Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response

Lung cancer rates are rising globally and non-small cell lung cancer (NSCLC) has a five year survival rate of only 24%. Unfortunately, the development of drugs to treat cancer is severely hampered by the inefficiency of translating pre-clinical studies into clinical benefit. Thus, we sought to apply...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; pp. 5535 - 15
Main Authors:	Roller, Devin G., Hoang, Stephen A., Rawls, Kristopher D., Owen, Katherine A., Simmers, Michael B., Figler, Robert A., Wulfkuhle, Julia D., Petricoin, Emanuel F., Wamhoff, Brian R., Gioeli, Daniel
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.03.2021 Nature Publishing Group Nature Portfolio
Subjects:	631/67 631/67/1612 631/67/327 631/67/70 Drug development Endothelial cells Epidermal growth factor receptors Fibroblasts Humanities and Social Sciences Lung cancer Microvasculature multidisciplinary Non-small cell lung carcinoma Proteomics Science Science (multidisciplinary) Small cell lung carcinoma Survival Tumor cells Tumor microenvironment Tumors
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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