New role of fat-free mass in cancer risk linked with genetic predisposition

Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 indiv...

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Vydáno v:	Scientific reports Ročník 14; číslo 1; s. 7270 - 12
Hlavní autoři:	Harris, Benjamin H. L., Di Giovannantonio, Matteo, Zhang, Ping, Harris, David A., Lord, Simon R., Allen, Naomi E., Maughan, Tim S., Bryant, Richard J., Harris, Adrian L., Bond, Gareth L., Buffa, Francesca M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 27.03.2024 Nature Publishing Group Nature Portfolio
Témata:	631/67 631/67/1347 631/67/1504 631/67/2324 631/67/589 631/67/68 Alternative splicing Bats Biobanks Body Composition - genetics Body fat Body Mass Index Body measurements Breast cancer Clinical trials Colorectal cancer Colorectal carcinoma Electric Impedance Fat-free Fat-free body mass Genetic Predisposition to Disease Genomes Genomics Health risks Humanities and Social Sciences Humans Impedance Male multidisciplinary Neoplasms - etiology Neoplasms - genetics Obesity Oncology Overweight Post-menopause Prostate cancer Rare resources Science Science (multidisciplinary)
ISSN:	2045-2322, 2045-2322
On-line přístup:	Získat plný text
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Shrnutí:	Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 individuals. Using this dataset, a comprehensive analysis using regression, principal component and genome-wide genetic association, provided multiple levels of evidence that increasing whole body fat (WBFM) and fat-free mass (WBFFM) are both associated with increased post-menopausal breast cancer risk, and colorectal cancer risk in men. WBFM was inversely associated with prostate cancer. We also identified rs615029[T] and rs1485995[G] as associated in independent analyses with both PMBC (p = 1.56E–17 and 1.78E–11) and WBFFM (p = 2.88E–08 and 8.24E–12), highlighting splice variants of the intriguing long non-coding RNA CUPID1 (LINC01488) as a potential link between PMBC risk and fat-free mass.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-024-54291-7