Fulminant leptomeningeal disease diagnosed as comutant H3F3A and FGFR diffuse midline glioma
Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR diffuse midline glioma with a clinical presentation of fulminant leptomeningitis. A 22‐year‐old male presented with fatal and fulminant diffuse l...
Gespeichert in:
| Veröffentlicht in: | Annals of clinical and translational neurology Jg. 11; H. 11; S. 3037 - 3041 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
John Wiley & Sons, Inc
01.11.2024
John Wiley and Sons Inc Wiley |
| Schlagworte: | |
| ISSN: | 2328-9503, 2328-9503 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR diffuse midline glioma with a clinical presentation of fulminant leptomeningitis. A 22‐year‐old male presented with fatal and fulminant diffuse leptomeningitis. Next‐generation sequencing of plasma and cerebrospinal circulating tumour DNA revealed diffuse midline gliomas with H3F3A and FGFR mutations. Methylome analysis of meningeal tissue collected during autopsy confirmed the diagnosis. Liquid biopsy plays a crucial role in the diagnosis of diffuse midline gliomas, mainly those with exclusively leptomeningeal presentations. |
|---|---|
| AbstractList | Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR diffuse midline glioma with a clinical presentation of fulminant leptomeningitis. A 22-year-old male presented with fatal and fulminant diffuse leptomeningitis. Next-generation sequencing of plasma and cerebrospinal circulating tumour DNA revealed diffuse midline gliomas with H3F3A and FGFR mutations. Methylome analysis of meningeal tissue collected during autopsy confirmed the diagnosis. Liquid biopsy plays a crucial role in the diagnosis of diffuse midline gliomas, mainly those with exclusively leptomeningeal presentations. Abstract Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR diffuse midline glioma with a clinical presentation of fulminant leptomeningitis. A 22‐year‐old male presented with fatal and fulminant diffuse leptomeningitis. Next‐generation sequencing of plasma and cerebrospinal circulating tumour DNA revealed diffuse midline gliomas with H3F3A and FGFR mutations. Methylome analysis of meningeal tissue collected during autopsy confirmed the diagnosis. Liquid biopsy plays a crucial role in the diagnosis of diffuse midline gliomas, mainly those with exclusively leptomeningeal presentations. Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR diffuse midline glioma with a clinical presentation of fulminant leptomeningitis. A 22-year-old male presented with fatal and fulminant diffuse leptomeningitis. Next-generation sequencing of plasma and cerebrospinal circulating tumour DNA revealed diffuse midline gliomas with H3F3A and FGFR mutations. Methylome analysis of meningeal tissue collected during autopsy confirmed the diagnosis. Liquid biopsy plays a crucial role in the diagnosis of diffuse midline gliomas, mainly those with exclusively leptomeningeal presentations.Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR diffuse midline glioma with a clinical presentation of fulminant leptomeningitis. A 22-year-old male presented with fatal and fulminant diffuse leptomeningitis. Next-generation sequencing of plasma and cerebrospinal circulating tumour DNA revealed diffuse midline gliomas with H3F3A and FGFR mutations. Methylome analysis of meningeal tissue collected during autopsy confirmed the diagnosis. Liquid biopsy plays a crucial role in the diagnosis of diffuse midline gliomas, mainly those with exclusively leptomeningeal presentations. Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR diffuse midline glioma with a clinical presentation of fulminant leptomeningitis. A 22‐year‐old male presented with fatal and fulminant diffuse leptomeningitis. Next‐generation sequencing of plasma and cerebrospinal circulating tumour DNA revealed diffuse midline gliomas with H3F3A and FGFR mutations. Methylome analysis of meningeal tissue collected during autopsy confirmed the diagnosis. Liquid biopsy plays a crucial role in the diagnosis of diffuse midline gliomas, mainly those with exclusively leptomeningeal presentations. |
| Author | Benistant, Larysa Castelain, Vincent Reita, Damien Bender, Laura Schenck, Maleka Cebula, Hélène Lhermitte, Benoît |
| AuthorAffiliation | 3 Medical Reanimation Department University Hospital Strasbourg 1 Avenue Molière Strasbourg France 2 Molecular Biology Department University Hospital Strasbourg 1 Avenue Molière Strasbourg France 4 Neurosurgery Department University Hospital Strasbourg 1 Avenue Molière Strasbourg France 6 Laboratory Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, Faculty of Pharmacy UMR CNRS 7021 Illkirch‐Graffenstaden 67401 France 1 Oncology Department Institut de Cancérologie Strasbourg Europe 17 Avenue Albert Calmette Strasbourg France 5 Pathology Department University Hospital Strasbourg 1 Avenue Molière Strasbourg France |
| AuthorAffiliation_xml | – name: 3 Medical Reanimation Department University Hospital Strasbourg 1 Avenue Molière Strasbourg France – name: 5 Pathology Department University Hospital Strasbourg 1 Avenue Molière Strasbourg France – name: 6 Laboratory Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, Faculty of Pharmacy UMR CNRS 7021 Illkirch‐Graffenstaden 67401 France – name: 1 Oncology Department Institut de Cancérologie Strasbourg Europe 17 Avenue Albert Calmette Strasbourg France – name: 2 Molecular Biology Department University Hospital Strasbourg 1 Avenue Molière Strasbourg France – name: 4 Neurosurgery Department University Hospital Strasbourg 1 Avenue Molière Strasbourg France |
| Author_xml | – sequence: 1 givenname: Larysa surname: Benistant fullname: Benistant, Larysa organization: Institut de Cancérologie Strasbourg Europe – sequence: 2 givenname: Damien surname: Reita fullname: Reita, Damien organization: University Hospital Strasbourg – sequence: 3 givenname: Maleka surname: Schenck fullname: Schenck, Maleka organization: University Hospital Strasbourg – sequence: 4 givenname: Vincent surname: Castelain fullname: Castelain, Vincent organization: University Hospital Strasbourg – sequence: 5 givenname: Hélène surname: Cebula fullname: Cebula, Hélène organization: University Hospital Strasbourg – sequence: 6 givenname: Benoît surname: Lhermitte fullname: Lhermitte, Benoît organization: UMR CNRS 7021 – sequence: 