Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI

Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without accommodating recently-admixed individuals with mosaic continental ancestry backgrounds for different segments of their genomes. Here, we de...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 1016 - 14
Main Authors:	Sun, Quan, Rowland, Bryce T., Chen, Jiawen, Mikhaylova, Anna V., Avery, Christy, Peters, Ulrike, Lundin, Jessica, Matise, Tara, Buyske, Steve, Tao, Ran, Mathias, Rasika A., Reiner, Alexander P., Auer, Paul L., Cox, Nancy J., Kooperberg, Charles, Thornton, Timothy A., Raffield, Laura M., Li, Yun
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.02.2024 Nature Publishing Group Nature Portfolio
Subjects:	45 45/43 631/114/2415 631/208/480 631/208/721 C-reactive protein Genomes Health promotion Humanities and Social Sciences Leukocytes multidisciplinary Polygenic inheritance Risk Science Science (multidisciplinary) Segments
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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