Using developmental regression to reorganize the clinical importance of autistic atypicalities

Early regression (ER) is often reported in autistic children with a prototypical phenotype and has been proposed as a possible pathognomonic sign present in most autistic children. Despite the uncertainties attached to its definition and report, using ER to anchor the autism phenotype could help ide...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Translational psychiatry Jg. 12; H. 1; S. 498 - 6
Hauptverfasser: Gagnon, David, Zeribi, Abderrahim, Douard, Élise, Courchesne, Valérie, Huguet, Guillaume, Jacquemont, Sébastien, Loum, Mor Absa, Mottron, Laurent
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.12.2022
Nature Publishing Group
Schlagworte:
692/53/2421
692/699/476/1373
Autism Spectrum Disorder - diagnosis
Autistic children
Autistic Disorder - diagnosis
Behavioral Sciences
Biological Psychology
Cross-Sectional Studies
Genotype & phenotype
Humans
Medicine
Medicine & Public Health
Neurosciences
Pharmacotherapy
Psychiatry
Regression analysis
Retrospective Studies
Stereotyped Behavior
ISSN:2158-3188, 2158-3188
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Early regression (ER) is often reported in autistic children with a prototypical phenotype and has been proposed as a possible pathognomonic sign present in most autistic children. Despite the uncertainties attached to its definition and report, using ER to anchor the autism phenotype could help identify the signs that best contribute to an autism diagnosis. We extracted retrospective data from 1547 autistic children between the ages of 6 and 18 years from the Simons Simplex collection. Logistic regression identified the atypicalities associated with a history of ER. Stepwise variable selection using logistic regression analysis followed by a bootstrap procedure of 1000 iterations identified the cluster of atypicalities best associated with ER. Linear and logistic regressions measured the association between combinations of atypicalities within the identified cluster and adaptative behaviors, diagnostic areas of severity, and other categories. Seven atypicalities significantly increased the likelihood of having experienced ER (OR = 1.73–2.13). Four (“hand leading—ever”, “pronominal reversal—ever”, “never shakes head at age 4–5” and “stereotypic use of objects or interest in parts of objects—ever”), when grouped together, best characterized the phenotype of verbal autistic children with ER. This clustering of signs was associated with certain persistent language difficulties, higher summary scores on a diagnostic scale for autism, and greater odds of receiving an “autistic disorder” diagnosis instead of another pervasive developmental disorder (PDD) diagnosis. These results raise questions about using language as a clinical specifier, defining cross-sectional signs independent of their relationship with an early developmental trajectory, and relying on polythetic criteria or equivalent weighted autistic atypicalities.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-022-02263-8