Charge-altering releasable transporters enhance mRNA delivery in vitro and exhibit in vivo tropism

The introduction of more effective and selective mRNA delivery systems is required for the advancement of many emerging biomedical technologies including the development of prophylactic and therapeutic vaccines, immunotherapies for cancer and strategies for genome editing. While polymers and oligome...

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Bibliographic Details
Published in:	Nature communications Vol. 14; no. 1; pp. 6983 - 15
Main Authors:	Li, Zhijian, Amaya, Laura, Pi, Ruoxi, Wang, Sean K., Ranjan, Alok, Waymouth, Robert M., Blish, Catherine A., Chang, Howard Y., Wender, Paul A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.11.2023 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/109 13/21 13/31 140/131 140/58 59 59/5 631/61/54/152 639/638/298/54/152 639/638/455/941 64 64/60 Biomedical materials Cancer vaccines Carts Gene Editing Genome editing Genomes Humanities and Social Sciences Immunotherapy Lipids Lymphocytes Lymphocytes T mRNA multidisciplinary Polymers Protein expression Proteins RNA, Messenger - metabolism Science Science (multidisciplinary) System effectiveness T-Lymphocytes - metabolism Transfection Tropism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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