Fecal microbiota transplantation attenuates Alzheimer’s disease symptoms in APP/PS1 transgenic mice via inhibition of the TLR4-MyD88-NF-κB signaling pathway-mediated inflammation

Alzheimer’s disease (AD) is a prevalent and progressive neurodegenerative disorder that is the leading cause of dementia. The underlying mechanisms of AD have not yet been completely explored. Neuroinflammation, an inflammatory response mediated by certain mediators, has been exhibited to play a cru...

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Bibliographic Details
Published in:	Behavioral and brain functions Vol. 21; no. 1; pp. 2 - 21
Main Authors:	Li, Xiang, Ding, Qingyong, Wan, Xinxin, Wu, Qilong, Ye, Shiqing, Lou, Yongliang
Format:	Journal Article
Language:	English
Published:	London BioMed Central 08.01.2025 Springer Nature B.V BMC
Subjects:	Alzheimer Disease - microbiology Alzheimer Disease - therapy Alzheimer's disease Amyloid beta-Protein Precursor - genetics Animals Behavioral Therapy Biomedical and Life Sciences Biomedicine Brain research Cognitive ability Cytokines Dementia disorders Design of experiments Disease Disease Models, Animal Dysbacteriosis Ethanol Fecal microbiota transplantation Fecal Microbiota Transplantation - methods Fecal microflora Feces Gastrointestinal Microbiome - physiology Gut-brain axis Hypotheses Inflammation Inflammation - metabolism Inflammation - therapy Intestinal microbiota Intestinal microflora Investigations Laboratory animals Male Memory Metabolites Mice Mice, Inbred C57BL Mice, Transgenic Microbiota Microbiota-gut-brain axis Mutation MyD88 protein Myeloid Differentiation Factor 88 - metabolism Neurodegenerative diseases Neurology Neurosciences NF-kappa B - metabolism NF-κB protein Pathogenesis Permeability Presenilin 1 Presenilin-1 - genetics Psychiatry Short-chain fatty acids Signal transduction Signal Transduction - physiology Software TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Transgenic animals Transgenic mice Transplantation Transplants & implants Tumor necrosis factor-TNF Short-chain fatty acids Microbiota-gut-brain axis Inflammation Alzheimer’s disease Fecal microbiota transplantation Intestinal microbiota
ISSN:	1744-9081, 1744-9081
Online Access:	Get full text
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