MUC5B Promoter Polymorphism and Interstitial Lung Abnormalities

Variants in the gene encoding mucin 5B ( MUC5B ) have been associated with interstitial fibrosis. This study shows a relationship between the presence of the associated variants in MUC5B and interstitial lung abnormalities in participants in a Framingham study cohort. Subclinical interstitial lung a...

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Vydané v:	The New England journal of medicine Ročník 368; číslo 23; s. 2192 - 2200
Hlavní autori:	Hunninghake, Gary M, Hatabu, Hiroto, Okajima, Yuka, Gao, Wei, Dupuis, Josée, Latourelle, Jeanne C, Nishino, Mizuki, Araki, Tetsuro, Zazueta, Oscar E, Kurugol, Sila, Ross, James C, San José Estépar, Raúl, Murphy, Elissa, Steele, Mark P, Loyd, James E, Schwarz, Marvin I, Fingerlin, Tasha E, Rosas, Ivan O, Washko, George R, O'Connor, George T, Schwartz, David A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Waltham, MA Massachusetts Medical Society 06.06.2013
Predmet:	Aged Biological and medical sciences Chest Cigarette smoking Computed tomography Cough Female Fibrosis Gene polymorphism General aspects Genotype Humans Longitudinal Studies Lung - diagnostic imaging Lung diseases Lung Diseases, Interstitial - diagnostic imaging Lung Diseases, Interstitial - genetics Lung Diseases, Interstitial - physiopathology Lungs Male Medical sciences Middle Aged Mucin Mucin-5B - genetics Polymorphism, Genetic Respiratory Function Tests Smoking Tomography Tomography, X-Ray Computed Total Lung Capacity Medicine Promoter Genetic variability Lung Genotype Anomaly Interstitial Respiratory system Polymorphism
ISSN:	0028-4793, 1533-4406, 1533-4406
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