CoV-2 strain had lung inflammation and production of pro-inflammatory cytokines and chemokines. This model can aid in examining the pathological basis of SARS-CoV-2 infection in a human immune environment and evaluation of therapeutic interventions.
The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized hACE2 (adenovirus expressing hACE2) NOD-SCID IL2Rγ−/− (NIKO) mouse model and compare infection with ancestral and mutant (SARS-CoV-2-∆382) strains of SARS-CoV-2. Immune cell infiltration, inflammation, lung damage and pro-inflammatory cytokines and chemokines was observed in humanized hACE2 NIKO mice. Humanized hACE2 NIKO mice infected with the ancestral and mutant SARS-CoV-2 strain had lung inflammation and production of pro-inflammatory cytokines and chemokines. This model can aid in examining the pathological basis of SARS-CoV-2 infection in a human immune environment and evaluation of therapeutic interventions.
The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized hACE2 (adenovirus expressing hACE2) NOD-SCID IL2Rγ (NIKO) mouse model and compare infection with ancestral and mutant (SARS-CoV-2-∆382) strains of SARS-CoV-2. Immune cell infiltration, inflammation, lung damage and pro-inflammatory cytokines and chemokines was observed in humanized hACE2 NIKO mice. Humanized hACE2 NIKO mice infected with the ancestral and mutant SARS-CoV-2 strain had lung inflammation and production of pro-inflammatory cytokines and chemokines. This model can aid in examining the pathological basis of SARS-CoV-2 infection in a human immune environment and evaluation of therapeutic interventions.
ArticleNumber 12484
Author Tan, Wilson Wei Sheng
Tan, Sue Yee
Anderson, Danielle E.
Chen, Qingfeng
Yong, Kylie Su Mei
Zheng, Adrian Kang Eng
Liu, Min
Wang, Lin-Fa
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  doi: 10.1038/s41586-020-2787-6
– volume: 126
  start-page: 1456
  year: 2020
  ident: 39628_CR9
  publication-title: Circ. Res.
  doi: 10.1161/circresaha.120.317015
– volume: 14
  start-page: e1007298
  year: 2018
  ident: 39628_CR46
  publication-title: PLOS Pathogens
  doi: 10.1371/journal.ppat.1007298
– volume: 3
  start-page: e5
  year: 2007
  ident: 39628_CR17
  publication-title: PLoS Pathogens
  doi: 10.1371/journal.ppat.0030005
– volume: 65
  start-page: 1744
  year: 2016
  ident: 39628_CR35
  publication-title: Gut
  doi: 10.1136/gutjnl-2014-307856
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Snippet The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2...
Abstract The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with...
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SubjectTerms 631/250
631/326
Adenoviruses
Animal models
Animals
Antigens
Chemokines
COVID-19
Cytokines
Cytomegalovirus
Disease
Disease Models, Animal
Experimental infection
Experiments
Global economy
Histology
Humanities and Social Sciences
Humans
Immune response
Immune system
Immunology
Infections
Inflammation
Lung
Lung cancer
Mice
Mice, Inbred NOD
Mice, SCID
Mice, Transgenic
multidisciplinary
Mutants
Pandemics
Pathogenesis
Plasmids
Proteins
SARS-CoV-2
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Spleen
Stem cells
Therapeutic applications
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Title Comparison of infection and human immune responses of two SARS-CoV-2 strains in a humanized hACE2 NIKO mouse model
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