Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance

The gut microbiota is a crucial regulator of anti-tumour immunity during immune checkpoint inhibitor therapy. Several bacteria that promote an anti-tumour response to immune checkpoint inhibitors have been identified in mice 1 – 6 . Moreover, transplantation of faecal specimens from responders can i...

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Bibliographic Details
Published in:	Nature (London) Vol. 617; no. 7960; pp. 377 - 385
Main Authors:	Park, Joon Seok, Gazzaniga, Francesca S., Wu, Meng, Luthens, Amalia K., Gillis, Jacob, Zheng, Wen, LaFleur, Martin W., Johnson, Sarah B., Morad, Golnaz, Park, Elizabeth M., Zhou, Yifan, Watowich, Stephanie S., Wargo, Jennifer A., Freeman, Gordon J., Kasper, Dennis L., Sharpe, Arlene H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.05.2023 Nature Publishing Group
Subjects:	38 38/1 38/35 38/77 631/250/251 631/250/580 64 64/60 82 Animal models Animals Antibiotics Antibodies Bacteria Binding Cancer Cancer immunotherapy Cell Adhesion Molecules, Neuronal Clonal deletion Disease Models, Animal Down-Regulation Drug resistance Drug Resistance, Neoplasm - drug effects Effectiveness Fecal Microbiota Transplantation Feces Germ-Free Life Germfree Humanities and Social Sciences Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immunity Immunology Immunotherapy Inhibitors Intestinal microflora Investigations Lymphatic system Lymphocytes Lymphocytes T Melanoma - immunology Melanoma - microbiology Melanoma - therapy Mice Microbiomes Microbiota Microorganisms multidisciplinary PD-1 protein PD-L1 protein Protein Binding - drug effects Science Science (multidisciplinary) T-Lymphocytes - drug effects T-Lymphocytes - immunology Transplantation Transplants Transplants & implants Tumors
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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