Pan-cancer multi-omic model of LINE-1 activity reveals locus heterogeneity of retrotransposition efficiency

Somatic mobilization of LINE-1 (L1) has been implicated in cancer etiology. We analyzed a recent TCGA data release comprised of nearly 5000 pan-cancer paired tumor-normal whole-genome sequencing (WGS) samples and ~9000 tumor RNA samples. We developed TotalReCall an improved algorithm and pipeline fo...

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Veröffentlicht in:	Nature communications Jg. 16; H. 1; S. 2049 - 18
Hauptverfasser:	Solovyov, Alexander, Behr, Julie M., Hoyos, David, Banks, Eric, Drong, Alexander W., Thornlow, Bryan, Zhong, Jimmy Z., Garcia-Rivera, Enrique, McKerrow, Wilson, Chu, Chong, Arisdakessian, Cedric, Zaller, Dennis M., Kamihara, Junne, Diao, Liyang, Fromer, Menachem, Greenbaum, Benjamin D.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 28.02.2025 Nature Publishing Group Nature Portfolio
Schlagworte:	45/43 45/91 631/114 631/67 Algorithms Cancer Gene Expression Regulation, Neoplastic Gene sequencing Heterogeneity Humanities and Social Sciences Humans Li-Fraumeni syndrome Li-Fraumeni Syndrome - genetics Loci Long Interspersed Nucleotide Elements - genetics Mathematics multidisciplinary Multiomics Mutation Neoplasms - genetics p53 Protein Retrotransposition Science Science (multidisciplinary) Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Whole Genome Sequencing
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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