7 givenname: Laura orcidid: 0000-0003-3486-8505 surname: Bender fullname: Bender, Laura email: l.bender@icans.eu organization: Institut de Cancérologie Strasbourg Europe |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39440520$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kl1rFDEUhgep2Fp74w-QAW9E2HryMR-5kmVx2kJREL0TwpnkzJolk6yTmUr_vbOdWlovvDohefJwTvK-zI5CDJRlrxmcMwD-AU0Q5wVnNTzLTrjg9UoVII4erY-zs5R2AMAYL0TFX2THQkkJBYeT7Ecz-d4FDGPuaT_GnoILW0KfW5cIE80VtyEmsjmm3MR-Gg_wpWjEOsdg8-ai-TpDXTfNcO-sd4HyrXexx1fZ8w59orP7epp9bz5921yurr9cXG3W1ytTSAYr04I6TCCQybbtUJpS2tIoXlloDUirKiPbkrrSFEidJKxRqq4qW7CdZKU4za4Wr4240_vB9Tjc6ohO323EYatxGJ3xpLkSjCqsS7IkwYJivOVGAWJRtxLa2fVxce2ntidrKIwD-ifSpyfB_dTbeKMZKypeCTkb3t0bhvhrojTq3iVD3mOgOCUtGFMVlzWIGX37D7qL0xDmt5oprsqiEOow3pvHLT308vcXZ-D9ApghpjRQ94Aw0IeU6ENK9F1KZpgt8G_n6fY_pF5vPovlzh98z70I |
| Cites_doi | 10.1148/radiol.211464 10.1093/noajnl/vdad068 10.1007/s00401-018-1936-6 10.3174/ajnr.A6737 10.1038/nature26000 10.3171/2019.9.FOCUS19699 10.1007/s00401-023-02651-4 10.1007/s11864-019-0689-3 10.1007/s00401-020-02259-y 10.1093/neuonc/noac202 10.1093/neuonc/noab106 10.1093/jnen/nlae018 10.1186/s40478-022-01419-3 10.1200/JCO.2017.76.0611 10.1007/s00401-016-1545-1 10.1002/pbc.26416 |
| ContentType | Journal Article |
| Copyright | 2024 The Author(s). published by Wiley Periodicals LLC on behalf of American Neurological Association. 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2024 The Author(s). published by Wiley Periodicals LLC on behalf of American Neurological Association. – notice: 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. – notice: 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P AAYXX CITATION NPM 3V. 7X7 7XB 88G 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ K9. M0S M2M PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM DOA |
| DOI | 10.1002/acn3.52180 |
| DatabaseName | Wiley Online Library Open Access CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Psychology Database (Alumni) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Psychology Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic CrossRef Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Fulminant Meningitis: A Diffuse Midline Glioma |
| EISSN | 2328-9503 |
| EndPage | 3041 |
| ExternalDocumentID | oai_doaj_org_article_2931e7a86ede40d0912b2c90aa58b40b PMC11572734 39440520 10_1002_acn3_52180 ACN352180 |
| Genre | caseStudy Journal Article Case Reports |
| GroupedDBID | 0R~ 1OC 24P 53G 5VS 7X7 8FI 8FJ AAMMB ABDBF ABUWG ACCMX ACGFS ACUHS ACXQS ADBBV ADKYN ADRAZ ADZMN AEFGJ AFKRA AGXDD AIDQK AIDYY ALMA_UNASSIGNED_HOLDINGS ALUQN AOIJS AVUZU AZQEC BAWUL BCNDV BENPR BPHCQ BVXVI CCPQU DIK DWQXO EBS EJD FYUFA GNUQQ GODZA GROUPED_DOAJ HMCUK HYE IAO IHR INH ITC KQ8 M2M M48 OK1 PHGZM PHGZT PIMPY PQQKQ PROAC PSYQQ PUEGO RPM SUPJJ UKHRP WIN AAYXX AFFHD CITATION ALIPV NPM 3V. 7XB 8FK K9. PJZUB PKEHL PPXIY PQEST PQUKI PRINS Q9U 7X8 5PM M~E |
| ID | FETCH-LOGICAL-c5410-cb0952183a14bbfa4c64d6c927d0bc04d97c4b6ef6c5aef4ea8a49f76b0df4163 |
| IEDL.DBID | BENPR |
| ISICitedReferencesCount | 0 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001340190400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2328-9503 |
