Curcumin as an Antiviral Agent

Curcumin, the primary curcuminoid compound found in turmeric spice, has shown broad activity as an antimicrobial agent, limiting the replication of many different fungi, bacteria and viruses. In this review, we summarize recent studies supporting the development of curcumin and its derivatives as br...

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Veröffentlicht in:Viruses Jg. 12; H. 11; S. 1242
Hauptverfasser: Jennings, Morgan R., Parks, Robin J.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI 31.10.2020
MDPI AG
Schlagworte:
Animals
antiviral
antiviral agents
Antiviral Agents - pharmacology
bacteria
broad-spectrum
Curcuma - chemistry
curcumin
Curcumin - chemistry
Curcumin - pharmacology
DNA Viruses - classification
DNA Viruses - drug effects
fungi
Humans
Mice
phytochemical
Review
RNA Viruses - classification
RNA Viruses - drug effects
turmeric
Virus Diseases - drug therapy
viruses
broad-spectrum
antiviral
curcumin
phytochemical
ISSN:1999-4915, 1999-4915
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Abstract Curcumin, the primary curcuminoid compound found in turmeric spice, has shown broad activity as an antimicrobial agent, limiting the replication of many different fungi, bacteria and viruses. In this review, we summarize recent studies supporting the development of curcumin and its derivatives as broad-spectrum antiviral agents.
AbstractList Curcumin, the primary curcuminoid compound found in turmeric spice, has shown broad activity as an antimicrobial agent, limiting the replication of many different fungi, bacteria and viruses. In this review, we summarize recent studies supporting the development of curcumin and its derivatives as broad-spectrum antiviral agents.
Curcumin, the primary curcuminoid compound found in turmeric spice, has shown broad activity as an antimicrobial agent, limiting the replication of many different fungi, bacteria and viruses. In this review, we summarize recent studies supporting the development of curcumin and its derivatives as broad-spectrum antiviral agents.Curcumin, the primary curcuminoid compound found in turmeric spice, has shown broad activity as an antimicrobial agent, limiting the replication of many different fungi, bacteria and viruses. In this review, we summarize recent studies supporting the development of curcumin and its derivatives as broad-spectrum antiviral agents.
Author Jennings, Morgan R.
Parks, Robin J.
AuthorAffiliation 3 Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1N 6N5, Canada
2 Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada
4 Department of Medicine, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada
1 Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; mojennings@toh.ca
AuthorAffiliation_xml – name: 2 Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada
– name: 4 Department of Medicine, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada
– name: 3 Centre for Neuromuscular Disease, University of Ottawa, Ottawa, ON K1N 6N5, Canada
– name: 1 Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; mojennings@toh.ca
Author_xml – sequence: 1
  givenname: Morgan R.
  surname: Jennings
  fullname: Jennings, Morgan R.
– sequence: 2
  givenname: Robin J.
  surname: Parks
  fullname: Parks, Robin J.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33142686$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.intimp.2017.11.009
10.1002/ptr.6738
10.1093/infdis/140.5.802
10.1016/0006-2952(95)98514-A
10.1136/gutjnl-2012-304299
10.1371/journal.pone.0191617
10.1002/jcp.22691
10.3390/molecules25061397
10.4149/av_2015_03_221
10.1016/j.foodchem.2009.09.011
10.1371/journal.ppat.1006289
10.3390/molecules18055389
10.3390/molecules21101401
10.1016/j.antiviral.2015.11.007
10.1007/s12560-016-9255-3
10.1007/s00705-013-1849-6
10.1016/j.ejps.2009.02.019
10.3389/fvets.2019.00038
10.1021/jm070295s
10.1016/j.ejps.2019.02.019
10.1016/S0968-0896(00)82152-5
10.1016/j.antiviral.2018.12.002
10.1016/j.ijpharm.2008.09.009
10.3389/fmicb.2019.00912
10.1021/am405040z
10.1371/journal.ppat.1000852
