Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease

Neuroinflammation is one of the hallmarks of Parkinson’s disease (PD) and may contribute to midbrain dopamine (DA) neuron degeneration. Recent studies link chronic inflammation with failure to resolve early inflammation, a process operated by specialized pro-resolving mediators, including resolvins....

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Published in:	Nature communications Vol. 10; no. 1; pp. 3945 - 19
Main Authors:	Krashia, Paraskevi, Cordella, Alberto, Nobili, Annalisa, La Barbera, Livia, Federici, Mauro, Leuti, Alessandro, Campanelli, Federica, Natale, Giuseppina, Marino, Gioia, Calabrese, Valeria, Vedele, Francescangelo, Ghiglieri, Veronica, Picconi, Barbara, Di Lazzaro, Giulia, Schirinzi, Tommaso, Sancesario, Giulia, Casadei, Nicolas, Riess, Olaf, Bernardini, Sergio, Pisani, Antonio, Calabresi, Paolo, Viscomi, Maria Teresa, Serhan, Charles Nicholas, Chiurchiù, Valerio, D’Amelio, Marcello, Mercuri, Nicola Biagio
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02.09.2019 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/21 13/31 13/51 14 14/19 14/63 631/250/371 631/378/1689/1718 64 64/86 9/30 9/74 alpha-Synuclein - genetics alpha-Synuclein - metabolism Animals Degeneration Disease Models, Animal Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - genetics Docosahexaenoic Acids - metabolism Dopamine Dopamine D1 receptors Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Humanities and Social Sciences Humans Inflammation Inflammation - prevention & control Male Mesencephalon Microglia Microglia - drug effects Microglia - metabolism Movement disorders multidisciplinary Neostriatum Nerve Degeneration - prevention & control Neurodegeneration Neurodegenerative diseases Outflow Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - prevention & control Parkinson's disease Rats Rats, Sprague-Dawley Rats, Transgenic Science Science (multidisciplinary) Substantia nigra Substantia Nigra - drug effects Substantia Nigra - metabolism Synuclein γ-Interferon
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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