| IngestDate | Tue Oct 14 18:32:39 EDT 2025 Tue Nov 04 02:04:55 EST 2025 Sun Nov 09 12:18:56 EST 2025 Sat Nov 29 14:49:09 EST 2025 Mon Jul 21 05:59:31 EDT 2025 Sat Nov 29 02:13:31 EST 2025 Sun Sep 21 06:21:58 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| License | Attribution-NonCommercial-NoDerivs 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5410-cb0952183a14bbfa4c64d6c927d0bc04d97c4b6ef6c5aef4ea8a49f76b0df4163 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Case Study-2 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
| ORCID | 0000-0003-3486-8505 |
| OpenAccessLink | https://www.proquest.com/docview/3129655396?pq-origsite=%requestingapplication% |
| PMID | 39440520 |
| PQID | 3129655396 |
| PQPubID | 2034580 |
| PageCount | 5 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_2931e7a86ede40d0912b2c90aa58b40b pubmedcentral_primary_oai_pubmedcentral_nih_gov_11572734 proquest_miscellaneous_3119724803 proquest_journals_3129655396 pubmed_primary_39440520 crossref_primary_10_1002_acn3_52180 wiley_primary_10_1002_acn3_52180_ACN352180 |
| PublicationCentury | 2000 |
| PublicationDate | November 2024 |
| PublicationDateYYYYMMDD | 2024-11-01 |
| PublicationDate_xml | – month: 11 year: 2024 text: November 2024 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Bognor Regis – name: Hoboken |
| PublicationTitle | Annals of clinical and translational neurology |
| PublicationTitleAlternate | Ann Clin Transl Neurol |
| PublicationYear | 2024 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
| References | 2017; 64 2021; 23 2019; 20 2023; 5 2020; 41 2018; 555 2019; 137 2024; 83 2022; 24 2020; 48 2021; 141 2022; 10 2024; 147 2022; 304 2016; 131 2018; 36 e_1_2_9_11_1 e_1_2_9_10_1 e_1_2_9_13_1 e_1_2_9_12_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 e_1_2_9_3_1 Ostrom QT (e_1_2_9_2_1) 2022; 24 e_1_2_9_9_1 e_1_2_9_15_1 e_1_2_9_14_1 e_1_2_9_17_1 e_1_2_9_16_1 |
| References_xml | – volume: 64 issue: 8 year: 2017 article-title: Rapid and fulminant leptomeningeal spread following radiotherapy in DIPG publication-title: Pediatr Blood Cancer – volume: 141 start-page: 323 issue: 2 year: 2021 end-page: 325 article-title: Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations publication-title: Acta Neuropathol – volume: 24 start-page: v1 issue: suppl. 5 year: 2022 end-page: v95 article-title: CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2015–2019 publication-title: Neuro‐Oncology – volume: 137 start-page: 297 issue: 2 year: 2019 end-page: 306 article-title: Molecular profiling of tumors of the brainstem by sequencing of CSF‐derived circulating tumor DNA publication-title: Acta Neuropathol – volume: 83 start-page: 357 issue: 5 year: 2024 end-page: 364 article-title: Diffuse hemispheric glioma with H3 p.K28M (K27M) mutation: unusual non‐midline presentation of diffuse midline glioma, H3 K27M‐altered? publication-title: J Neuropathol Exp Neurol – volume: 131 start-page: 803 issue: 6 year: 2016 end-page: 820 article-title: The 2016 World Health Organization classification of tumors of the central nervous system: a summary publication-title: Acta Neuropathol – volume: 41 