New role of fat-free mass in cancer risk linked with genetic predisposition

Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 indiv...

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Veröffentlicht in:Scientific reports Jg. 14; H. 1; S. 7270 - 12
Hauptverfasser: Harris, Benjamin H. L., Di Giovannantonio, Matteo, Zhang, Ping, Harris, David A., Lord, Simon R., Allen, Naomi E., Maughan, Tim S., Bryant, Richard J., Harris, Adrian L., Bond, Gareth L., Buffa, Francesca M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 27.03.2024
Nature Publishing Group
Nature Portfolio
Schlagworte:
631/67
631/67/1347
631/67/1504
631/67/2324
631/67/589
631/67/68
Alternative splicing
Bats
Biobanks
Body Composition - genetics
Body fat
Body Mass Index
Body measurements
Breast cancer
Clinical trials
Colorectal cancer
Colorectal carcinoma
Electric Impedance
Fat-free
Fat-free body mass
Genetic Predisposition to Disease
Genomes
Genomics
Health risks
Humanities and Social Sciences
Humans
Impedance
Male
multidisciplinary
Neoplasms - etiology
Neoplasms - genetics
Obesity
Oncology
Overweight
Post-menopause
Prostate cancer
Rare resources
Science
Science (multidisciplinary)
ISSN:2045-2322, 2045-2322
Online-Zugang:Volltext
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Zusammenfassung:Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 individuals. Using this dataset, a comprehensive analysis using regression, principal component and genome-wide genetic association, provided multiple levels of evidence that increasing whole body fat (WBFM) and fat-free mass (WBFFM) are both associated with increased post-menopausal breast cancer risk, and colorectal cancer risk in men. WBFM was inversely associated with prostate cancer. We also identified rs615029[T] and rs1485995[G] as associated in independent analyses with both PMBC (p = 1.56E–17 and 1.78E–11) and WBFFM (p = 2.88E–08 and 8.24E–12), highlighting splice variants of the intriguing long non-coding RNA CUPID1 (LINC01488) as a potential link between PMBC risk and fat-free mass.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-54291-7