Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

microRNAs are key regulators of the human transcriptome across a number of diverse biological processes, such as development, aging and cancer, where particular miRNAs have been identified as tumour suppressive and oncogenic. In this work, we elucidate, in a comprehensive manner, across 15 epithelia...

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Veröffentlicht in:	Nature communications Jg. 9; H. 1; S. 5228 - 13
Hauptverfasser:	Dhawan, Andrew, Scott, Jacob G., Harris, Adrian L., Buffa, Francesca M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 07.12.2018 Nature Publishing Group Nature Portfolio
Schlagworte:	38/91 45/23 45/61 631/114/2164 631/208/176/2016 631/208/212/2019 631/67/69 692/4028/67/69 Aging Biological activity Cadherins - genetics Cancer Cell Proliferation - genetics Copy number Cyclin-Dependent Kinases - genetics Down-Regulation Epithelial-Mesenchymal Transition - genetics Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene regulation Gene Regulatory Networks Genomes Humanities and Social Sciences Humans Membrane Proteins - genetics Methylation MicroRNAs MicroRNAs - genetics miRNA multidisciplinary Mutation Neoplasms - classification Neoplasms - genetics PTEN Phosphohydrolase - genetics PTEN protein Redundancy Ribonucleic acid RNA Science Science (multidisciplinary) Signal Transduction - genetics Suppressors Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumors
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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