Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits

Clinical laboratory tests play a pivotal role in medical decision making, but little is known about their genetic variability between populations. We report a genome-wide association study with 45 clinically relevant traits from the population of Qatar using a whole genome sequencing approach in a d...

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Veröffentlicht in:	Nature communications Jg. 12; H. 1; S. 1250 - 10
Hauptverfasser:	Thareja, Gaurav, Al-Sarraj, Yasser, Belkadi, Aziz, Almotawa, Maryam, Suhre, Karsten, Albagha, Omar M. E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 23.02.2021 Nature Publishing Group Nature Portfolio
Schlagworte:	45/23 45/43 45/61 45/71 45/91 631/208/205/2138 692/308/2056 Biological Specimen Banks Decision making Gene frequency Gene Frequency - genetics Gene sequencing Genetic Loci Genetic variability Genetics, Population Genome, Human Genome-wide association studies Genome-Wide Association Study Genomes Heritability Humanities and Social Sciences Humans Japan Laboratory tests Linkage disequilibrium Linkage Disequilibrium - genetics Loci multidisciplinary Multifactorial Inheritance - genetics Performance prediction Polygenic inheritance Population genetics Populations Precision medicine Principal Component Analysis Qatar Quantitative Trait, Heritable Science Science (multidisciplinary) Sequence Analysis, DNA Whole genome sequencing Japan Qatar
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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