Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis

The pathogenesis of SARS-CoV-2 remains to be completely understood, and detailed SARS-CoV-2 cellular cytopathic effects requires definition. We performed a comparative ultrastructural study of SARS-CoV-1 and SARS-CoV-2 infection in Vero E6 cells and in lungs from deceased COVID-19 patients. SARS-CoV...

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Vydáno v:	Cell death & disease Ročník 12; číslo 3; s. 263 - 12
Hlavní autoři:	Nardacci, Roberta, Colavita, Francesca, Castilletti, Concetta, Lapa, Daniele, Matusali, Giulia, Meschi, Silvia, Del Nonno, Franca, Colombo, Daniele, Capobianchi, Maria Rosaria, Zumla, Alimuddin, Ippolito, Giuseppe, Piacentini, Mauro, Falasca, Laura
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 12.03.2021 Springer Nature B.V Nature Publishing Group
Témata:	13 13/51 14 14/1 14/19 14/28 14/63 692/420/254 692/699/255/2514 Animals Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Chlorocebus aethiops Cholesterol Coronaviruses COVID-19 COVID-19 - metabolism COVID-19 - pathology Cytopathogenesis Cytopathogenic Effect, Viral Drug therapy Homeostasis Humans Immunology Life Sciences Lipid Droplets - ultrastructure Lipid Droplets - virology Lipid Metabolism Lipids Lung - metabolism Lung - ultrastructure Lung - virology Lungs Mitochondria Pathogenesis Pathogenicity Pneumocytes SARS-CoV-2 - metabolism SARS-CoV-2 - ultrastructure Severe Acute Respiratory Syndrome - metabolism Severe Acute Respiratory Syndrome - pathology Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus - metabolism Severe acute respiratory syndrome-related coronavirus - ultrastructure Vacuoles Vero Cells
ISSN:	2041-4889, 2041-4889
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Shrnutí:	The pathogenesis of SARS-CoV-2 remains to be completely understood, and detailed SARS-CoV-2 cellular cytopathic effects requires definition. We performed a comparative ultrastructural study of SARS-CoV-1 and SARS-CoV-2 infection in Vero E6 cells and in lungs from deceased COVID-19 patients. SARS-CoV-2 induces rapid death associated with profound ultrastructural changes in Vero cells. Type II pneumocytes in lung tissue showed prominent altered features with numerous vacuoles and swollen mitochondria with presence of abundant lipid droplets. The accumulation of lipids was the most striking finding we observed in SARS-CoV-2 infected cells, both in vitro and in the lungs of patients, suggesting that lipids can be involved in SARS-CoV-2 pathogenesis. Considering that in most cases, COVID-19 patients show alteration of blood cholesterol and lipoprotein homeostasis, our findings highlight a peculiar important topic that can suggest new approaches for pharmacological treatment to contrast the pathogenicity of SARS-CoV-2.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-4889 2041-4889
DOI:	10.1038/s41419-021-03527-9