10.1371/journal.pone.0124903
10.1128/AAC.01328-07
10.1016/S0042-6822(03)00544-0
10.1189/jlb.0307172
10.1007/s13346-018-0543-3
10.1007/s12272-020-01230-5
10.1099/jgv.0.001466
10.1002/biof.1042
10.1158/0008-5472.CAN-09-2468
10.3390/ijms21010337
10.1186/1476-4598-10-12
10.1016/j.antiviral.2019.04.011
10.3390/v11111019
10.1038/srep27539
10.1111/j.1600-0773.1978.tb02240.x
10.1111/1440-1681.12848
10.1186/s43094-020-00126-x
10.1371/journal.pone.0023388
10.1016/S0731-7085(96)02024-9
10.1128/JVI.74.14.6442-6447.2000
10.1186/s12917-017-1218-x
10.1186/1472-6882-6-10
10.1093/infdis/jir260
10.1016/j.vetmic.2009.12.031
10.1016/j.phrs.2015.03.016
10.1016/j.powtec.2012.12.038
10.1039/C5NR07918G
10.1080/08820139.2017.1371908
10.1111/bph.13621
10.3390/molecules24162930
10.1016/j.fsi.2015.03.042
10.1016/j.antiviral.2017.03.014
10.1111/febs.12503
10.1080/10408398.2015.1077195
10.3390/microorganisms8101524
10.1186/s12985-018-1012-9
10.1056/NEJMoa0904849
10.1046/j.1524-475X.1998.60211.x
10.1007/s13337-020-00598-8
10.3892/or.2015.4258
10.1016/j.bmcl.2005.05.032
10.1099/vir.0.79958-0
10.1021/acs.jmedchem.6b00975
10.1016/j.pdpdt.2015.06.005
10.1039/C7NR06520E
10.1007/s13346-019-00633-2
10.1016/j.apsb.2014.06.006
10.1099/vir.0.057448-0
10.1002/smll.201902641
10.1016/j.jfda.2017.12.006
10.1128/JVI.02836-15
10.2174/1570159X11311040002
10.1016/j.bmc.2004.05.006
10.1016/j.phymed.2020.153317
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Issue 11
Keywords broad-spectrum
antiviral
curcumin
phytochemical
Language English
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References Lin (ref_13) 2019; 15
Metzler (ref_82) 2013; 39
Mirani (ref_46) 2019; 9
Jin (ref_33) 2015; 34
Chen (ref_38) 2009; 366
Xia (ref_64) 2018; 15
Sidhu (ref_4) 1998; 6
Devadas (ref_44) 2010; 87
Celum (ref_71) 2010; 362
ref_55
ref_10
Kunnumakkara (ref_6) 2017; 174
Balasubramanian (ref_8) 2019; 162
Bhullar (ref_37) 2013; 18
ref_15
Ou (ref_54) 2013; 280
Maurya (ref_68) 2020; 31
Nelson (ref_83) 2017; 60
Yang (ref_18) 2017; 9
Randazzo (ref_22) 2016; 8
Wilken (ref_5) 2011; 10
Adams (ref_48) 2004; 12
ref_60
Li (ref_12) 2019; 167
Weidner (ref_16) 2016; 125
Du (ref_25) 2017; 13
Zhu (ref_77) 2010; 144
Sharma (ref_45) 2017; 46
Zhang (ref_41) 2011; 226
Harmache (ref_61) 2014; 95
Praditya (ref_7) 2019; 10
ref_69
Padilla (ref_51) 2014; 159
Ferreira (ref_43) 2011; 204
ref_67
Qin (ref_56) 2014; 4
ref_65
ref_20
Feldman (ref_58) 2000; 74
Sui (ref_31) 1993; 1
Vajragupta (ref_42) 2005; 15
Khatun (ref_63) 2016; 90
ref_62
Kumari (ref_11) 2015; 9
ref_28
ref_27
Parikh (ref_74) 2018; 8
Mounce (ref_14) 2017; 142
Dai (ref_19) 2018; 54
Kocaadam (ref_3) 2017; 57
Ali (ref_26) 2016; 6
Wen (ref_66) 2007; 50
Sametband (ref_59) 2014; 6
ref_72
Yang (ref_32) 2015; 95–96
Berk (ref_80) 1986; 5
Reolon (ref_78) 2019; 131
Osterling (ref_47) 2008; 52
Shamma (ref_75) 2013; 237
ref_34
Nimmerjahn (ref_52) 2004; 85
ref_76
ref_30
Jeong (ref_9) 2015; 45
Mazumder (ref_35) 1995; 49
ref_39
Rajagopal (ref_70) 2020; 6
Park (ref_79) 1979; 140
Blennow (ref_29) 1978; 43
Shaikh (ref_73) 2009; 37
ref_81
Lin (ref_49) 2010; 70
Thompson (ref_57) 2003; 315
Yang (ref_17) 2016; 8
Wu (ref_21) 2015; 12
Richart (ref_24) 2018; 26
Wang (ref_1) 1997; 15
Chen (ref_36) 2010; 119
ref_40
ref_84
Zhu (ref_23) 2015; 59
Lee (ref_2) 2013; 11
Colpitts (ref_50) 2014; 63
Han (ref_53) 2018; 45
References_xml – volume: 54
  start-page: 177
  year: 2018
  ident: ref_19
  article-title: Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2017.11.009
– ident: ref_67
  doi: 10.1002/ptr.6738
– volume: 140
  start-page: 802
  year: 1979
  ident: ref_79
  article-title: Acyclovir in Oral and Ganglionic Herpes Simplex Virus Infections
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/140.5.802
– volume: 49
  start-page: 1165
  year: 1995
  ident: ref_35
  article-title: Inhibition of human immunodeficiency virus type-1 integrase by curcumin
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(95)98514-A
– volume: 5
  start-page: 367
  year: 1986
  ident: ref_80
  article-title: Functions of adenovirus E1A
  publication-title: Cancer Surv.
