Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice

Increasing evidence has shown that the NOD-like receptor protein 1 (NLRP1) inflammasome is associated with Aβ generation and deposition, which contributes to neuronal damage and neuronal-inflammation in Alzheimer's disease (AD). However, the specific mechanism of NLRP1 inflammasome in the patho...

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Bibliographic Details
Published in:	Behavioral and brain functions Vol. 19; no. 1; pp. 7 - 19
Main Authors:	Li, Xuewang, Zhang, Han, Yang, Liu, Dong, Xianan, Han, Yuli, Su, Yong, Li, Weiping, Li, Weizu
Format:	Journal Article
Language:	English
Published:	London BioMed Central 13.04.2023 Springer Nature B.V BMC
Subjects:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease AMP-Activated Protein Kinases - pharmacology AMPK/mTOR Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - pharmacology Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid beta-Protein Precursor - pharmacology Amyloid Precursor Protein Secretases - pharmacology Animal cognition Animals APP/PS1 mice Aspartic Acid Endopeptidases - pharmacology Autophagy Behavioral Therapy Biomedical and Life Sciences Biomedicine Brain Caspase-1 Cognitive ability Disease Models, Animal Inflammasomes Inflammasomes - metabolism Inflammasomes - pharmacology Inflammation Medical research Mice Mice, Transgenic Neurodegenerative diseases Neurology Neurons Neurosciences NF-κB protein NLR Proteins NLRP1 inflammasome Peptides Presenilin 1 Proteins Psychiatry Software TOR protein TOR Serine-Threonine Kinases - metabolism TOR Serine-Threonine Kinases - pharmacology Tumor necrosis factor-TNF β-Site APP-cleaving enzyme 1 Hungary China NLRP1 inflammasome AMPK/mTOR APP/PS1 mice Alzheimer's disease Autophagy
ISSN:	1744-9081, 1744-9081
Online Access:	Get full text
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