start-page: 2155 issue: 11 year: 2020 end-page: 2159 article-title: Diffuse leptomeningeal glioneuronal tumour of childhood publication-title: AJNR Am J Neuroradiol – volume: 20 start-page: 88 issue: 12 year: 2019 article-title: Current advances and future perspectives of cerebrospinal fluid biopsy in midline brain malignancies publication-title: Curr Treat Options in Oncol – volume: 555 start-page: 469 issue: 7697 year: 2018 end-page: 474 article-title: DNA methylation‐based classification of central nervous system tumours publication-title: Nature – volume: 48 issue: 1 year: 2020 article-title: Liquid biopsy for pediatric diffuse midline glioma: a review of circulating tumor DNA and cerebrospinal fluid tumor DNA publication-title: Neurosurg Focus – volume: 10 start-page: 119 year: 2022 article-title: Disseminated diffuse midline gliomas, H3K27‐altered mimicking diffuse leptomeningeal glioneuronal tumors: a diagnostical challenge! publication-title: Acta Neuropathol Commun – volume: 36 start-page: 951 issue: 10 year: 2018 end-page: 958 article-title: Phase II, open‐label, randomized, multicenter trial (HERBY) of bevacizumab in pediatric patients with newly diagnosed high‐grade glioma publication-title: J Clin Oncol – volume: 304 start-page: 174 issue: 1 year: 2022 end-page: 182 article-title: MRI and molecular characterization of pediatric high‐grade midline thalamic gliomas: the HERBY phase II trial publication-title: Radiology – volume: 23 start-page: 1231 issue: 8 year: 2021 end-page: 1251 article-title: The 2021 WHO classification of tumors of the central nervous system: a summary publication-title: Neuro‐Oncology – volume: 5 issue: 1 year: 2023 article-title: Leptomeningeal disease in histone‐mutant gliomas publication-title: Neuro Oncol Adv – volume: 147 start-page: 2 issue: 1 year: 2024 article-title: A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co‐altered: a clinico‐radiological and histomolecular characterisation publication-title: Acta Neuropathol – ident: e_1_2_9_10_1 doi: 10.1148/radiol.211464 – ident: e_1_2_9_11_1 doi: 10.1093/noajnl/vdad068 – ident: e_1_2_9_5_1 doi: 10.1007/s00401-018-1936-6 – ident: e_1_2_9_14_1 doi: 10.3174/ajnr.A6737 – ident: e_1_2_9_4_1 doi: 10.1038/nature26000 – ident: e_1_2_9_16_1 doi: 10.3171/2019.9.FOCUS19699 – ident: e_1_2_9_6_1 doi: 10.1007/s00401-023-02651-4 – ident: e_1_2_9_17_1 doi: 10.1007/s11864-019-0689-3 – ident: e_1_2_9_13_1 doi: 10.1007/s00401-020-02259-y – volume: 24 start-page: v1 issue: 5 year: 2022 ident: e_1_2_9_2_1 article-title: CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2015–2019 publication-title: Neuro‐Oncology doi: 10.1093/neuonc/noac202 – ident: e_1_2_9_3_1 doi: 10.1093/neuonc/noab106 – ident: e_1_2_9_15_1 doi: 10.1093/jnen/nlae018 – ident: e_1_2_9_8_1 doi: 10.1186/s40478-022-01419-3 – ident: e_1_2_9_9_1 doi: 10.1200/JCO.2017.76.0611 – ident: e_1_2_9_7_1 doi: 10.1007/s00401-016-1545-1 – ident: e_1_2_9_12_1 doi: 10.1002/pbc.26416 |
| SSID | ssj0001125372 |
| Score | 2.2727582 |
| Snippet | Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR... Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR... Abstract Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and... |