– volume: 63
  start-page: 1137
  year: 2014
  ident: ref_50
  article-title: Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells
  publication-title: Gut
  doi: 10.1136/gutjnl-2012-304299
– ident: ref_20
  doi: 10.1371/journal.pone.0191617
– volume: 226
  start-page: 3385
  year: 2011
  ident: ref_41
  article-title: HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.22691
– ident: ref_84
  doi: 10.3390/molecules25061397
– volume: 59
  start-page: 221
  year: 2015
  ident: ref_23
  article-title: Curcumin inhibits bovine herpesvirus type 1 entry into MDBK cells
  publication-title: Acta Virol.
  doi: 10.4149/av_2015_03_221
– volume: 119
  start-page: 1346
  year: 2010
  ident: ref_36
  article-title: Curcumin inhibits influenza virus infection and haemagglutination activity
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2009.09.011
– ident: ref_76
  doi: 10.1371/journal.ppat.1006289
– volume: 18
  start-page: 5389
  year: 2013
  ident: ref_37
  article-title: Curcumin and its carbocyclic analogs: Structure-activity in relation to antioxidant and selected biological properties
  publication-title: Molecules
  doi: 10.3390/molecules18055389
– ident: ref_60
  doi: 10.3390/molecules21101401
– volume: 125
  start-page: 51
  year: 2016
  ident: ref_16
  article-title: Curcumin and Boswellia serrata gum resin extract inhibit chikungunya and vesicular stomatitis virus infections in vitro
  publication-title: Antivir. Res
  doi: 10.1016/j.antiviral.2015.11.007
– volume: 8
  start-page: 244
  year: 2016
  ident: ref_22
  article-title: Curcumin-Mediated Photodynamic Inactivation of Norovirus Surrogates
  publication-title: Food Environ. Virol.
  doi: 10.1007/s12560-016-9255-3
– volume: 159
  start-page: 573
  year: 2014
  ident: ref_51
  article-title: Inhibitory effects of curcumin on dengue virus type 2-infected cells in vitro
  publication-title: Arch. Virol.
  doi: 10.1007/s00705-013-1849-6
– volume: 37
  start-page: 223
  year: 2009
  ident: ref_73
  article-title: Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2009.02.019
– ident: ref_62
  doi: 10.3389/fvets.2019.00038
– volume: 9
  start-page: 5051
  year: 2015
  ident: ref_11
  article-title: Inhibition of HIV-1 by curcumin A, a novel curcumin analog
  publication-title: Drug Des. Dev.
– volume: 50
  start-page: 4087
  year: 2007
  ident: ref_66
  article-title: Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus
  publication-title: J. Med. Chem.
  doi: 10.1021/jm070295s
– volume: 131
  start-page: 167
  year: 2019
  ident: ref_78
  article-title: Co-encapsulation of acyclovir and curcumin into microparticles improves the physicochemical characteristics and potentiates in vitro antiviral action: Influence of the polymeric composition
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2019.02.019
– volume: 1
  start-page: 415
  year: 1993
  ident: ref_31
  article-title: Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/S0968-0896(00)82152-5
– volume: 162
  start-page: 71
  year: 2019
  ident: ref_8
  article-title: Inhibition of dengue virus by curcuminoids
  publication-title: Antivir. Res.
