Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms

Genes act in concert with each other in specific contexts to perform their functions. Determining how these genes influence complex traits requires a mechanistic understanding of expression regulation across different conditions. It has been shown that this insight is critical for developing new the...

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Vydáno v:	Nature communications Ročník 14; číslo 1; s. 5562 - 18
Hlavní autoři:	Pividori, Milton, Lu, Sumei, Li, Binglan, Su, Chun, Johnson, Matthew E., Wei, Wei-Qi, Feng, Qiping, Namjou, Bahram, Kiryluk, Krzysztof, Kullo, Iftikhar J., Luo, Yuan, Sullivan, Blair D., Voight, Benjamin F., Skarke, Carsten, Ritchie, Marylyn D., Grant, Struan F. A., Greene, Casey S.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 09.09.2023 Nature Publishing Group Nature Portfolio
Témata:	631/114 631/208/205 Causality Clustered Regularly Interspaced Short Palindromic Repeats CRISPR Disease Epistasis, Genetic Gene expression Gene mapping Gene Regulatory Networks Genes Humanities and Social Sciences Lipids Modules multidisciplinary Perturbation Representations Science Science (multidisciplinary) Transcriptome Transcriptomes
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
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