The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

Background Previous studies show that antibiotic-mediated (abx) alteration of the gut microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory microglial phenotype in male APPPS1-21 mice. However, the effect of GMB perturbation on astrocyte phenotypes and microglial-a...

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Bibliographic Details
Published in:	Molecular neurodegeneration Vol. 18; no. 1; pp. 45 - 29
Main Authors:	Chandra, Sidhanth, Di Meco, Antonio, Dodiya, Hemraj B., Popovic, Jelena, Cuddy, Leah K., Weigle, Ian Q., Zhang, Xiaoqiong, Sadleir, Katherine, Sisodia, Sangram S., Vassar, Robert
Format:	Journal Article
Language:	English
Published:	London BioMed Central 06.07.2023 Springer Nature B.V BMC
Subjects:	Alzheimer Disease - metabolism Alzheimer's disease Amyloid Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Amyloidosis Amyloidosis - metabolism Animal models Animals Antibiotics Astrocyte Astrocytes Astrocytes - metabolism Bacteria Biomedical and Life Sciences Biomedicine Brain Colony-stimulating factor Complement component C3 Confocal microscopy Digestive system Feces Female Gastrointestinal Microbiome Gene expression Genotype & phenotype Germfree Glial fibrillary acidic protein Gliosis Gliosis - metabolism Gut microbiome Gut microbiota Homeostasis Immunoblotting Immunohistochemistry Inflammation Intestinal microflora Macrophage colony-stimulating factor Male Mice Mice, Transgenic Microbiomes Microbiota Microglia Microglia - metabolism Molecular Medicine Morphology Neurodegeneration Neuroinflammation Neurology Neurosciences Pathogens Pathology Phenotypes Plaque, Amyloid - pathology Recruitment Research Article Senile plaques Neuroinflammation Amyloid Astrocyte Gut microbiome
ISSN:	1750-1326, 1750-1326
Online Access:	Get full text
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