Association between dietary copper intake and constipation in US adults

Dietary micronutrients are integral to the development and progression of constipation; however, the specific relationship between dietary copper intake and constipation has not been thoroughly investigated. This study aims to examine the correlation between dietary copper intake and constipation am...

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Bibliographic Details
Published in:Scientific reports Vol. 14; no. 1; pp. 19237 - 13
Main Authors: Du, Wenyi, Yan, Chen, Wang, Yinkang, Li, Yunfan, Tian, Zhiqiang, Liu, Yuan, Shen, Wei
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 20.08.2024
Nature Publishing Group
Nature Portfolio
Subjects:
692/4020/1503
692/4020/2741
Adult
Aged
Constipation
Constipation - chemically induced
Constipation - epidemiology
Copper
Copper - administration & dosage
Cross-sectional study
Diet - adverse effects
Dietary copper intake
Dietary intake
Dietary supplements
Female
Humanities and Social Sciences
Humans
Male
Micronutrients
Middle Aged
multidisciplinary
National Health and Nutrition Examination Survey
Nutrition Surveys
Prevalence
Regression analysis
Science
Science (multidisciplinary)
Trace elements
Trace elements (nutrients)
United States - epidemiology
Young Adult
United States
United States > US
Dietary copper intake
Cross-sectional study
National Health and Nutrition Examination Survey
Constipation
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Dietary micronutrients are integral to the development and progression of constipation; however, the specific relationship between dietary copper intake and constipation has not been thoroughly investigated. This study aims to examine the correlation between dietary copper intake and constipation among U.S. adults, thereby offering novel insights and recommendations for the clinical management and prevention of constipation. Bowel health data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2010 were analyzed. Subjects’ dietary information was collected through questionnaire records. Multivariate logistic regression analysis, subgroup analysis, and curve fitting analysis were used to assess the correlation between dietary copper intake and chronic constipation. After adjusting for all possible confounders, each unit increase in dietary copper intake (converted to natural logarithms) was associated with a 20% reduction in the prevalence of constipation (OR = 0.80; 95% CI 0.65–0.98; P  = 0.037). The interaction P -values for all subgroups were greater than 0.05, indicating that the findings were stable and consistent across subgroups. The present study showed a significant negative association between dietary copper intake and chronic constipation in adults. This finding raises clinical and healthcare professionals’ awareness of the impact of dietary trace elements on intestinal health and has important implications for the development of personalized meal plans and rational supplementation of trace copper in patients with constipation.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-70331-8