Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis

Over 60% of women with endometriosis experience abdominopelvic pain and broader pain manifestations, including chronic back pain, fibromyalgia, chronic fatigue, vulvodynia, and migraine. Although the imbalance of proinflammatory mediators, including the complement component C5a, is associated with e...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 10142 - 15
Main Authors:	Titiz, Mustafa, Landini, Lorenzo, Souza Monteiro de Araujo, Daniel, Marini, Matilde, Seravalli, Viola, Chieca, Martina, Pensieri, Pasquale, Montini, Marco, De Siena, Gaetano, Pasquini, Benedetta, Vannuccini, Silvia, Iannone, Luigi Francesco, Cunha, Thiago M., Brancolini, Giulia, Bellantoni, Elisa, Scuffi, Irene, Mastricci, Alessandra, Tesi, Martina, Di Tommaso, Mariarosaria, Petraglia, Felice, Geppetti, Pierangelo, Nassini, Romina, De Logu, Francesco
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.11.2024 Nature Publishing Group Nature Portfolio
Subjects:	13/109 14/32 14/63 42/44 49/88 631/80/304 692/308/1426 692/308/2778 692/308/575 692/700/565/411 82/51 96/1 96/34 96/95 Adaptor Proteins, Signal Transducing Animals Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Back pain Cell activation Chronic pain Complement C5a - metabolism Complement component C5a Disease Models, Animal Endometriosis Endometriosis - metabolism Endometriosis - pathology Fatigue Female Fibromyalgia Headache Humanities and Social Sciences Humans IL-1β Inflammasomes Inflammasomes - metabolism Interleukin-1beta - metabolism Macrophages Macrophages - metabolism Mice Mice, Inbred C57BL Migraine multidisciplinary Nerves Oxidative Stress Pain Pain - metabolism Pain sensitivity Receptor, Anaphylatoxin C5a - genetics Receptor, Anaphylatoxin C5a - metabolism Receptors Schwann cells Schwann Cells - metabolism Science Science (multidisciplinary) Therapeutic targets TRPA1 Cation Channel - genetics TRPA1 Cation Channel - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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