Type 1 interferon mediates chronic stress-induced neuroinflammation and behavioral deficits via complement component 3-dependent pathway

Chronic stress is a major risk factor in the pathophysiology of many neuropsychiatric disorders. Further, chronic stress conditions can promote neuroinflammation and inflammatory responses in both humans and animal models. Type I interferons (IFN-I) are critical mediators of the inflammatory respons...

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Bibliographic Details
Published in:	Molecular psychiatry Vol. 26; no. 7; pp. 3043 - 3059
Main Authors:	Tripathi, Ashutosh, Whitehead, Carl, Surrao, Katelyn, Pillai, Ananya, Madeshiya, Amit, Li, Yong, Khodadadi, Hesam, Ahmed, Anthony O, Turecki, Gustavo, Baban, Babak, Pillai, Anilkumar
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.07.2021
Subjects:	Animal models Animals Behavior Complement C3 Complement component C3 Gene expression Inflammation Interferon Type I Macrophages Mental disorders Mice Mice, Inbred C57BL Neuroinflammatory Diseases - immunology Prefrontal cortex Risk factors Stress, Psychological Suicide β-Interferon
ISSN:	1359-4184, 1476-5578, 1476-5578
Online Access:	Get full text
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