Multi-strain modeling of influenza vaccine effectiveness in older adults and its dependence on antigenic distance

Influenza vaccine effectiveness (VE) varies seasonally due to host, virus and vaccine characteristics. To investigate how antigenic matching and dosage impact VE, we developed a mechanistic knowledge-based mathematical model. Immunization with a split vaccine is modeled for exposure to A/H1N1 or A/H...

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Bibliographic Details
Published in:	Scientific reports Vol. 14; no. 1; pp. 27190 - 18
Main Authors:	Urdy, Séverine, Hanke, Matthias, Toledo, Ana I., Ratto, Nicolas, Jacob, Evgueni, Peyronnet, Emmanuel, Gourlet, Jean-Baptiste, Chaves, Sandra S., Thommes, Edward, Coudeville, Laurent, Boissel, Jean-Pierre, Courcelles, Eulalie, Bruezière, Lara
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.11.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/114/2390 631/114/2397 631/154/436/108 631/250/590 631/553/2700 692/699/255/1578 Aged Aged, 80 and over Antigens, Viral - immunology Cell activation Cross-reactivity Dosage Humanities and Social Sciences Humans Immunization Immunogenicity Immunological memory Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H3N2 Subtype - immunology Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Influenza, Human - virology Mathematical models Models, Theoretical multidisciplinary Older people Science Science (multidisciplinary) Seasonal variations Vaccination Vaccine Efficacy Vaccines Viruses
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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