Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study

HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are recognized as distinct entities. There remains uncertainty surrounding the causal effects of smoking and alcohol on the development of these two cancer types. Here we perform multivariable Mendelian randomization (MR) to...

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Published in:	Nature communications Vol. 15; no. 1; pp. 7835 - 9
Main Authors:	Thakral, Abhinav, Lee, John JW, Hou, Tianzhichao, Hueniken, Katrina, Dudding, Tom, Gormley, Mark, Virani, Shama, Olshan, Andrew, Diergaarde, Brenda, Ness, Andrew R., Waterboer, Tim, Smith-Byrne, Karl, Brennan, Paul, Hayes, D. Neil, Sanderson, Eleanor, Brown, M. Catherine, Huang, Sophie, Bratman, Scott V., Spreafico, Anna, De Almeida, John, Davies, Joel C., Bierut, Laura, Macfarlane, Gary J., Lagiou, Pagona, Lagiou, Areti, Polesel, Jerry, Agudo, Antonio, Alemany, Laia, Ahrens, Wolfgang, Healy, Claire M., Conway, David I., Nygard, Mari, Canova, Cristina, Holcatova, Ivana, Richiardi, Lorenzo, Znaor, Ariana, Goldstein, David P., Hung, Rayjean J., Xu, Wei, Liu, Geoffrey, Espin-Garcia, Osvaldo
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07.09.2024 Nature Publishing Group Nature Portfolio
Subjects:	45/43 631/67/1536 631/67/2324 Alcohol Alcohol Drinking - adverse effects Alcohols Cancer Case-Control Studies Female Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - epidemiology Head and Neck Neoplasms - genetics Head and Neck Neoplasms - virology Human papillomavirus Humanities and Social Sciences Humans Male Mendelian Randomization Analysis Middle Aged multidisciplinary Multivariable control Papillomaviridae - genetics Papillomavirus Infections - epidemiology Papillomavirus Infections - virology Polymorphism, Single Nucleotide Randomization Risk Factors Science Science (multidisciplinary) Smoking Smoking - adverse effects Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - epidemiology Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - virology
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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