  doi: 10.1016/j.antiviral.2018.12.002
– volume: 366
  start-page: 133
  year: 2009
  ident: ref_38
  article-title: An in vitro study of liposomal curcumin: Stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2008.09.009
– volume: 10
  start-page: 912
  year: 2019
  ident: ref_7
  article-title: Anti-infective Properties of the Golden Spice Curcumin
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2019.00912
– volume: 6
  start-page: 1228
  year: 2014
  ident: ref_59
  article-title: Herpes Simplex Virus Type-1 Attachment Inhibition by Functionalized Graphene Oxide
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/am405040z
– ident: ref_40
  doi: 10.1371/journal.ppat.1000852
– ident: ref_10
  doi: 10.1371/journal.pone.0124903
– volume: 52
  start-page: 1768
  year: 2008
  ident: ref_47
  article-title: Development of a Comprehensive Human Immunodeficiency Virus Type 1 Screening Algorithm for Discovery and Preclinical Testing of Topical Microbicides
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.01328-07
– volume: 315
  start-page: 259
  year: 2003
  ident: ref_57
  article-title: Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved
  publication-title: Virology
  doi: 10.1016/S0042-6822(03)00544-0
– volume: 87
  start-page: 915
  year: 2010
  ident: ref_44
  article-title: Lipopolysaccharide suppresses HIV-1 replication in human monocytes by protein kinase C-dependent heme oxygenase-1 induction
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.0307172
– volume: 8
  start-page: 1389
  year: 2018
  ident: ref_74
  article-title: Curcumin-loaded self-nanomicellizing solid dispersion system: Part I: Development, optimization, characterization, and oral bioavailability
  publication-title: Drug Deliv. Transl. Res.
  doi: 10.1007/s13346-018-0543-3
– ident: ref_55
  doi: 10.1007/s12272-020-01230-5
– ident: ref_65
  doi: 10.1099/jgv.0.001466
– volume: 39
  start-page: 14
  year: 2013
  ident: ref_82
  article-title: Curcumin uptake and metabolism
  publication-title: BioFactors
  doi: 10.1002/biof.1042
– volume: 70
  start-page: 2445
  year: 2010
  ident: ref_49
  article-title: Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-2468
– ident: ref_72
  doi: 10.3390/ijms21010337
– volume: 10
  start-page: 12
  year: 2011
  ident: ref_5
  article-title: Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-10-12
– volume: 167
  start-page: 98
  year: 2019
  ident: ref_12
  article-title: Curcumin is an APE1 redox inhibitor and exhibits an antiviral activity against KSHV replication and pathogenesis
  publication-title: Antivir. Res.
  doi: 10.1016/j.antiviral.2019.04.011
– ident: ref_15
  doi: 10.3390/v11111019
– volume: 6
  start-page: 27539
  year: 2016
  ident: ref_26
  article-title: Curcumin inhibits HIV-1 by promoting Tat protein degradation
  publication-title: Sci. Rep.
  doi: 10.1038/srep27539
– volume: 43
  start-page: 86
  year: 1978
  ident: ref_29
  article-title: A study on the fate of curcumin in the rat
  publication-title: Acta Pharmacol. Toxicol.
  doi: 10.1111/j.1600-0773.1978.tb02240.x
– ident: ref_28
– volume: 45
  start-page: 84
  year: 2018
  ident: ref_53
  article-title: Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production
  publication-title: Clin. Exp. Pharmacol. Physiol.
  doi: 10.1111/1440-1681.12848
– ident: ref_30
– volume: 6
  start-page: 104
  year: 2020
  ident: ref_70
  article-title: Activity of phytochemical constituents of Curcuma longa (turmeric) and Andrographis paniculata against coronavirus (COVID-19): An in silico approach
  publication-title: Future J. Pharm. Sci.
  doi: 10.1186/s43094-020-00126-x
– ident: ref_39
  doi: 10.1371/journal.pone.0023388
– volume: 15
  start-page: 1867
  year: 1997
  ident: ref_1
  article-title: Stability of curcumin in buffer solutions and characterization of its degradation products
  publication-title: J. Pharm. Biomed. Anal.
  doi: 10.1016/S0731-7085(96)02024-9
– volume: 74
  start-page: 6442
  year: 2000
  ident: ref_58
  article-title: The fusion glycoprotein of human respiratory syncytial virus facilitates virus attachment and infectivity via an interaction with cellular heparan sulfate
  publication-title: J. Virol.