| SourceID | doaj pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 3037 |
| SubjectTerms | Autopsies Biopsy Brain cancer Case Study Diagnostic tests DNA methylation Genes Glioma Hydrocephalus Kinases Medical prognosis Meningitis Mutation Patients Pediatrics Plasma Spinal cord Steroids Tumors Young adults |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB6hqkJcEOUZ2iIjOCGFem3HTo7bitALK4RA6gHJ8iuwUputurv8_s446WpXILhwShRPJGcm9nxjj78BeIso1ekoTcmVq0rimSy9C3XpvaxMwJCr4yEXmzCzWX1x0XzeKvVFOWEDPfCguBN0R5NkXK1TTIpHdG_Ci9Bw56raK-5p9kXUsxVM5dUV9NvSiA0fqThxoZfv0VcR_-OWB8pE_X9Cl78nSW6D1-x92kfwcISNbDp09wDupf4x3P80bow_ge8YSg5JLewyXa-IVoHW6_CVcQcGrzmnLkXmlgx_szWVD2bnspVT5vrI2o_tF0blUtYofDWPBD_Zj8v54so9hW_th69n5-VYOKEMlcJ5NXgEToR93ER53zkVtIo6NMJE7gNXsTFBeZ06HSqXOpVc7VTTGe157AihPYO9ftGnF8B08JMG50BjklcojvFVdBjEBWEqgYYs4M2dMu31wI9hByZkYUnlNqu8gFPS80aCOK3zA7S0HS1t_2XpAo7urGTHgba0EvGKrirZ6AJeb5pxiNC-h-vTYk0yVFtN1VwW8Hww6qYndC6YUoEKqHfMvdPV3ZZ-_jPTcBNNEZEDFfAu_xl_-X47PZvJfPfyf2jiEB4IxFbDkcgj2FvdrNMx7Idfq_ny5lUeCbe7XwzG priority: 102 providerName: Directory of Open Access Journals – databaseName: Wiley Online Library Open Access dbid: 24P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ba9RAFD6UKuKL90tqlRF9EmInmclMAr6sxdgXlyIKfRDC3NIutNmyF39_z5lksy6KID4lZM6QuZwz8525fAfgLaJUo7zQKZemSIlnMrXGlam1otAOXa6WuxhsQk-n5dlZdboHHzZ3YXp-iHHBjSwjjtdk4MYuj7akocZ14j1OPiU67LeyTJQUuCGXp9sVFpy7RYzehKgBrbrgYuQnzY-22XdmpEjc_ye0-fuhyV_BbJyN6vv_V48HcG9AoWzSq81D2AvdI7jzZdhnfww_0DPtz8iwy3C9IpYGWv7DLMOGDj7jEb3gmVky_OWaohGzE1GLCTOdZ_Xn-iuj6CtrFL6aeSonO7-cza_ME_hef_p2fJIOcRhSV0gcpp1FHEZQymTS2tZIp6RXrsq159Zx6SvtpFWhVa4woZXBlEZWrVaW-5YA31PY7-ZdeA5MOZtVOKRqHaxEcXTXvEGf0OW6yFEvEniz6YvmuqfbaHpi5byhhmpiQyXwkbpplCCK7PhhvjhvBotrEMdkQZtSBR8k94iLcpu7ihtTlFZym8DhppObwW6XjUD4o4pCVCqB12MyWhxto5guzNckQ6HaZMlFAs96nRhLQteM6WRRAuWOtuwUdTelm11EVm9iPSKuoQTeRXX5S_2byfFUxLeDfxF-AXdzhGT9TcpD2F8t1uEl3HY_V7Pl4lU0nhtVnRp3 priority: 102 providerName: Wiley-Blackwell |
| Title | Fulminant leptomeningeal disease diagnosed as comutant H3F3A and FGFR diffuse midline glioma |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Facn3.52180 https://www.ncbi.nlm.nih.gov/pubmed/39440520 https://www.proquest.com/docview/3129655396 https://www.proquest.com/docview/3119724803 https://pubmed.ncbi.nlm.nih.gov/PMC11572734 https://doaj.org/article/2931e7a86ede40d0912b2c90aa58b40b |
| Volume | 11 |
| WOSCitedRecordID | wos001340190400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: DOA dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: 7X7 dateStart: 20140101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: BENPR dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: M2M dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: PIMPY dateStart: 20140101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVWIB databaseName: Wiley Online Library Free Content customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: WIN dateStart: 20140101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell – providerCode: PRVWIB databaseName: Wiley Online Library Open Access customDbUrl: eissn: 2328-9503 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001125372 issn: 