Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer

High-grade serous ovarian carcinomas (HGSOCs) with BRCA1/2 mutations exhibit improved outcome and sensitivity to double-strand DNA break (DSB)-inducing agents (i.e., platinum and poly(ADP-ribose) polymerase inhibitors [PARPis]) due to an underlying defect in homologous recombination (HR). However, r...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 14; H. 3; S. 429 - 439
Hauptverfasser:	Choi, Young Eun, Meghani, Khyati, Brault, Marie-Eve, Leclerc, Lucas, He, Yizhou J., Day, Tovah A., Elias, Kevin M., Drapkin, Ronny, Weinstock, David M., Dao, Fanny, Shih, Karin K., Matulonis, Ursula, Levine, Douglas A., Konstantinopoulos, Panagiotis A., Chowdhury, Dipanjan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 26.01.2016 Elsevier
Schlagworte:	Animals Antigens, Nuclear - genetics Antigens, Nuclear - metabolism Antineoplastic Agents - pharmacology Base Sequence BRCA1 Protein - genetics BRCA1 Protein - metabolism Cell Line, Tumor Disease-Free Survival DNA End-Joining Repair - drug effects DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Homologous Recombination - drug effects Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Ku Autoantigen Mice MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Oligonucleotides, Antisense - metabolism Organoplatinum Compounds - pharmacology Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Poly(ADP-ribose) Polymerase Inhibitors - pharmacology RNA Interference Sequence Alignment Tumor Suppressor p53-Binding Protein 1
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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