  doi: 10.1128/JVI.74.14.6442-6447.2000
– volume: 13
  start-page: 298
  year: 2017
  ident: ref_25
  article-title: Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection
  publication-title: BMC Vet. Res.
  doi: 10.1186/s12917-017-1218-x
– ident: ref_34
  doi: 10.1186/1472-6882-6-10
– volume: 204
  start-page: 299
  year: 2011
  ident: ref_43
  article-title: Endometrial epithelial cell responses to coinfecting viral and bacterial pathogens in the genital tract can activate the HIV-1 LTR in an NF{kappa}B-and AP-1-dependent manner
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jir260
– volume: 144
  start-page: 51
  year: 2010
  ident: ref_77
  article-title: Critical role of cholesterol in bovine herpesvirus type 1 infection of MDBK cells
  publication-title: Vet. Microbiol.
  doi: 10.1016/j.vetmic.2009.12.031
– volume: 95–96
  start-page: 71
  year: 2015
  ident: ref_32
  article-title: Oral curcumin has anti-arthritic efficacy through somatostatin generation via cAMP/PKA and Ca2+/CaMKII signaling pathways in the small intestine
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2015.03.016
– volume: 237
  start-page: 406
  year: 2013
  ident: ref_75
  article-title: Soluplus®: A novel polymeric solubilizer for optimization of Carvedilol solid dispersions: Formulation design and effect of method of preparation
  publication-title: Powder Technol.
  doi: 10.1016/j.powtec.2012.12.038
– volume: 8
  start-page: 3040
  year: 2016
  ident: ref_17
  article-title: Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection
  publication-title: Nanoscale
  doi: 10.1039/C5NR07918G
– volume: 46
  start-page: 833
  year: 2017
  ident: ref_45
  article-title: Immunomodulatory activities of curcumin-stabilized silver nanoparticles: Efficacy as an antiretroviral therapeutic
  publication-title: Immunol. Investig.
  doi: 10.1080/08820139.2017.1371908
– volume: 174
  start-page: 1325
  year: 2017
  ident: ref_6
  article-title: Curcumin, the golden nutraceutical: Multitargeting for multiple chronic diseases
  publication-title: Br. J. Pharm.
  doi: 10.1111/bph.13621
– ident: ref_27
  doi: 10.3390/molecules24162930
– volume: 45
  start-page: 184
  year: 2015
  ident: ref_9
  article-title: Identification of regulators of the early stage of viral hemorrhagic septicemia virus infection during curcumin treatment
  publication-title: Fish Shellfish Immunol.
  doi: 10.1016/j.fsi.2015.03.042
– volume: 142
  start-page: 148
  year: 2017
  ident: ref_14
  article-title: Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding
  publication-title: Antivir. Res
  doi: 10.1016/j.antiviral.2017.03.014
– volume: 280
  start-page: 5829
  year: 2013
  ident: ref_54
  article-title: Structure-activity relationship analysis of curcumin analogues on anti-influenza virus activity
  publication-title: FEBS J.
  doi: 10.1111/febs.12503
– volume: 57
  start-page: 2889
  year: 2017
  ident: ref_3
  article-title: Curcumin, an active component of turmeric (Curcuma longa), and its effects on health
  publication-title: Crit. Rev. Food Sci. Nutr.
  doi: 10.1080/10408398.2015.1077195
– ident: ref_81
  doi: 10.3390/microorganisms8101524
– volume: 15
  start-page: 102
  year: 2018
  ident: ref_64
  article-title: Impact of TGEV infection on the pig small intestine
  publication-title: Virol. J.
  doi: 10.1186/s12985-018-1012-9
– volume: 362
  start-page: 427
  year: 2010
  ident: ref_71
  article-title: Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0904849
– volume: 6
  start-page: 167
  year: 1998
  ident: ref_4
  article-title: Enhancement of wound healing by curcumin in animals
  publication-title: Wound Repair Regen.
