Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion

There are currently no pharmacological approaches in fracture healing designed to therapeutically stimulate endochondral ossification. In this study, we test nerve growth factor (NGF) as an understudied therapeutic for fracture repair. We first characterized endogenous expression of Ngf and its rece...

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Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; pp. 22241 - 15
Main Authors:	Rivera, Kevin O., Russo, Fabrizio, Boileau, Ryan M., Tomlinson, Ryan E., Miclau, Theodore, Marcucio, Ralph S., Desai, Tejal A., Bahney, Chelsea S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17.12.2020 Nature Publishing Group Nature Portfolio
Subjects:	631/154/51/2314 631/1647/767/2200 631/443/63 692/308/2778 692/698/1671/1354 692/698/1671/63 Animal models Animals Biomarkers Bone healing Bone mineral density Callus Cancellous bone Cartilage Cartilage - diagnostic imaging Cartilage - drug effects Cartilage - physiology Disease Models, Animal Endochondral bone Explants Fluorescent Antibody Technique Fracture Healing - drug effects Fractures Gene expression Gene Expression Profiling Humanities and Social Sciences Imaging, Three-Dimensional Immunohistochemistry Injections, Intralesional Kinases Mice multidisciplinary Nerve growth factor Nerve Growth Factor - administration & dosage Ossification Osteogenesis - drug effects Platelet-derived growth factor Recombinant Proteins - administration & dosage Science Science (multidisciplinary) SDF-1 protein Tibial Fractures Time Factors Transcription activation TrkA protein Tropomyosin Wnt protein X-Ray Microtomography
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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