A temperature-sensitive metabolic valve and a transcriptional feedback loop drive rapid homeoviscous adaptation in Escherichia coli

All free-living microorganisms homeostatically maintain the fluidity of their membranes by adapting lipid composition to environmental temperatures. Here, we quantify enzymes and metabolic intermediates of the Escherichia coli fatty acid and phospholipid synthesis pathways, to describe how this orga...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 9386 - 13
Main Authors:	Hoogerland, Loles, van den Berg, Stefan Pieter Hendrik, Suo, Yixing, Moriuchi, Yuta W., Zoumaro-Djayoon, Adja, Geurken, Esther, Yang, Flora, Bruggeman, Frank, Burkart, Michael D., Bokinsky, Gregory
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.10.2024 Nature Publishing Group Nature Portfolio
Subjects:	631/326/41/1969 631/553/2711 631/92/1643 631/92/314 82/58 Adaptation Adaptation, Physiological Cell Membrane - metabolism Coliforms Composition E coli Enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fatty acids Fatty Acids - metabolism Feedback Feedback loops Feedback, Physiological Fluidity Gene Expression Regulation, Bacterial Humanities and Social Sciences Intermediates Lipid composition Lipids Mathematical models Membrane Fluidity Membranes Metabolic flux Metabolism Microorganisms multidisciplinary Negative feedback Parameter sensitivity Phospholipids Phospholipids - metabolism Science Science (multidisciplinary) Synthesis Temperature Transcription, Genetic Water baths
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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