  doi: 10.1046/j.1524-475X.1998.60211.x
– volume: 31
  start-page: 179
  year: 2020
  ident: ref_68
  article-title: Structure-based drug designing for potential antiviral activity of selected natural products from Ayurveda against SARS-CoV-2 spike glycoprotein and its cellular receptor
  publication-title: Virusdisease
  doi: 10.1007/s13337-020-00598-8
– volume: 34
  start-page: 2782
  year: 2015
  ident: ref_33
  article-title: Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2015.4258
– volume: 15
  start-page: 3364
  year: 2005
  ident: ref_42
  article-title: Active site binding modes of curcumin in HIV-1 protease and integrase
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/j.bmcl.2005.05.032
– volume: 85
  start-page: 2347
  year: 2004
  ident: ref_52
  article-title: Active NF-kappaB signalling is a prerequisite for influenza virus infection
  publication-title: J. Gen. Virol.
  doi: 10.1099/vir.0.79958-0
– volume: 60
  start-page: 1620
  year: 2017
  ident: ref_83
  article-title: The Essential Medicinal Chemistry of Curcumin
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.6b00975
– volume: 12
  start-page: 385
  year: 2015
  ident: ref_21
  article-title: Virucidal efficacy of treatment with photodynamically activated curcumin on murine norovirus bio-accumulated in oysters
  publication-title: Photodiagnosis Photodyn. Ther.
  doi: 10.1016/j.pdpdt.2015.06.005
– volume: 9
  start-page: 16086
  year: 2017
  ident: ref_18
  article-title: Synergistic antiviral effect of curcumin functionalized graphene oxide against respiratory syncytial virus infection
  publication-title: Nanoscale
  doi: 10.1039/C7NR06520E
– volume: 9
  start-page: 828
  year: 2019
  ident: ref_46
  article-title: Tetrahydrocurcumin-loaded vaginal nanomicrobicide for prophylaxis of HIV/AIDS: In silico study, formulation development, and in vitro evaluation
  publication-title: Drug Deliv. Transl. Res.
  doi: 10.1007/s13346-019-00633-2
– volume: 4
  start-page: 284
  year: 2014
  ident: ref_56
  article-title: Curcumin inhibits the replication of enterovirus 71 in vitro
  publication-title: Acta Pharm. Sin. B
  doi: 10.1016/j.apsb.2014.06.006
– volume: 95
  start-page: 307
  year: 2014
  ident: ref_61
  article-title: High virulence differences among phylogenetically distinct isolates of the fish rhabdovirus viral hemorrhagic septicaemia virus are not explained by variability of the surface glycoprotein G or the non-virion protein Nv
  publication-title: J. Gen. Virol.
  doi: 10.1099/vir.0.057448-0
– volume: 15
  start-page: 1902641
  year: 2019
  ident: ref_13
  article-title: High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots
  publication-title: Small
  doi: 10.1002/smll.201902641
– volume: 26
  start-page: 1015
  year: 2018
  ident: ref_24
  article-title: Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection
  publication-title: J. Food Drug Anal.
  doi: 10.1016/j.jfda.2017.12.006
– volume: 90
  start-page: 4454
  year: 2016
  ident: ref_63
  article-title: The Attenuation Phenotype of a Ribavirin-Resistant Porcine Reproductive and Respiratory Syndrome Virus Is Maintained during Sequential Passages in Pigs
  publication-title: J. Virol.
  doi: 10.1128/JVI.02836-15
– volume: 11
  start-page: 338
  year: 2013
  ident: ref_2
  article-title: Curcumin and its derivatives: Their application in neuropharmacology and neuroscience in the 21st century
  publication-title: Curr. Neuropharmacol.
  doi: 10.2174/1570159X11311040002
– volume: 12
  start-page: 3871
  year: 2004
  ident: ref_48
  article-title: Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents
  publication-title: Bioorg. Med. Chem.
  doi: 10.1016/j.bmc.2004.05.006
– ident: ref_69
  doi: 10.1016/j.phymed.2020.153317
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Snippet Curcumin, the primary curcuminoid compound found in turmeric spice, has shown broad activity as an antimicrobial agent, limiting the replication of many...
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SubjectTerms Animals
antiviral
antiviral agents
Antiviral Agents - pharmacology
bacteria
broad-spectrum
Curcuma - chemistry
curcumin
Curcumin - chemistry
Curcumin - pharmacology
DNA Viruses - classification
DNA Viruses - drug effects
fungi
Humans
Mice
phytochemical
Review
RNA Viruses - classification
RNA Viruses - drug effects
turmeric
Virus Diseases - drug therapy
viruses
Title Curcumin as an Antiviral Agent
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