Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology

Diastolic dysfunction is increasingly identified as a key, early onset subclinical condition characterizing cardiopathologies of rising prevalence, including diabetic heart disease and heart failure with preserved ejection fraction (HFpEF). Diastolic dysfunction characterization has important progno...

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Vydané v:Scientific reports Ročník 13; číslo 1; s. 12344 - 11
Hlavní autori: Daniels, L. J., Macindoe, C., Koutsifeli, P., Annandale, M., James, S. L., Watson, L. E., Coffey, S., Raaijmakers, A. J. A., Weeks, K. L., Bell, J. R., Janssens, J. V., Curl, C. L., Delbridge, L. M. D., Mellor, Kimberley M.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 31.07.2023
Nature Publishing Group
Nature Portfolio
Predmet:
692/308/1426
692/308/2778
692/4019/592
692/699/2743/137
692/699/2743/2037
692/699/2743/393
Animal models
Animals
Cardiology
Cardiovascular diseases
Congestive heart failure
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnostic imaging
Echocardiography
Echocardiography - methods
Heart diseases
Heart Failure
Humanities and Social Sciences
Male
Metabolic disorders
Mice
multidisciplinary
Myocardium
Regional analysis
Regional planning
Science
Science (multidisciplinary)
Stroke Volume
Ventricle
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Function, Left
ISSN:2045-2322, 2045-2322
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Popis
Shrnutí:Diastolic dysfunction is increasingly identified as a key, early onset subclinical condition characterizing cardiopathologies of rising prevalence, including diabetic heart disease and heart failure with preserved ejection fraction (HFpEF). Diastolic dysfunction characterization has important prognostic value in management of disease outcomes. Validated tools for in vivo monitoring of diastolic function in rodent models of diabetes are required for progress in pre-clinical cardiology studies. 2D speckle tracking echocardiography has emerged as a powerful tool for evaluating cardiac wall deformation throughout the cardiac cycle. The aim of this study was to examine the applicability of 2D speckle tracking echocardiography for comprehensive global and regional assessment of diastolic function in a pre-clinical murine model of cardio-metabolic disease. Type 2 diabetes (T2D) was induced in C57Bl/6 male mice using a high fat high sugar dietary intervention for 20 weeks. Significant impairment in left ventricle peak diastolic strain rate was evident in longitudinal, radial and circumferential planes in T2D mice. Peak diastolic velocity was similarly impaired in the longitudinal and radial planes. Regional analysis of longitudinal peak diastolic strain rate revealed that the anterior free left ventricular wall is particularly susceptible to T2D-induced diastolic dysfunction. These findings provide a significant advance on characterization of diastolic dysfunction in a pre-clinical mouse model of cardiopathology and offer a comprehensive suite of benchmark values for future pre-clinical cardiology studies.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-39499-3