Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer

Ferroptosis, a form of programed cell death, can be promoted by inhibitors of the xCT transporter (erastin) or GPX4 (RSL3). We found that GPX4, but not the xCT transporter, is selectively elevated in luminal breast cancer. Consistent with this observation, the majority of luminal breast cancer cell...

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Bibliographic Details
Published in:	Cell death & disease Vol. 14; no. 8; pp. 532 - 12
Main Authors:	Park, Soon Young, Jeong, Kang Jin, Poire, Alfonso, Zhang, Dong, Tsang, Yiu Huen, Blucher, Aurora S., Mills, Gordon B.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.08.2023 Springer Nature B.V Nature Publishing Group
Subjects:	13/1 13/106 13/2 13/31 13/89 14/19 14/34 14/63 38/79 42/41 45/47 631/154/555 631/80/82 64/60 96/2 Antibodies Apoptosis Biochemistry Biomedical and Life Sciences Breast cancer Cancer therapies Cell Biology Cell Culture Cell death Clinical trials DNA damage Enzymes ErbB-2 protein Ferroptosis Humans Immunology Iron Life Sciences Lipid Peroxidation Lipids MCF-7 Cells Membrane Transport Proteins Neoplasms Phosphorylation Proteins Reactive oxygen species S phase Tumor cell lines
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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