The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology

In Parkinson’s disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying aSyn pathology are still unclear, but they are hypothesized to involve the autophagy-lysosome pathway (ALP). LRRK2 mutations...

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Bibliographic Details

Published in:	NPJ Parkinson's Disease Vol. 9; no. 1; pp. 44 - 17
Main Authors:	Obergasteiger, Julia, Castonguay, Anne-Marie, Pizzi, Sara, Magnabosco, Stefano, Frapporti, Giulia, Lobbestael, Evy, Baekelandt, Veerle, Hicks, Andrew A., Pramstaller, Peter P., Gravel, Claude, Corti, Corrado, Lévesque, Martin, Volta, Mattia
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.03.2023 Nature Publishing Group Nature Portfolio
Subjects:	631/378/1689/1718 631/378/87 631/80 Biomedical and Life Sciences Biomedicine Kinases Mutation Neurology Neuropathology Neurosciences Parkinson's disease
ISSN:	2373-8057, 2373-8057
Online Access:	Get full text
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