2328-9503 databaseCode: 24P dateStart: 20140101 isFulltext: true titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RLUJceD8CZRUEJ6TQrOPEyQltq4b2sFFUgVgkpMivlJXaZNkHv58ZJ7vtCtQLF-flKI5m7Pk8Hn8D8B5RqkxMJIKQyzggnslASZ0GSkWx0DjlqkPtkk2Iokin06zsHW7LPqxyMya6gdq0mnzkhxEapiSOoyz5NP8VUNYoWl3tU2jswT4xlfEB7B-dFOX5tZcF7Xck2JaXlB1K3UQf0WYRD-QNS-QI-_-FMv8OlrwJYp0Vyh_-b_sfwYMef_rjTmEewx3bPIF7k36F_Sn8wDlpFx3jX9r5ivgZyPGHr_RLOXh0wXnW-HLp47fXlIfYP43yaOzLxvj55_zcp7wra6x8NTOEY_2Ly1l7JZ_B1_zky_Fp0GdgCHTMcYDWChEYgSg54krVkuuEm0RnTJhQ6ZCbTGiuElsnOpa25lamkme1SFRoaoJ6z2HQtI19CX6i1SjDwVQIqzhWx4makTgb1EzEDDXCg3cbaVTzjmij6iiVWUUyq5zMPDgiQW1rEDm2u9EuLqq-r1WIYEZWyDSxxvLQICJiiukslDJOFQ-VBwcbEVV9j11W1_Lx4O32MfY1WkCRjW3XVIeStPE0jDx40WnFtiW0wZhiijxId_Rlp6m7T5rZT8fnTXxHxDLkwQenWrf8fzU-LiJ39ur2n3gN9xnCr27X5AEMVou1fQN39e_VbLkYwh7jJZZiKlyZDvuOM3Q-CSwnbIL3yrNJ-R2vvp0VfwAHHSOS |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9NAEB2VgoAL3wVDgUXABcmts1577QNCoRBStYkQaqUekMx-uURq7ZAPEH-K38jM2kmJQL31wClRvIm98fPsm93Z9wBeIEtVqY1lGAmVhKQzGWplslDrOJEGU64yMt5sQg6H2dFR_nENfi32wlBZ5SIm-kBta0Nz5NsxDkxpksR5-mb8LSTXKFpdXVhoNLDYcz9_YMo2fb37Du_vS8577w92-mHrKhCaRGDQMRpZBRED1RFal0qYVNjU5FzaSJtI2FwaoVNXpiZRrhROZUrkpUx1ZEuiL_i7l-CywEyIrCIGfHA2p4NsIZZ8qYLKt5Wp4i06W7Qy7nl7gH9x2r9LM_-kzH7M69383_6tW3CjZdes2zwOt2HNVXfg6qCtH7gLnzHjbmp_2Ikbz0h9gqY18SvtQhW--tJDZ5maMuzrnFyWWT_uxV2mKst6H3qfGLnKzLHx6cgSS2fHJ6P6VN2Dwwvp2wasV3XlHgBLje7kOFRI6bTA5piGWoW5ruEy4Yj3AJ4v7n4xbmREikYwmheEkcJjJIC3BIxlC5L-9h_Uk-OijSQF8rOOkypLnXUissj3uOYmj5RKMi0iHcDmAhJFG4-mxRkeAni2PIyRhJaHVOXqObUhCzqRRXEA9xsULq-Etk9TxVQA2Qo-Vy519Ug1-urVyknNiTSUAnjloXxO_4vuzjD27x6e34mncK1_MNgv9neHe4_gOkei2ewP3YT12WTuHsMV8302mk6e-AeUwZeLxvhvHsV5eA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3LbtNAFL0qBVXd8H4YCgwCNkgmznjssRcIhRbTqiSqEEhdVDLzchupdUIeIH6Nr-PesZMSgbrrglWieJJ4kjN3zp25cw7AC2SpKrWxDCOhkpB0JkOtTBZqHSfSYMpVRcabTcjBIDs8zA_W4NfiLAyVVS5iog_UdmRojbwT48SUJkmcp52qLYs42Cnejr-F5CBFO60LO40GIvvu5w9M36Zv9nbwv37JefH-8_Zu2DoMhCYRGICMRoZBJEF1hdaVEiYVNjU5lzbSJhI2l0bo1FWpSZSrhFOZEnklUx3ZiqgMfu4VuCpFkpB7Qp_3z9d3kDnEki8VUXlHmTp-Td8WrcyB3irgX_z27zLNP-mzn_-KG__zL3cTrresm_WaYXIL1lx9Gzb6bV3BHTjCTLypCWKnbjwjVQpa7sS3tBtY-OhLEp1lasqw33NyX2a7cRH3mKotKz4Unxi5zcyx8dnQEntnx6fD0Zm6C18upW_3YL0e1e4BsNTobo5TiJROC2yO6alVmAMbLhOO4yCA5wsklONGXqRshKR5SXgpPV4CeEcgWbYgSXD_wmhyXLYRpkTe1nVSZamzTkQWeSDX3OSRUkmmRaQD2FrAo2zj1LQ8x0YAz5aXMcLQtpGq3WhObciaTmRRHMD9BpHLO6Fj1VRJFUC2gtWVW129Ug9PvIo5qTyRtlIArzysL-h_2dsexP7Zw4s78RQ2ENrlx73B_iPY5Mg_m2OjW7A-m8zdY7hmvs-G08kTP1YZfL1siP8GC_yCPg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fulminant+leptomeningeal+disease+diagnosed+as+comutant+H3F3A+and+FGFR+diffuse+midline+glioma&rft.jtitle=Annals+of+clinical+and+translational+neurology&rft.au=Benistant%2C+Larysa&rft.au=Reita%2C+Damien&rft.au=Schenck%2C+Maleka&rft.au=Castelain%2C+Vincent&rft.date=2024-11-01&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.eissn=2328-9503&rft.volume=11&rft.issue=11&rft.spage=3037&rft.epage=3041&rft_id=info:doi/10.1002%2Facn3.52180&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2328-9503&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2328-9503&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2328-9503&client=summon |